Comparative biochemistry and physiology. Toxicology and pharmacology : CBP This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Graphene oxide quantum dots (GOQDs) induce behavioral disorders via the disturbance of kynurenine pathway in zebrafish larvae
In conclusion, our study establishes the involvement of the kynurenine pathway in GOQDs-induced thigmotaxis, which is independent of the transcriptional modulation of glutamate receptor families.PMID:38403007 | DOI:10.1016/j.cbpc.2024.109865 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 25, 2024 Category: Biochemistry Authors: Shun Deng Enming Zhang Yunyang Zhao Hao Guo Lan Luo Song Yi Bingxin Zheng Xiaoyuan Mu Kezhu Yuan Xuangen Deng Haibo Rong Yanbo Ma Wanping Bian Hai Shen Source Type: research

Effect of salinity on the toxicokinetics, oxidative stress, and metallothionein gene expression in Meretrix meretrix exposed to cadmium
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 20:109863. doi: 10.1016/j.cbpc.2024.109863. Online ahead of print.ABSTRACTTo understand the effect of salinity on the toxicokinetics, oxidative stress, and detoxification of cadmium-exposed Meretrix meretrix, M. meretrix were acclimatized to different salinities (8, 14, 20, 26, and 32 ppt) for 14 d, exposed to 10 μg/L Cd for 7 d, followed by a 28-day depuration period. The internal Cd concentration was determined, and the activities of antioxidant enzymes (superoxide dismutase (SOD), catalase (CAT), and glutathione-S-transferase (GST)), and the malondialdehyde (MDA) conte...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 22, 2024 Category: Biochemistry Authors: Ming Sun Yuanyuan Jing Tianwen Zhang Fanguang Hu Qun Chen Guangbin Liu Source Type: research

Zinc mitigates cadmium-induced sperm dysfunction through regulating Ca < sup > 2+ < /sup > and metallothionein expression in the freshwater crab Sinopotamon henanense
In this study, we aimed to explore the protective effects of Zn against the sperm dysfunction induced by Cd in the freshwater crab Sinopotamon henanense. The results demonstrated that Cd exposure not only impaired the sperm ultrastructure, but also caused sperm dysfunction by decreasing the AR induction rate, acrosome enzyme activity, and Ca2+ content in sperm while elevating the activity and transcription expression of key Ca2+ signaling pathway-related proteins Calmodulin (CAM) and Ca2+-ATPase. However, the administration of Zn was found to alleviate Cd-induced sperm morphological and functional disorders by increasing t...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 22, 2024 Category: Biochemistry Authors: Jing Liu Ermeng Wang Zhipeng Xi Jingwei Dong Chienmin Chen Peng Xu Lan Wang Source Type: research

The angiogenesis-modulating effects of coumarin-derivatives
In this study, we examined the angiogenic modulating activities of six previously synthesized coumarin derivatives (Compound #1-#6) in zebrafish embryos and further confirmed them in a chick model. According to the survival rate in a zebrafish model, Compound #1 (100 %), #2 (82.5-100 %), and #4 (100 %) showed much less toxicity than Compound #3 (19.2-100 %), #5 (0-100 %), and #6 (0-100 %). Using a green blood vessel fluorescent transgenic fish Tg(fli1:egfp) to record the angiogenesis-modulating effects of Compound #1, #2, and #4, we found that Compound #2 had the highest effects in interfering intersegmental vessel growth,...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 21, 2024 Category: Biochemistry Authors: Han-Ting Huang Ching-Yuan Huang Chih-Jou Lee Bo-Jie Sun Zong-Wei Jhang Chi-Chung Wen Yun-Hsin Wang Tao-Sheng Li Ching-Yuh Chern Yau-Hung Chen Source Type: research

Biochemical, molecular, and physiological assessments of crude oil dietary exposure in sub-adult red drum (Sciaenops ocellatus)
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 18:109864. doi: 10.1016/j.cbpc.2024.109864. Online ahead of print.ABSTRACTA 14-day exposure study in which sub-adult red drum (Sciaenops ocellatus) were fed a petroleum crude oil-treated pellet feed was conducted to assess the potential effects of ingesting an oil-contaminated food source. Though food consumption decreased, significant polycyclic aromatic hydrocarbons accumulated in the body and liver, which did not affect the body and liver's fatty acid composition. In the red drum given the crude oil-treated feed, a significant decrease in the RNA:DNA growth rate index w...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 20, 2024 Category: Biochemistry Authors: Tracy A Sherwood Rebecca Medvecky Christelle Miller Dana L Wetzel Source Type: research

Constitutive immunity is influenced by avian influenza virus-induced modification of gut microbiota in Eurasian teal (Anas crecca)
In conclusion, the present study provides initial evidence of the alteration of the gut microbiome in the Eurasian teal Anas crecca by AIV infection and demonstrates that the AIV-induced reduction in constitutive immunity is a consequence of the shift in microbiome composition rather than the virus infection itself or its induced stress.PMID:38373511 | DOI:10.1016/j.cbpc.2024.109867 (Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP)
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 19, 2024 Category: Biochemistry Authors: Basma Sheta Omnia Waheed Esraa Ayad Lotfy Habbak Ayman Hyder Source Type: research

Developmental iron exposure induces locomotor alterations in Drosophila: Exploring potential association with oxidative stress
This study aims to explore Fe toxicity during D. melanogaster development, assessing oxidative stress and investigating behaviors in flies that are related to neurological conditions in humans. To achieve this goal, flies were exposed to Fe during the developmental period, and biochemical and behavioral analyses were conducted. The results indicated that 20 mM Fe decreased fly hatching by 50 %. At 15 mM, Fe exposure increased lipid peroxidation, and GSH levels decreased starting from 5 mM of Fe. Superoxide Dismutase activity was enhanced at 15 mM, while Glutathione S-Transferase activity was inhibited from 5 mM. Although c...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 19, 2024 Category: Biochemistry Authors: Ana Beatriz Dos Santos Jaciana Souza Dos Anjos Giany Gabriely Pad ão Dos Santos Maria Vit ória Takemura Mariano Luana Paganotto Leandro Marcelo Farina Jeferson Luis Franco Karen Kich Gomes Thais Posser Source Type: research

Does the anesthetic tricaine methanesulfonate (MS-222) distort oxidative status parameters in tadpoles?
Comp Biochem Physiol C Toxicol Pharmacol. 2024 Feb 17:109859. doi: 10.1016/j.cbpc.2024.109859. Online ahead of print.ABSTRACTThe effect of anesthesia/euthanasia with ethyl 3-aminobenzoate methanesulfonate (MS-222) on the oxidative status of Hyla arborea tadpoles was examined to determine whether the use of the anesthetic can confound the experimental results of the oxidative stress-based investigation. The experiment was conducted on two groups of tadpoles reared at different temperatures to produce differences in antioxidant capacity between the groups. After development at different temperatures (20 °C and 25 °C), the ...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 19, 2024 Category: Biochemistry Authors: Branka R Gavrilovi ć Svetlana G Despotovi ć Tamara G Petrovi ć Tijana B Radovanovi ć Jelena P Gavri ć Marko Mir č Marko An đelković Tanja Vukov Nata ša Tomašević Kolarov Marko D Proki ć Source Type: research

The concentration of dissolved organic matter impacts the neurobehavior in female zebrafish exposed to cyclophosphamide
In this study, we investigated the behaviors, morphological alterations of retina, and related gene transcripts in zebrafish exposed to CP (0 and 50 μg/L) and Humic acid (HA, a main component of DOM) at concentrations of 0, 3, 10, and 30 mg-C/L for 30 days. The results showed that, relative to the zebrafish in CP treatment, HA at 30 mg-C/L increased the locomotion (12.1 % in the light and 7.2 % in the dark) and startle response (9.7 %), while inhibiting the anxiety (12.5 %) and cognition of female zebrafish (24.6 %). The levels of transcripts of neurotransmitter- (tph1b and ache), neuroinflammation-(il-6 and tnfα) and an...
Source: Comparative biochemistry and physiology. Toxicology and pharmacology : CBP - February 19, 2024 Category: Biochemistry Authors: Tianming Liu Heru Dong Jianxing Zhao Dongshen Shang Yindong Li Rong Xie Source Type: research