Comparative biochemistry and physiology. Toxicology and pharmacology : CBP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Multi-biomarker approach to evaluate the toxicity of chlorpyrifos (active ingredient and a commercial formulation) on different stages of Biomphalaria straminea
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 12:109923. doi: 10.1016/j.cbpc.2024.109923. Online ahead of print.ABSTRACTBiomphalaria straminea is a freshwater gastropod native to South America and used in toxicological assessments. Our aim was to estimate 48 h-LC50 and sub-chronic effects after the exposure to low concentrations of chlorpyrifos as commercial formulation (CF) and active ingredient (AI) on B. straminea adult, embryos and juveniles. Concentrations between 1 and 5000 μg L-1 were chosen for acute exposures and 0.1 and 1 μg L-1 for the sub-chronic one. After 14 days biochemical parameters, viability and s...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: A Bianco Karina N Martini Claudia J Tejedor Mar ía G Paredes Mar ía Kristoff Gisela Source Type: research

Comparison of developmental toxicity of graphene oxide and graphdiyne to zebrafish larvae
In this study, we compared with developmental toxicity of GO and GDY to zebrafish larvae. It was shown that exposure of zebrafish embryos from 5 h post fertilization to GO and GDY for up to 5 days decreased hatching rate and induced morphological deformity. Behavioral tests indicated that GO and GDY treatment led to hyperactivity of larvae. However, blood flow velocity was not significantly affected by GO or GDY. RNA-sequencing data revealed that both types of NMs altered gene expression profiles as well as gene ontology terms and KEGG pathways related with metabolism. We further confirmed that the NMs altered the expressi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Wanyan Wu Weichao Zhao Chaobo Huang Yi Cao Source Type: research

Exposure to hull cleaning wastewater induces mortality through oxidative stress and cholinergic disturbance in the marine polychaete Perinereis aibuhitensis
In this study, we provide evidence on acute harmful effects of hull cleaning wastewater in marine polychaete Perinereis aibuhitensis by analyzing physiological and biochemical parameters such as survival, burrowing activity, and oxidative status. Raw wastewater samples were collected during ship hull cleaning processes in the field. Two wastewater samples for the exposure experiment were prepared in the laboratory: 1) mechanically filtered in the in-water cleaning system (MF) and 2) additionally filtered with a 0.45 μm filter in the laboratory (LF). These wastewater samples contained high concentrations of metals (zinc an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 14, 2024 Category: Biochemistry Authors: Somyeong Lee Jaehee Kim Jee-Hyun Jung Moonkoo Kim Hyun Park Jae-Sung Rhee Source Type: research

Estradiol-17 β and bisphenol A affect growth and mineralization in early life stages of seabass
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 10:109921. doi: 10.1016/j.cbpc.2024.109921. Online ahead of print.ABSTRACTNatural and synthetic estrogens are contaminants present in aquatic ecosystems. They can have significant consequences on the estrogen-sensitive functions of organisms, including skeletal development and growth of vertebrate larvae. Synthetic polyphenols represent a group of environmental xenoestrogens capable of binding the receptors for the natural hormone estradiol-17β (E2). To better understand how (xeno-)estrogens can affect the skeleton in fish species with high ecological and commercial inter...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 12, 2024 Category: Biochemistry Authors: Camille Martinand-Mari Melanie Debiais-Thibaud Eric Potier Eric Gasset Gilbert Dutto Nicolas Leurs St éphane Lallement Emilie Farcy Source Type: research

Toxic effects of aniline in liver, gills and kidney of freshwater fish Channa punctatus after acute exposure
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Apr 8:109916. doi: 10.1016/j.cbpc.2024.109916. Online ahead of print.ABSTRACTAniline (C6H5NH2) is one of the hazardous aromatic amine where an amino group (-NH2) is connected to phenyl ring (C6H5). Based on the evaluation of the 96-hour LC50 of aniline, two sublethal concentrations (4.19 mg/l and 8.39 mg/l) were selected for acute exposure tests in freshwater fish Channa punctatus. The liver, gills and kidney of fish being the principal sites of xenobiotic material accumulation, respiration, biotransformation, and excretion are the focus of the present study. Throughout the ex...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 10, 2024 Category: Biochemistry Authors: Geetika Sharma Pooja Chadha Source Type: research

Effects of microplastics on key reproductive and biochemical endpoints of the freshwater microcrustacean Daphnia magna
In conclusion, the herein tested MPs have shown the potential to induce deleterious effects on D. magna mainly observed in terms of the reproductive outcomes. Changes at the biochemical level seems transient and are not likely to occur in long term, environmentally exposed crustaceans.PMID:38583695 | DOI:10.1016/j.cbpc.2024.109917 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 7, 2024 Category: Biochemistry Authors: David Daniel Madalena Vieira Jo ão Pinto da Costa Ana Violeta Gir ão Bruno Nunes Source Type: research

Bifenox induces hepatotoxicity and vascular toxicity in zebrafish embryos via ROS production and alterations in signaling pathways
This study aimed to determine the negative effects of bifenox, and its effects on higher eukaryotes. We found that early stages of zebrafish embryo exposed to bifenox demonstrated increased mortality and physiological defects, based on the LC50 value. Bifenox severely inhibited blood vessel growth by reducing key elements of complex connectivity; fluorescently tagged transgenic lines (fli1a:EGFP) showed morphological changes. Additionally, transgenic lines that selectively identified hepatocytes (fabp10a:DsRed) showed reduced fluorescence, indicating that bifenox may inhibit liver development. To evaluate the level of oxid...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - April 7, 2024 Category: Biochemistry Authors: Hahyun Park Taeyeon Hong Garam An Junho Park Gwonhwa Song Whasun Lim Source Type: research