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Effects of titanium dioxide nanoparticle exposure on the gut microbiota of pearl oyster (Pinctada fucata martensii)
In this study, the toxicological effects of TiO2 nanoparticles were investigated on the intestinal health of pearl oyster (Pinctada fucata martensii). The pearl oysters were subjected to a 14-day exposure to 5-mg/L TiO2 nanoparticle, followed by a 7-day recovery period. Subsequently, the intestinal tissues were analyzed using 16S rDNA high-throughput sequencing. The results from LEfSe analysis revealed that TiO2 nanoparticle increased the susceptibility of pearl oysters to potential pathogenic bacteria infections. Additionally, the TiO2 nanoparticles led to alterations in the abundance of microbial communities in the gut o...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Fengfeng Li Yujing Lin Chuangye Yang Yilong Yan Ruijuan Hao Robert Mkuye Yuewen Deng Source Type: research

Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research

Effects of titanium dioxide nanoparticle exposure on the gut microbiota of pearl oyster (Pinctada fucata martensii)
In this study, the toxicological effects of TiO2 nanoparticles were investigated on the intestinal health of pearl oyster (Pinctada fucata martensii). The pearl oysters were subjected to a 14-day exposure to 5-mg/L TiO2 nanoparticle, followed by a 7-day recovery period. Subsequently, the intestinal tissues were analyzed using 16S rDNA high-throughput sequencing. The results from LEfSe analysis revealed that TiO2 nanoparticle increased the susceptibility of pearl oysters to potential pathogenic bacteria infections. Additionally, the TiO2 nanoparticles led to alterations in the abundance of microbial communities in the gut o...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Fengfeng Li Yujing Lin Chuangye Yang Yilong Yan Ruijuan Hao Robert Mkuye Yuewen Deng Source Type: research

Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research

Effects of titanium dioxide nanoparticle exposure on the gut microbiota of pearl oyster (Pinctada fucata martensii)
In this study, the toxicological effects of TiO2 nanoparticles were investigated on the intestinal health of pearl oyster (Pinctada fucata martensii). The pearl oysters were subjected to a 14-day exposure to 5-mg/L TiO2 nanoparticle, followed by a 7-day recovery period. Subsequently, the intestinal tissues were analyzed using 16S rDNA high-throughput sequencing. The results from LEfSe analysis revealed that TiO2 nanoparticle increased the susceptibility of pearl oysters to potential pathogenic bacteria infections. Additionally, the TiO2 nanoparticles led to alterations in the abundance of microbial communities in the gut o...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Fengfeng Li Yujing Lin Chuangye Yang Yilong Yan Ruijuan Hao Robert Mkuye Yuewen Deng Source Type: research

Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research

Effects of titanium dioxide nanoparticle exposure on the gut microbiota of pearl oyster (Pinctada fucata martensii)
In this study, the toxicological effects of TiO2 nanoparticles were investigated on the intestinal health of pearl oyster (Pinctada fucata martensii). The pearl oysters were subjected to a 14-day exposure to 5-mg/L TiO2 nanoparticle, followed by a 7-day recovery period. Subsequently, the intestinal tissues were analyzed using 16S rDNA high-throughput sequencing. The results from LEfSe analysis revealed that TiO2 nanoparticle increased the susceptibility of pearl oysters to potential pathogenic bacteria infections. Additionally, the TiO2 nanoparticles led to alterations in the abundance of microbial communities in the gut o...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Fengfeng Li Yujing Lin Chuangye Yang Yilong Yan Ruijuan Hao Robert Mkuye Yuewen Deng Source Type: research

Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research

Effects of titanium dioxide nanoparticle exposure on the gut microbiota of pearl oyster (Pinctada fucata martensii)
In this study, the toxicological effects of TiO2 nanoparticles were investigated on the intestinal health of pearl oyster (Pinctada fucata martensii). The pearl oysters were subjected to a 14-day exposure to 5-mg/L TiO2 nanoparticle, followed by a 7-day recovery period. Subsequently, the intestinal tissues were analyzed using 16S rDNA high-throughput sequencing. The results from LEfSe analysis revealed that TiO2 nanoparticle increased the susceptibility of pearl oysters to potential pathogenic bacteria infections. Additionally, the TiO2 nanoparticles led to alterations in the abundance of microbial communities in the gut o...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Fengfeng Li Yujing Lin Chuangye Yang Yilong Yan Ruijuan Hao Robert Mkuye Yuewen Deng Source Type: research

Early statin exposure influences cardiac and skeletal development with implications for ion channel transcriptomes in zebrafish
In this study, we investigated the developmental effects of two widely used statins, atorvastatin (ATO) and pravastatin (PRA), on zebrafish offspring. For ATO, we administered doses classified as low (1 μM), medium (5 μM), and high (10 μM), while for PRA, the corresponding concentrations were set at low (18 μM), medium (180 μM), and high (270 μM). Our results showed significant reductions in birth and hatching rates, along with decreased body length in offspring at all ATO concentrations and medium to high PRA concentrations. A notable increase in malformation rates, especially in the spine and heart, was observed ac...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Ying Zhao Hou-Zhi Yang Huinan Li Shuang Liang Meng Wang Chun-Di Li Donghai Zhuo Feifei Fan Miao Guo Xinxin Lv Lingzhu Zhang Xu Chen Shan-Shan Li Xin Jin Source Type: research

Transcriptomic profile in carbendazim-induced developmental defects in zebrafish (Danio rerio) embryos/larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar 22:109907. doi: 10.1016/j.cbpc.2024.109907. Online ahead of print.ABSTRACTCarbendazim is a widely used fungicide to protect agricultural and horticultural crops against a wide array of fungal species. Published reports have shown that the wide usage of carbendazim resulted in reprotoxicity, carcinogenicity, immunotoxicity, and developmental toxicity in mammalian models. However, studies related to the developmental toxicity of carbendazim in aquatic organisms are not clear. To address this gap, an attempt was made by exposing zebrafish embryos to carbendazim (800 μg/L) an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - March 24, 2024 Category: Biochemistry Authors: Gopi Krishna Pitchika B Krishna Naik G V V Ramana R Nirupama T Sri Ranjani K Venkaiah M Hanuma Reddy S B Sainath Jangampalli Adi Pradeepkiran Source Type: research