The kinetics of inhibitory immune checkpoints during and post-COVID-19: the knowns and unknowns
This article reviews the current knowledge about the kinetics and functioning of the IICPs during and post-COVID-19. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 11, 2023 Category: Research Source Type: research
LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis
AbstractIn spite of its high mortality rate and difficulty in finding a cure, scientific advancements have contributed to a reduction in cancer-related fatalities. Aberrant gene expression during carcinogenesis emphasizes the importance of targeting the signaling networks that control gene expression in cancer treatment. Long noncoding RNAs (lncRNAs), which are transcribed RNA molecules that play a role in gene expression regulation, are a recent innovative therapeutic approach for diagnosing and treating malignancies. MALAT1, a well-known lncRNA, functions in gene expression, RNA processing, and epigenetic control. High e...
Source: Clinical and Experimental Medicine - September 11, 2023 Category: Research Source Type: research
The kinetics of inhibitory immune checkpoints during and post-COVID-19: the knowns and unknowns
This article reviews the current knowledge about the kinetics and functioning of the IICPs during and post-COVID-19. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 11, 2023 Category: Research Source Type: research
LncRNA MALAT1 signaling pathway and clinical applications in overcome on cancers metastasis
AbstractIn spite of its high mortality rate and difficulty in finding a cure, scientific advancements have contributed to a reduction in cancer-related fatalities. Aberrant gene expression during carcinogenesis emphasizes the importance of targeting the signaling networks that control gene expression in cancer treatment. Long noncoding RNAs (lncRNAs), which are transcribed RNA molecules that play a role in gene expression regulation, are a recent innovative therapeutic approach for diagnosing and treating malignancies. MALAT1, a well-known lncRNA, functions in gene expression, RNA processing, and epigenetic control. High e...
Source: Clinical and Experimental Medicine - September 11, 2023 Category: Research Source Type: research
Combination of rituximab and short-term glucocorticoids in the treatment of anti-phospholipase A2 receptor antibody positive idiopathic membranous nephropathy
This study aimed to explore the clinical efficacy and safety of the combination of RTX and glucocorticoids (GC) in anti-phospholipase A2 receptor (anti-PLA2R) antibody positive IMN. Sixty-six patients were randomly divided into RTX/GC group (RTX infusion plus short-term oral GC) and RTX group (RTX infusion alone) in this prospective cohort study. Complete remission (CR) and partial remission (PR) were the primary outcomes. Adverse events were the secondary outcomes. The laboratory index including serum albumin, 24 h urinary protein, serum creatinine, estimated glomerular filtration rate, and anti-PLA2R antibody titer were ...
Source: Clinical and Experimental Medicine - September 9, 2023 Category: Research Source Type: research
Correction to: Multiparametric analysis of etoposide exposed mesenchymal stem cells and Fanconi anemia cells: implications in development of secondary myeloid malignancy
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 9, 2023 Category: Research Source Type: research
Combination of rituximab and short-term glucocorticoids in the treatment of anti-phospholipase A2 receptor antibody positive idiopathic membranous nephropathy
This study aimed to explore the clinical efficacy and safety of the combination of RTX and glucocorticoids (GC) in anti-phospholipase A2 receptor (anti-PLA2R) antibody positive IMN. Sixty-six patients were randomly divided into RTX/GC group (RTX infusion plus short-term oral GC) and RTX group (RTX infusion alone) in this prospective cohort study. Complete remission (CR) and partial remission (PR) were the primary outcomes. Adverse events were the secondary outcomes. The laboratory index including serum albumin, 24 h urinary protein, serum creatinine, estimated glomerular filtration rate, and anti-PLA2R antibody titer were ...
Source: Clinical and Experimental Medicine - September 9, 2023 Category: Research Source Type: research
Correction to: Multiparametric analysis of etoposide exposed mesenchymal stem cells and Fanconi anemia cells: implications in development of secondary myeloid malignancy
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 9, 2023 Category: Research Source Type: research
Different patterns of failure in two treatment regimens for primary central nervous system lymphoma, a retrospective analysis of 124 cases in Taiwan
AbstractTo explore prognostic factors and outcomes of primary central nervous system lymphoma (PCNSL) of diffuse large B-cell lymphoma (DLBCL) in Taiwan, 124 PCNSL-DLBCL patients (from 1995 to 2021) were retrospectively analyzed. Mainly, two treatment modalities including sandwich chemoradiotherapy and modified MATRix regimen were employed in these patients. Overall survival (OS) was determined by log-rank test and time-dependent Cox analysis. Median OS of all patients was 27.1 months. 47 (37.9%) patients who underwent sandwich chemoradiotherapy had a complete re mission (CR) rate of 87.2%, median OS of 53.9 months, a...
Source: Clinical and Experimental Medicine - September 7, 2023 Category: Research Source Type: research
Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives
ConclusionSex and family history of gout were independently and interactively associated with gout. Sex-wise, men had a higher risk of gout than women. Family history was associated with a higher risk of gout in both sexes, but men had a higher risk. Notably, men having both siblings and parents with gout had the highest risk of gout. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 5, 2023 Category: Research Source Type: research
Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia
AbstractPrimary Immune thrombocytopenia (ITP) is an autoimmune disease. Secondary ITP occurs in patients with underlying diseases such as common variable immunodeficiency (CVID). CVID is one of the most common symptomatic primary immunodeficiencies in adults, characterised by infectious and non-infectious symptoms. Amongst CVID patients, ITP is the most frequent autoimmune manifestation. In this single-centre study, we performed a clinical and immunological characterisation of 20 patients with CVID-related ITP and 20 ITP patients without CVID to compare severity and remission rates. We found that patients with CVID-related...
Source: Clinical and Experimental Medicine - September 5, 2023 Category: Research Source Type: research
Risk of gout in Taiwan Biobank participants pertaining to their sex and family history of gout among first-degree relatives
ConclusionSex and family history of gout were independently and interactively associated with gout. Sex-wise, men had a higher risk of gout than women. Family history was associated with a higher risk of gout in both sexes, but men had a higher risk. Notably, men having both siblings and parents with gout had the highest risk of gout. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - September 5, 2023 Category: Research Source Type: research
Clinical and immunological characterisation of patients with common variable immunodeficiency related immune thrombocytopenia
AbstractPrimary Immune thrombocytopenia (ITP) is an autoimmune disease. Secondary ITP occurs in patients with underlying diseases such as common variable immunodeficiency (CVID). CVID is one of the most common symptomatic primary immunodeficiencies in adults, characterised by infectious and non-infectious symptoms. Amongst CVID patients, ITP is the most frequent autoimmune manifestation. In this single-centre study, we performed a clinical and immunological characterisation of 20 patients with CVID-related ITP and 20 ITP patients without CVID to compare severity and remission rates. We found that patients with CVID-related...
Source: Clinical and Experimental Medicine - September 5, 2023 Category: Research Source Type: research
Angiopoietin4 (ANGPT4) expression and potential mechanisms in carcinogenesis: current achievements and perspectives
AbstractAngiopoietin4(ANGPT4) which plays a significant role in endothelial cell proliferation, survival, angiogenesis and expansion in tumors and other pathological states is a significant regulator of tumor angiogenesis. ANGPT4 expression is enhanced in many cancer cells. For example, the overexpression of ANGPT4 promotes the formation, development and progress of lung adenocarcinoma, glioblastoma and ovarian cancer. Related studies show that ANGPT4 encourages the proliferation, survival and invasion of tumor cells, while promoting the expansion of the tumor vascular system and affecting the tumor immune microenvironment...
Source: Clinical and Experimental Medicine - September 2, 2023 Category: Research Source Type: research
