Characterizing dry mass and volume changes in human multiple myeloma cells upon treatment with proteotoxic and genotoxic drugs
AbstractMultiple myeloma (MM) is a cancer of terminally differentiated plasma cells. MM remains incurable, but overall survival of patients has progressively increased over the past two decades largely due to novel agents such as proteasome inhibitors (PI) and the immunomodulatory agents. While these therapies are highly effective, MM patients can be de novo resistant and acquired resistance with prolonged treatment is inevitable. There is growing interest in early, accurate identification of responsive versus non-responsive patients; however, limited sample availability and need for rapid assays are limiting factors. Here...
Source: Clinical and Experimental Medicine - July 8, 2023 Category: Research Source Type: research
Autoimmune liver disease and multiple sclerosis: state of the art and future perspectives
AbstractClinical observations suggest that the prevalence of autoimmune diseases is changing over time. Both autoimmune liver diseases and multiple sclerosis have shown a significant increase in the last decades. Although the coexistence of autoimmune diseases within individuals and families is a common phenomenon, the extent to which liver disease and multiple sclerosis co-occur is not clear. Case reports and few studies have reported the possible coexistence of multiple sclerosis with thyroid diseases, inflammatory bowel disease, psoriasis, and rheumatoid arthritis. It is unknown whether there is a definite association b...
Source: Clinical and Experimental Medicine - July 8, 2023 Category: Research Source Type: research
Prognostic value of primary tumor location in colorectal cancer: an updated meta-analysis
AbstractThe clinical, histological, and molecular differences between right-sided colon cancer (RCC) and left-sided colon cancer (RCC) have received considerable attention. Over the past decade, many articles have been published concerning the association between primary tumor location (PTL) of colorectal cancer and survival outcomes. Therefore, there is a growing need for an updated meta-analysis integrating the outcomes of recent studies to determine the prognostic role of right vs left-sidedness of PTL in patients with colorectal cancer. We conducted a comprehensive database review using PubMed, SCOPUS, and Cochrane lib...
Source: Clinical and Experimental Medicine - July 5, 2023 Category: Research Source Type: research
A novel angiogenesis-related scoring model predicts prognosis risk and treatment responsiveness in diffuse large B-cell lymphoma
In this study, we used univariate Cox regression to identify prognostic ARGs and found two distinct clusters of DLBCL patients in the GSE10846 dataset based on the expression of these prognostic ARGs. These two clusters had different prognoses and immune cell infiltration. Using LASSO regression analysis, we constructed a novel seven-ARG-based scoring model in GSE10846 dataset, and it was further validated in the GSE87371 dataset. The DLBCL patients were divided into high- and low-score groups based on the median risk score as a cut-off. The high-score group had a worse prognosis and showed higher expression of immune chec...
Source: Clinical and Experimental Medicine - July 4, 2023 Category: Research Source Type: research
Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis
ConclusionThe growth rate of publications regarding ADs and COVID-19 has risen sharply. Our research results can help researchers grasp the current status of ADs and COVID-19 research and find new research directions in the future. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - July 3, 2023 Category: Research Source Type: research
Association of serum cortisol and cortisone levels and risk of recurrence after endocrine treatment in breast cancer
In conclusion, breast cancer patients with low baseline cortisol levels were more likely to experience recurrence. During follow-up, cortisol and cortisone levels decreased in relaps e-free patients but increased in patients with recurrence. Thus, cortisol and cortisone may act as potential biomarkers indicating individual risk of recurrence. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - July 3, 2023 Category: Research Source Type: research
Knowledge mapping of COVID-19 and autoimmune diseases: a visual and bibliometric analysis
ConclusionThe growth rate of publications regarding ADs and COVID-19 has risen sharply. Our research results can help researchers grasp the current status of ADs and COVID-19 research and find new research directions in the future. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - July 3, 2023 Category: Research Source Type: research
Association of serum cortisol and cortisone levels and risk of recurrence after endocrine treatment in breast cancer
In conclusion, breast cancer patients with low baseline cortisol levels were more likely to experience recurrence. During follow-up, cortisol and cortisone levels decreased in relaps e-free patients but increased in patients with recurrence. Thus, cortisol and cortisone may act as potential biomarkers indicating individual risk of recurrence. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - July 3, 2023 Category: Research Source Type: research
Type 2 cytokines and scleroderma interstitial lung disease
AbstractInterstitial lung disease (ILD) is a life-threatening complication of systemic sclerosis (SSc). Type 2 (Th2) cytokines play a pivotal role in airway disease. Study aim was to evaluate serum level of Th2 interleukin (IL) and chemokine in SSc-ILD. Serum levels of IL-4, IL-5, IL-11, IL-13, IL-21, IL-31 and CXCL-13 were measured by Bio-Plex Multiplex Immunoassays in 60 SSc patients and 20 healthy controls (HC). Pulmonary function tests with diffusion lung capacity for carbon monoxide (DLco) and high resolution computed tomography (HRCT) were performed in SSc patients. ILD is defined as fibrotic changes (ground glass, r...
Source: Clinical and Experimental Medicine - July 1, 2023 Category: Research Source Type: research
Reactivation rates of hepatitis B or C or HIV in patients with psoriasis using biological therapies: a systematic review and meta-analysis
AbstractSome biological therapies for psoriasis can cause the reactivation of viral infections. Although recent studies suggest no increased rate of reactivation with biological therapies, some life-threatening cases have been reported. Therefore, this meta-analysis examined the rate of virus reactivation in patients with psoriasis with biological therapies and concurrent hepatitis B virus (HBV), hepatitis C virus (HCV), or human immunodeficiency virus (HIV) infection. PubMed, Embase, and the Cochrane Library were searched for available papers from inception to December 2021. The outcome was the number of patients with vir...
Source: Clinical and Experimental Medicine - July 1, 2023 Category: Research Source Type: research
Interleukin-33 and soluble suppression of tumorigenicity 2 in scleroderma cardiac involvement
AbstractInterleukin (IL)-33 is part of the IL-1 family of cytokines and soluble suppression of tumorigenicity 2 (sST2) is part of the family of IL-1 receptors. In systemic sclerosis (SSc), IL-33 and sST2 are involved in cardiac manifestations such as diastolic dysfunction (DD), autonomic dysfunction (AD) and right ventricular –pulmonary arterial coupling assessed by tricuspid annular plane systolic excursion (TAPSE)/systolic pulmonary artery pressure (sPAP). Serum levels of IL33 and sST2 were assessed in 50 SSc patients and 14 healthy controls (HC). Clinical assessment, echocardiography and heart rate variability (HRV) a...
Source: Clinical and Experimental Medicine - July 1, 2023 Category: Research Source Type: research
Clinical features and relapse risks factors of IgG4 related disease: a single-center retrospective study
ConclusionThe clinical features vary among different age groups and according to gender. The number of organs involved in IgG4-RD is related to the serum IgG4 concentration. Age (< 50 years old), low serum C4 concentration, a high number of involved organs, and lymph node involvement are risk factors for recurrence. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - July 1, 2023 Category: Research Source Type: research
Cytotoxic NK cells phenotype and activated lymphocytes are the main characteristics of patients with alcohol-associated liver disease
AbstractT cells, natural killer (NK) and NKT cells have opposing actions in the development of alcohol-associated liver fibrosis. We aimed to evaluate the phenotype of NK cells, NKT cells and activated T cells in patients with alcohol use disorder (AUD) according to the presence of advanced liver fibrosis (ALF). Totally, 79 patients (51-years, 71% males) were admitted to treatment of AUD. ALF was defined as FIB4-score > 2.67. Immunophenotyping of NK cells (CD3−CD56+CD16+, CD3−CD56+CD16−, CD3−CD56−CD16+), NKT-like (CD3+CD56+), and the activation status of CD4+, CD8+ and regulatory T cells (Tregs) were eva...
Source: Clinical and Experimental Medicine - July 1, 2023 Category: Research Source Type: research
