The Other Side of Impossible: Ordinary People Who Faced Daunting Medical Challenges and Refused to Give Up
No abstract available (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Book Reviews Source Type: research
A Man for All Seasons: Robert J. Joynt, MD, PhD
No abstract available (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Book Reviews Source Type: research
Clozapine Safety and Efficacy for Interictal Psychotic Disorder in Pharmacoresistant Epilepsy
We present a unique case in which we used clozapine successfully as a last resort treatment for chronic interictal psychosis in a 43-year-old woman with severe pharmacoresistant epilepsy and recurrent status epilepticus. Her psychotic symptoms improved markedly without an increase in the frequency of seizures despite gradual titration of the clozapine dose up to 300 mg daily. Her response demonstrates that, properly monitored, clozapine can be an effective treatment for psychosis even in patients with daily seizures. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Callosal Motor Impersistence: A Novel Disconnection Syndrome
In conclusion, motor impersistence of dominant limbs can result from isolated callosal injury that disconnects the left hemisphere from the right hemisphere’s frontal-subcortical networks. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Frontotemporal Dementia Presenting as Gambling Disorder: When a Psychiatric Condition Is the Clue to a Neurodegenerative Disease
We report a man who suddenly developed a gambling disorder when he was 55 years old. A year later he developed personality changes of agitation, euphoria, and disinhibition, along with binge eating and dysthymia. He did not improve on paroxetine 40 mg/day. Two years after the onset of his symptoms, he came to our clinic for evaluation. Neuropsychological testing showed deficits in cognitive control, planning, and attention. Brain magnetic resonance imaging and 18F-fluorodeoxyglucose positron emission tomography scans showed predominant frontal and temporal alterations, worse in the right hemisphere than the left. Cerebrosp...
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Relationship of Reaction Time to Perception of a Stimulus and Volitionally Delayed Response
Conclusions: On average, participants had marked delays when they tried to delay their responses slightly, but a subset of participants exhibited essentially no delay despite trying to delay. We suggest some potential mechanisms that future investigations might delineate. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Original Studies Source Type: research
Verbal and Figural Fluency in Temporal Lobe Epilepsy: Does Hippocampal Sclerosis Affect Performance?
Conclusions: Our study underlines differences in cognitive function between patients with mesial and lateral TLE, particularly in figural fluency. Although we cannot directly assess the role of the hippocampus in cognitive aspects of creative and divergent thinking related to figural fluency, the cognitive discrepancies between these two TLE groups could be ascribed to the mesial TLE hippocampal pathology shown in our study and addressed in the literature on hippocampal involvement in divergent thinking. Our findings could benefit cognitive rehabilitation programs tailored to the needs of patients with TLE. (Source: Cognit...
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Original Studies Source Type: research
Are Sex-Related Category-Specific Differences in Semantic Tasks Innate or Influenced by Social Roles? A Viewpoint
In semantic tasks, sex-related categorical differences, in the form of better processing of fruits and vegetables by women and of artifacts (human-made objects) and animals by men, have been reported both in healthy participants and in brain-damaged patients. Researchers’ interpretation of these sex-related categorical asymmetries has, however, been controversial, being connected with the more general (innatist versus experience-dependent) interpretations that had been given of the mechanisms subsuming the categorical organization of the brain. I begin this review with a brief reminder of the debate between supporters of...
Source: Cognitive and Behavioral Neurology - June 1, 2017 Category: Neurology Tags: Review Article Source Type: research
Ipsilateral Tremor-Like Grasp Reaction in a Patient With Ischemic Stroke
Reports of involuntary ipsilateral movements after a stroke are rare, and none have described a patient with both an instinctive grasp reaction and tremor-like movement ipsilateral to the acute stroke lesion. We here report such a patient. A 76-year-old right-handed woman with a past history of left thalamic hemorrhage developed left hemiparesis, an instinctive grasp reaction, and a peculiar involuntary movement of her right arm. This involuntary movement was stereotyped and sometimes rhythmical, with a groping or picking-like action. The lesion responsible for her motor deficits was a broad infarct in the right internal c...
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Shifting Spatial Neglect With Repeated Line Bisections: Possible Role of Lateralized Attentional Fatigue
Conclusions: The patient’s left-to-right shift with repeated trials suggests either fatigue from an attempted compensation for leftward inattention or habituation of a contralesional spatial attentional attraction, revealing contralesional left-sided neglect in both the left and right spaces. Future studies are needed to learn if other patients show similar or different deficits with repetition, and how best to treat them. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Genetic Alzheimer Disease and Sporadic Dementia With Lewy Bodies: A Comorbidity Presenting as Primary Progressive Aphasia
We report a 44-year-old woman, with a family history of early-onset dementia, presenting with primary progressive aphasia. This clinically variable syndrome has multiple underlying pathologies, and correlations between clinical manifestations and postmortem neuropathologic findings are controversial. Our patient suffered worsening language impairment with major word-finding difficulties but preserved comprehension. She also developed episodic memory impairment. Her condition progressed to dementia with behavioral changes. Magnetic resonance imaging showed early left perisylvian and bitemporal atrophy. The patient died shor...
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Case Reports Source Type: research
Relationship of Cognitive Function to Motor Symptoms and Mood Disorders in Patients With Isolated Dystonia
Conclusions: The nonmotor features of dystonia include subtle cognitive symptoms and high rates of mood disorders, both of which occur independent of motor symptom severity and level of disability. Thus, we would argue that isolated dystonia is a tripartite disorder, with motor, affective, and subtle cognitive features. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Original Studies Source Type: research
Predictors That a Diagnosis of Mild Cognitive Impairment Will Remain Stable 3 Years Later
Conclusions: Not all patients with MCI progress to dementia. Of the protective factors that we identified from demographic, functional, and cognitive data, the absence of apolipoprotein E4 alleles best predicted MCI stability. Our predictors may help clinicians better evaluate and treat patients, and may help researchers recruit more homogeneous samples for clinical trials. (Source: Cognitive and Behavioral Neurology)
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Original Studies Source Type: research
Transient Global Amnesia: Commentary on Trip Gabriel’s First-Person Account
This paper comments on a companion article, a first-person account of an episode of transient global amnesia written by New York Times reporter Trip Gabriel (Gabriel T. 2017. Cogn Behav Neurol. 30:1-4). Mr Gabriel describes having no memories of a cold, rainy day that he had spent on a sailboat competing in two races. The episode may have been triggered by his exposure to water. Afterward, the skipper recalled that Mr Gabriel had functioned fine on the boat, although after returning to shore he needed help finding his car. When he told his wife over the phone that he could not remember where he lived, she got him home and ...
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: Invited Commentary Source Type: research
The Day That Went Missing: A First-Person Account of Transient Global Amnesia
In this vivid first-person case history, political reporter Trip Gabriel describes experiencing a classic episode of transient global amnesia. He was near the average target age of 61. Although no cause has been established for the syndrome, as with many other patients his episode appears to have been triggered by contact with water: He was racing a sailboat. While remaining alert and handling complex sailing maneuvers, he suddenly developed amnesia that left him with no recollection of finishing two races, returning to shore, drinking a beer with his friends, needing help finding his car, and not knowing where he was or w...
Source: Cognitive and Behavioral Neurology - March 1, 2017 Category: Neurology Tags: First-Person Case History Source Type: research
