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N-nitrosodimethylamine exposure to zebrafish embryos/larvae causes cardiac and spinal developmental toxicity
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Dec 27;277:109823. doi: 10.1016/j.cbpc.2023.109823. Online ahead of print.ABSTRACTN-nitrosodimethylamine (NDMA), one of the new nitrogen-containing disinfection by-products, is potentially cytotoxic, genotoxic, and carcinogenic. Its potential toxicological effects have attracted a wide range of attention, but the mechanism is still not sufficiently understood. To better understand the toxicological mechanisms of NDMA, zebrafish embryos were exposed to NDMA from 3 h post-fertilization (hpf) to 120hpf. Mortality and malformation were significantly increased, and hatching rate, h...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 29, 2023 Category: Biochemistry Authors: Xiaoyi Liu Jinge Song Xiaotao Yan Pingping Li Jinhua Zhang Bin Wang Jing Si Yong Chen Source Type: research

Combined inhibitory effects of microcystin-LR and microcystin-RR on growth and development in zebrafish larvae
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Dec 26:109824. doi: 10.1016/j.cbpc.2023.109824. Online ahead of print.ABSTRACTMicrocystins (MCs) are the most widespread, frequently found, and seriously toxic cyanobacterial toxins in aquatic environments. Microcystin-leucine-arginine (MCLR) and microcystin-arginine-arginine (MCRR) are the most studied MCs. Normally, their levels are low and they coexist in the environment; however, they may also interact with each other. The developmental toxicity of MCLR in the presence of MCRR in the early life stage of zebrafish (from 2 to 120 h post fertilization) was investigated for th...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 28, 2023 Category: Biochemistry Authors: Xiao-Chun Guo Shao-Yong Lu Sheng-Nan Zhang Ping Xie Guang-Yu Li Zu-Qin Shi Yi-Tong Zhou Yu-Meng Wang Source Type: research

Prometryn exposure disrupts the intestinal health of Eriocheir sinensis: Physiological responses and underlying mechanism
In conclusion, our study contributes to understanding the molecular mechanisms behind the intestinal stress caused by herbicides on aquatic crustaceans.PMID:38145793 | DOI:10.1016/j.cbpc.2023.109820 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 25, 2023 Category: Biochemistry Authors: Peng Huang Jiancao Gao Jinliang Du Zhijuan Nie Quanjie Li Yi Sun Gangchun Xu Liping Cao Source Type: research

Corrigendum to "D-pinitol ameliorated H < sub > 2 < /sub > O < sub > 2 < /sub > -induced oxidative damage in PC12 cells and prolonged the lifespan by IIS pathway in Caenorhabditis elegans" [Comp. Biochem. Physiol., Part C 274 (2023) 109755]
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Dec 22;276:109819. doi: 10.1016/j.cbpc.2023.109819. Online ahead of print.NO ABSTRACTPMID:38141288 | DOI:10.1016/j.cbpc.2023.109819 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 23, 2023 Category: Biochemistry Authors: Miaosi Zhang Zhe Xu Liangyong Shao Jilite Wang Zouyan He Yumei Jiang Ye Zhang Hao Wang Source Type: research

Assessment of developmental toxicity and the potential mode of action underlying single and binary exposure to estrogenic endocrine disrupting chemicals in zebrafish (Danio rerio)
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Dec 19:109821. doi: 10.1016/j.cbpc.2023.109821. Online ahead of print.ABSTRACTThe current study investigated the effect of single and binary exposure to distinct xenoestrogens, including diethylstilbestrol (DES) and zearalenone (ZEN), on zebrafish embryos subjected to continuous exposure for 4 days starting from 4 h post fertilization. Noteworthy impact on cumulative mortality, hatchability, spinal and tail curvature, pericardial edema, and reduction in blood circulation were observed in DES-treated embryos, with lower incidence and intensity shown for ZEN at the same nominal ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 21, 2023 Category: Biochemistry Authors: Rehab Youssef Salama Ahmed Rumi Tanoue Xing Chen Yusuke K Kawai Akira Kubota Source Type: research