Comparative biochemistry and physiology. Toxicology and pharmacology : CBP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Alteration of haematological and biochemical biomarkers after sub-lethal chronic malathion (Elathion ®) intoxication in freshwater fish, Labeo rohita (Hamilton, 1822)
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109844. doi: 10.1016/j.cbpc.2024.109844. Epub 2024 Jan 18.ABSTRACTThe present investigation aimed to evaluate the long-term effects of malathion (Elathion®) at two sub-lethal concentrations (0.36 and 1.84 mgL-1) for 45 days after the determination of 96 h-LC50 value (18.35 mgL-1) in a commercially important aquaculture species, Labeo rohita by assaying multiple biomarker approaches. Total erythrocyte count (TEC), and haemoglobulin count (Hb) were found to be decreased while total leucocyte counts (TLC) were increased (p < 0.05) in malathion-intoxicated fish. Malath...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 20, 2024 Category: Biochemistry Authors: Basanta Kumar Das Kausalya Kumari Nayak Vikas Kumar Source Type: research

Toxicology of chemical biocides: Anticoagulant rodenticides - Beyond hemostasis disturbance
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109841. doi: 10.1016/j.cbpc.2024.109841. Epub 2024 Jan 17.ABSTRACTThe use of anticoagulant rodenticides (ARs) is one of the most commonly employed management methods for pest rodents. ARs compete with vitamin K (VK) required for the synthesis of blood clotting factors in the liver, resulting in inhibition of blood coagulation and often animal death due to hemorrhage. Besides rodents (target species), ARs may affect non-target animal species and humans. Out of hemostasis disturbance, the effects of ARs may be related to the inhibition of proteins that require VK for the...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 18, 2024 Category: Biochemistry Authors: Aleksandra Popov Aleksandrov Dina Tucovic Jelena Kulas Dusanka Popovic Dragan Kataranovski Milena Kataranovski Ivana Mirkov Source Type: research

JM-20 potently prevents the onset of caffeine-induced anxiogenic phenotypes in zebrafish (Danio rerio)
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109843. doi: 10.1016/j.cbpc.2024.109843. Epub 2024 Jan 17.ABSTRACTAnxiety is among the most prevalent mental disorders present in the general population. Benzodiazepines are the most commonly prescribed drugs for the treatment of anxiety. Using zebrafish as a model organism, we investigated the anxiolytic activity of JM-20, a novel hybrid molecule with a 1,5-benzodiazepine ring fused to a dihydropyridine moiety. Firstly, we carried out some assays to analyze the possible toxicity mediated by JM-20. For this, zebrafish were exposed to different JM-20 concentrations (0-5...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 18, 2024 Category: Biochemistry Authors: Matheus M ülling Dos Santos Sabrina Antunes Ferreira Gabriel Teixeira de Macedo Mariana Torri Claro Talise Ellwanger M üller Alessandro de Souza Prestes Jo ão Batista Teixeira da Rocha Yanier N úñez-Figueredo Nilda de Vargas Barbosa Source Type: research

The influence of rainfall events on the toxicity of urban wastewaters to freshwater mussels Elliptio complanata
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109842. doi: 10.1016/j.cbpc.2024.109842. Epub 2024 Jan 17.ABSTRACTThe cumulative impacts of rainfall frequency and intensity towards the ecotoxicity of urban pollution is gaining more and more attention in these times of climate change. The purpose of this study was to examine the ecotoxicological impacts of combined sewers overflows and municipal effluent discharge sites during 3 periods (years) of varying intensity precipitations to freshwater mussels Elliptio complanata. Mussels were placed in benthic cages for 3 months during the summer at 2 overflow discharge and ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 18, 2024 Category: Biochemistry Authors: C Andr é J Auclair F Gagn é Source Type: research

Assessing cardiovascular toxicity in zebrafish embryos exposed to copper nanoparticles
This study demonstrated that CuNPs can induce cardiovascular toxicity at environmentally relevant concentrations during fish embryonic development and highlight the potential ecotoxicity of CuNPs to aquatic animals.PMID:38220071 | DOI:10.1016/j.cbpc.2024.109838 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 14, 2024 Category: Biochemistry Authors: Bu-Yuan Hsiao Jiun-Lin Horng Ching-Hua Yu Wen-Ting Lin Yu-Han Wang Li-Yih Lin Source Type: research

Comparison of cardiotoxicity induced by alectinib, apatinib, lenvatinib and anlotinib in zebrafish embryos
In this study, zebrafish embryos at 6 h post fertilization (hpf) were exposed to the four drugs at concentrations of 0.05-0.2 mg/L until 72 hpf, and then the development of these embryos was quantified, including heart rate, body length, yolk sac area, pericardial area, distance between venous sinus and balloon arteriosus (SV-BA), separation of cardiac myocytes and endocardium, gene expression, vascular development and oxidative stress. At the same exposure concentrations, alectinib and apatinib had little effect on the cardiac development of zebrafish embryos, while lenvatinib and anlotinib could induce significant cardio...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: Jieping Liu Wanbo Li Sujie Sun Ling Huang Mengqi Wan Xue Li Li Zhang Dou Yang Fasheng Liu Xinjun Liao Huiqiang Lu Juhua Xiao Shouhua Zhang Zigang Cao Source Type: research

Methods: A bioinformatic protocol for rapid analysis of zebrafish embryo photo-motory responses (PMR) in neurotoxicity testing
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109833. doi: 10.1016/j.cbpc.2024.109833. Epub 2024 Jan 11.ABSTRACTChemobehavioural phenotyping presents unique opportunities for analyzing neurotoxicants and discovering behavior-modifying neuroceuticals in small aquatic model organisms such as zebrafish (Danio rerio). A recently popularized approach in this field involves the utilization of zebrafish embryos for a photo-motor response (PMR) bioassay. The PMR bioassay entails stimulating zebrafish embryos between 24 and 36 h post fertilization (hpf) with a high-intensity light stimulus, inducing a transient increase in...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: Jason Henry Yutao Bai Florian Kreuder David Mawdsley Jan Kaslin Donald Wlodkowic Source Type: research

Effect of diisobutyl adipate on the expression of biomarker genes that respond to endocrine disruption and on gonadal sexual differentiation in Japanese medaka (Oryzias latipes)
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109836. doi: 10.1016/j.cbpc.2024.109836. Epub 2024 Jan 11.ABSTRACTPhthalate and non-phthalate plasticizers are used in polymer materials, such as plastic and rubber. It has recently been found that diisobutyl adipate (DIBA), which is considered an environmentally safe non-phthalate plasticizer, potentially acts as a thyroid disruptor in fish. Here, we investigated the sexual hormone effects of DIBA based on the expression levels of genes that respond to endocrine disruption and sexual hormone activity in the livers and gonads, and on gonadal sexual differentiation in J...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: Yoshifumi Horie Yuto Chihaya Chee Kong Yap Juan Manuel R íos Babu Rajendran Ramaswamy Dorcas Uaciquete Source Type: research

2,4-D-based herbicide underdoses cause mortality, malformations, and nuclear abnormalities in Physalaemus cuvieri tadpoles
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109840. doi: 10.1016/j.cbpc.2024.109840. Epub 2024 Jan 12.ABSTRACTAmphibians are considered bioindicators of the environment due to their high sensitivity and involvement in terrestrial and aquatic ecosystems. In the last two decades, 2,4-D has been one of the most widely used herbicides in Brazil and around the world, as its use has been authorized for genetically modified crops and therefore has been detected in surface and groundwater. Against this background, the aim of this work was to investigate the effects of environmentally relevant concentrations of 2,4-D-bas...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: Gilcin éia Dos Santos Camila F átima Rutkoski Alexandre Folador Vrandrieli Jucieli Skovronski Caroline M üller Aline Pompermaier Paulo Afonso Hartmann Marilia Hartmann Source Type: research

Mechanisms of PVP-functionalized silver nanoparticle toxicity in fish: Intravascular exposure disrupts cardiac pacemaker function and inhibits Na < sup > + < /sup > /K < sup > + < /sup > -ATPase activity in heart, but not gill
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109837. doi: 10.1016/j.cbpc.2024.109837. Epub 2024 Jan 12.ABSTRACTPolyvinylpyrrolidone-functionalized silver nanoparticles (nAgPVP) are popular in consumer products for their colloidal stability and antimicrobial activity. Whole lake additions of nAgPVP cause long term, ecosystem-scale changes in fish populations but the mechanisms underlying this effect are unclear. We have previously shown that in fish, nAgPVP impairs cardiac contractility and Na+/K+-ATPase (NKA) activity in vitro, raising the possibility that heart dysfunction could underlie population-level exposur...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: K S Parker N El E C Buldo T J MacCormack Source Type: research

Establishing a safe anesthesia concentration window for Nile tilapia (Oreochromis niloticus) (Linnaeus 1758) by monitoring cardiac activity in eugenol immersion baths
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Jan 11;278:109839. doi: 10.1016/j.cbpc.2024.109839. Online ahead of print.ABSTRACTNile tilapia, Oreochromis niloticus, is the most cultivated fish species in the world, due to its low cost, high growth rate, environmental adaptability, and resistance to disease and stress. Anesthetics for fish become necessary in management because they minimize mortality during transport and maintenance of ponds, one of the most used anesthetics is clove oil, which has eugenol as the major substance, representing 90-95 % of clove oil. The present study evaluates the effect of eugenol on cardi...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 13, 2024 Category: Biochemistry Authors: Clarissa Araujo da Paz Brenda Maria Pereira Alho da Costa Maria Klara Otake Hamoy Murilo Farias Dos Santos Lucas Lima da Rocha Yris da Silva Deiga Anara de Sousa Barbosa Anthony Lucas Gurgel do Amaral Tays Mata C âmara Gabriela Brito Barbosa Daniella Bas Source Type: research

Molecular and functional characterization of flavin-containing monooxygenases (FMO1-6) in tree shrews
In this study, tree shrew FMO1-6 cDNAs were isolated and characterized by sequence analysis, tissue expression, and metabolic function. Compared with human FMOs, tree shrew FMOs showed sequence identities of 85-90 % and 81-89 %, respectively, for cDNA and amino acids. Phylogenetic analysis showed that each tree shrew and human FMO were closely clustered. The genomic and genetic structures of the FMO genes were conserved in tree shrews and humans. Among the five tissue types analyzed (lung, heart, kidney, small intestine, and liver), FMO3 and FMO1 mRNAs were most abundant in liver and kidney, respectively. Recombinant tree ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - January 12, 2024 Category: Biochemistry Authors: Yasuhiro Uno Miaki Makiguchi Genki Ushirozako Kyoko Tsukiyama-Kohara Makiko Shimizu Hiroshi Yamazaki Source Type: research

N-nitrosodimethylamine exposure to zebrafish embryos/larvae causes cardiac and spinal developmental toxicity
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Mar;277:109823. doi: 10.1016/j.cbpc.2023.109823. Epub 2023 Dec 27.ABSTRACTN-nitrosodimethylamine (NDMA), one of the new nitrogen-containing disinfection by-products, is potentially cytotoxic, genotoxic, and carcinogenic. Its potential toxicological effects have attracted a wide range of attention, but the mechanism is still not sufficiently understood. To better understand the toxicological mechanisms of NDMA, zebrafish embryos were exposed to NDMA from 3 h post-fertilization (hpf) to 120hpf. Mortality and malformation were significantly increased, and hatching rate, heart rat...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 29, 2023 Category: Biochemistry Authors: Xiaoyi Liu Jinge Song Xiaotao Yan Pingping Li Jinhua Zhang Bin Wang Jing Si Yong Chen Source Type: research

N-nitrosodimethylamine exposure to zebrafish embryos/larvae causes cardiac and spinal developmental toxicity
Comp Biochem Physiol C Toxicol Pharmacol. 2023 Dec 27;277:109823. doi: 10.1016/j.cbpc.2023.109823. Online ahead of print.ABSTRACTN-nitrosodimethylamine (NDMA), one of the new nitrogen-containing disinfection by-products, is potentially cytotoxic, genotoxic, and carcinogenic. Its potential toxicological effects have attracted a wide range of attention, but the mechanism is still not sufficiently understood. To better understand the toxicological mechanisms of NDMA, zebrafish embryos were exposed to NDMA from 3 h post-fertilization (hpf) to 120hpf. Mortality and malformation were significantly increased, and hatching rate, h...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - December 29, 2023 Category: Biochemistry Authors: Xiaoyi Liu Jinge Song Xiaotao Yan Pingping Li Jinhua Zhang Bin Wang Jing Si Yong Chen Source Type: research