Neurobehavioral Disturbances During Acute and Early HIV Infection
Conclusions: These data suggest that individuals who have recently acquired HIV experienced higher-than-normal premorbid levels of neurobehavioral disturbance. Apathy and executive dysfunction are exacerbated during AEH, particularly in association with lower CD4 counts. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - March 1, 2016 Category: Neurology Tags: Original Studies Source Type: research
Redefining Recovery from Aphasia
No abstract available (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Book Reviews Source Type: research
On the Move: A Life
No abstract available (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Book Reviews Source Type: research
“My Mind Is Doing It All”: No “Brake” to Stop Speech Generation in Jargon Aphasia
Conclusions: This patient with jargon aphasia highlights that voluminous speech output can arise from disturbances of both language and executive functions. Our previous studies have identified three conceptual preparation mechanisms for speech: generation of novel thoughts, their sequencing, and selection. This study raises the possibility that a “brake” to stop message generation may be a fourth conceptual preparation mechanism behind the pressure of speech characteristic of jargon aphasia. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Hypothesis-Generating Reports Source Type: research
Identification of Daily Activity Impairments in the Diagnosis of Parkinson Disease Dementia
Conclusions: Although most patients with PD had difficulties in ADL, we identified specific cognitive ADL items that could help in differentiating patients with and without dementia. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Hypothesis-Generating Reports Source Type: research
Wernicke-Korsakoff Syndrome as a Consequence of Delusional Food Refusal: A Case Study
We describe a 35-year-old man who developed Wernicke-Korsakoff syndrome with a typical neurologic and neuropsychological presentation after somatic delusions led him to refuse to eat. Cases like his serve to heighten awareness of the interplay between psychiatric and neurologic conditions, their sometimes atypical pathogenesis, and the value to primary care providers of consulting with psychiatrists, neurologists, and neuropsychologists when managing patients with possible Wernicke-Korsakoff syndrome. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Case Report Source Type: research
Working Memory Integration Processes in Benign Childhood Epilepsy with Centrotemporal Spikes
Conclusions: Children with BECTS may have intact simple maintenance processes of working memory, but difficulty with high-level functions requiring attentional and executive resources. Our findings imply no specific memory dysfunction in BECTS, but suggest difficulties in integrating information within working memory, and possible frontal lobe disturbances. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Original Studies Source Type: research
Impact of Elevated Core Body Temperature on Attention Networks
Conclusions: Different attentional abilities had different sensitivities to thermal stress. Executive control of attention deteriorated linearly with a rise in Tcore within the normal physiologic range, but deteriorated nonlinearly with longer passive heat exposure. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Original Studies Source Type: research
Impairments in the Face-Processing Network in Developmental Prosopagnosia and Semantic Dementia
Conclusions: These two disorders of face processing represent clinically distinguishable disturbances along a right hemisphere face-processing network: DP, characterized by early configural agnosia for faces, and SD, characterized primarily by a multimodal person knowledge disorder. We discuss these preliminary findings in the context of the current literature on the face-processing network; recent studies suggest an additional right anterior temporal, unimodal face familiarity-memory deficit consistent with an “associative prosopagnosia.” (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Original Studies Source Type: research
Effects of Recent Concussion on Brain Bioenergetics: A Phosphorus-31 Magnetic Resonance Spectroscopy Study
Conclusions: Our results support the concept of increased energy demand in the prefrontal cortex of a concussed brain, and we found that while neurocognitive assessments appear normal, brain energetics may be abnormal. A longitudinal study could help establish brain NTP levels as a biomarker to aid in diagnosis and to assess recovery in concussed patients. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - December 1, 2015 Category: Neurology Tags: Original Studies Source Type: research
Functional Mapping of the Human Auditory Cortex: fMRI Investigation of a Patient with Auditory Agnosia from Trauma to the Inferior Colliculus
Conclusions: Auditory agnosia reflects dysfunction of the auditory ventral stream. The ventral and dorsal auditory streams are already segregated as early as the primary auditory cortex, with the ventral stream projecting from hR and the dorsal stream from hA1. M.L.’s leftward localization bias, preserved audiovisual integration, and phoneme perception are explained by preserved processing in her right auditory dorsal stream. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - September 1, 2015 Category: Neurology Tags: Case Reports Source Type: research
Neuropsychological Thoughts, Then and Now: A Tribute to Oscar Marin
This brief paper, inspired by an invitation to acknowledge and celebrate Oscar Marin’s great contributions to cognitive neurology and neuropsychology, reviews the case of a patient, T.P., who had significant deficits of naming, reading, and spelling. I first studied and reported this patient 35 years ago, in 1979, when I was significantly influenced by the work of Oscar Marin and his colleagues. I have recently had the unusual opportunity to do some brief reassessment of T.P.’s current (2015) cognitive abilities, and to reassess the interpretations that I had given to her pattern of impairment in the initial studies. I...
Source: Cognitive and Behavioral Neurology - September 1, 2015 Category: Neurology Tags: Case Reports Source Type: research
Alzheimer Lesions in the Autopsied Brains of People 30 to 50 Years of Age
Conclusions: Our study demonstrates that beta-amyloid deposits in the cerebral cortex appear as early as 40 years of age in APOE4 carriers, suggesting that these lesions may constitute a very early stage of Alzheimer disease. Future preventive and therapeutic measures for this disease may have to be stratified by risk factors like APOE genotype and may need to target people in their 40s or even earlier. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - September 1, 2015 Category: Neurology Tags: Original Study Source Type: research
Revisiting the Single-Case Approach to Studying Reading Disorders
Oscar Marin was a neurologist with a remarkably broad interest in the brain and its function. He was passionate about understanding how the brain processes language and about helping people with acquired language disorders through his science-based practice. Here we honor his memory by presenting a review and commentary charting the cycle of neuroscientific approaches to studying reading disorders over the past century. During this time, “best practices” have changed from individual case studies to group studies and mega-studies and back again to individual studies. We show how, across decades and almost unimaginable a...
Source: Cognitive and Behavioral Neurology - September 1, 2015 Category: Neurology Tags: Remembrances and Commentaries Source Type: research
A Visit with Oscar and Clara Marin
No abstract available (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - September 1, 2015 Category: Neurology Tags: Remembrances and Commentaries Source Type: research
