Comparative biochemistry and physiology. Toxicology and pharmacology : CBP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Oxidative stress responses in two marine diatoms during sulfamethoxazole exposure and the toxicological evaluation using the IBR < sub > v2 < /sub > index
This study aimed to investigate the toxic effects of SMX on the growth, photosynthetic pigment content, and oxidative stress of two marine microalgae species: Skeletonema costatum and Phaeodactylum tricornutum. SMX demonstrated a significant inhibitory effect on microalgae proliferation, with 96-h median effective concentration (EC50) values of 0.93 mg/L and 4.65 mg/L for S. costatum and P. tricornutum, respectively. At low concentrations, SMX significantly increased the production of Chl a in both microalgae species. However, in the higher concentration SMX treatment group, Chl a content in P. tricornutum experienced a si...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 11, 2023 Category: Biochemistry Authors: Pengfei Feng Hongwu Cui Chenyu Wang Xingyu Li Weiyan Duan Source Type: research

Protective effects of melanoidins from black garlic on zearalenone-induced toxicity in zebrafish embryonic developmental model
In this study, the alleviative effects of black garlic MLDs on ZEN-induced toxicity and the potential mechanisms were studied using zebrafish embryonic developmental model. The results showed that MLDs restored the ZEN-induced adverse influences on zebrafish embryonic development, including delay in hatching time, morphological abnormality and the impairment of nervous development. Further studies showed that MLDs significantly inhibited the ZEN-induced production of reactive oxygen species (ROS) and enhanced the intrinsic antioxidant ability by increasing the activities of superoxide dismutase (SOD), glutathione peroxidas...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 11, 2023 Category: Biochemistry Authors: Guangchao Yang Qian Yang Trust Beta Qin Liu Zhenzhu Zhu Fei Shen Source Type: research

Influence of multi-walled carbon nanotubes on the toxicity of ZnO nanoparticles in the intestinal histopathology, apoptosis, and microbial community of common carp
In conclusion, the influence of MWCNTs on the toxicity of ZnONPs was related to the concentration and concentration ratio of the mixture.PMID:37951286 | DOI:10.1016/j.cbpc.2023.109790 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 11, 2023 Category: Biochemistry Authors: Xiaochan Gao Hongtao Ren Yong Huang Yimin Li Jiaqi Shen Source Type: research

Exploring the effects of eugenol, menthol, and lidocaine as anesthetics on zebrafish glucose homeostasis
This study, therefore, concludes that eugenol and menthol are safe and satisfactory anesthetics for use in zebrafish research involving glucose analyses, while lidocaine use can cause biases due to altered glucose levels and safety concerns. Researchers should, therefore, carefully consider anesthetic selection to ensure reliable results in zebrafish assessments.PMID:37935341 | DOI:10.1016/j.cbpc.2023.109784 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 7, 2023 Category: Biochemistry Authors: Gabriela Maressa Machado Baesso Amanda Vit ória Venâncio L ívia Costa Varela Barca Pepita Fernanda Peppi Caique Aparecido Faria Jo ão Pedro Cosmo Machado Luiz David Solis Murgas Álvaro José de Almeida Bicudo Eduardo Maur ício Mendes de Lima Andr é Source Type: research

The effects of valproic acid neurotoxicity on aggressive behavior in zebrafish autism model
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Nov 3:109783. doi: 10.1016/j.cbpc.2023.109783. Online ahead of print.ABSTRACTValproic acid (VPA) is an effective drug, which is preferred for the treatments of epilepsy and various kinds of seizures. Nonetheless, VPA has many side effects associated with autism spectrum disorder (ASD). Therefore, we conducted molecular and behavior tests in adult proactive zebrafish after VPA exposure to investigate gene transcription changes, social behavior, aggression, anxiety and locomotion. Our findings revealed that VPA exposure generates ASD-like phenotypes and behaviors: genes associat...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 5, 2023 Category: Biochemistry Authors: Xiaoxue Li Tangsong Feng Weiqun Lu Source Type: research

Differences on the level of hepatic transcriptome between two flatfish species in response to liver cancer and environmental pollution levels
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Nov 3;275:109781. doi: 10.1016/j.cbpc.2023.109781. Online ahead of print.ABSTRACTEnvironmental factors can cause cancer in both wild animals and humans. In ecological settings, genetic variation and natural selection can sometimes produce resilience to the negative impacts of environmental change. An increase in oncogenic substances in natural habitats has therefore, unintentionally, created opportunities for using polluted habitats to study cancer defence mechanisms. The Baltic and North Sea are among the most contaminated marine areas, with a long history of pollution. Two f...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - November 3, 2023 Category: Biochemistry Authors: Tuul Sepp Ciara Baines Randel Kreitsberg J örn Peter Scharsack Pedro Nogueira Thomas Lang J érôme Fort Elin Sild John T Clarke Arvo Tuvikene Richard Meitern Source Type: research

Neurobehavioral impairments from chromium exposure: Insights from a zebrafish model and drug validation
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Oct 25;275:109780. doi: 10.1016/j.cbpc.2023.109780. Online ahead of print.ABSTRACTWe have developed a zebrafish model to explore the alterations in neurobehaviors resulting from both acute and chronic exposure to chromium (Cr). Zebrafish exposed to half (HC group: 19.7 mg/L) and a quarter (LC group: 9.85 mg/L) of the LD50 concentration of Cr for a span of 2 weeks exhibited aberrant locomotion, heightened anxiety, cognitive impairment, and reduced aggression - hallmark traits reminiscent of an Alzheimer's Disease (AD)-like syndrome. Furthermore, zebrafish exposed to an environm...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - October 26, 2023 Category: Biochemistry Authors: Seenivasan Boopathi B Haridevamuthu Akash Gandhi S P Ramya Ranjan Nayak Gokul Sudhakaran Rajakrishnan Rajagopal Selvaraj Arokiyaraj Jesu Arockiaraj Source Type: research