Helios characterized circulating follicular helper T cells with enhanced functional phenotypes and was increased in patients with systemic lupus erythematosus
AbstractHelios was related to the immunosuppressive capacity and stability of regulatory T cells. However, the significance of Helios in follicular help T (TFH) and follicular regulatory T (TFR) cells is unclear. This research aimed to clarify the significance of Helios (IKZF2) in TFH and TFR cells and its clinical value in systemic lupus erythematosus (SLE).IKZF2 mRNA in different cell subsets was analyzed. Helios+ percentages in TFH and TFR cells were identified in the peripheral blood of 75 SLE patients and 62 HCs (healthy controls). PD-1 and ICOS expression were compared between Helios+ and Helios − cells. The capaci...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
Elevated serum IL-2 and Th17/Treg imbalance are associated with gout
This study compared the peripheral lymphocyte and CD4+T cell subsets, and cytokines in gout and healthy controls (HCs) to explore the contributions of T helper 17 (Th17) cells, T regulatory (Treg) cells and cytokines to the pathogenesis of gout. We enrolled 126 gout patients (53 early-onset gout with age of first presentation < 40 years, and 73 late-onset gout with age of first presentation ≥ 40 years) and 77 HCs. Percentage and absolute numbers of peripheral lymphocyte and CD4+T cell subpopulations in each group were detected by flow cytometry. The serum cytokine levels were determined by flow cytometric ...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
Efficacy of omalizumab in adult patients with allergic bronchopulmonary aspergillosis: a multicentre study in China
AbstractDespite conventional glucocorticoid and antifungal therapy, acute exacerbation and hospitalization occur frequently in patients with allergic bronchopulmonary aspergillosis (ABPA). Whether omalizumab is an effective and safe treatment for adult patients with ABPA complicating asthma. Patients with ABPA complicating asthma who were treated with omalizumab from October 2019 to May 2023 were collected from five tertiary hospitals and evaluated. The frequencies of acute exacerbation and hospitalization; the number of eosinophils; the total IgE levels; and the average monthly medical dosages after 3, 6, and 12 months ...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
Recent nanotheranostic approaches in cancer research
AbstractHumanity is suffering from cancer which has become a root cause of untimely deaths of individuals around the globe in the recent past. Nanotheranostics integrates therapeutics and diagnostics to monitor treatment response and enhance drug efficacy and safety. We hereby propose to discuss all recent cancer imaging and diagnostic tools, the mechanism of targeting tumor cells, and current nanotheranostic platforms available for cancer. This review discusses various nanotheranostic agents and novel molecular imaging tools like MRI, CT, PET, SPEC, and PAT used for cancer diagnostics. Emphasis is given to gold nanopartic...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
Assessment of bone turnover markers and DXA parameters to predict bone metastasis progression during zoledronate treatment: a single-center experience
AbstractBone metastases (BM) are a serious cancer complication, potentially causing substantial morbidity. Among the clinical issues related to BM, there is the lack of specific tools for early diagnosis and prognosis. We explored whether combining bone turnover markers (BTM) with dual-energy X-ray absorptiometry (DXA) assessment could identify early BM progression and risk of skeletal-related events (SREs) during zoledronate treatment. Before the initiation of zoledronate (T0) and after six months of treatment (T1), serum levels of five BTM were measured, and patients (N = 47) underwent DXA evaluation. Standard radiol...
Source: Clinical and Experimental Medicine - January 19, 2024 Category: Research Source Type: research
The demographic, laboratory and genetic factors associated with long Covid-19 syndrome: a case –control study
AbstractLong Covid-19 syndrome (LCS) manifests with a wide range of clinical symptoms, yet the factors associated with LCS remain poorly understood. The current study aimed to investigate the relationships that demographic characteristics, clinical history, laboratory indicators, and the frequency of HLA-I alleles have with the likelihood of developing LCS. We extracted the demographic characteristics and clinical histories from the medical records of 88 LCS cases (LCS+ group) and 96 individuals without LCS (LCS− group). Furthermore, we evaluated the clinical symptoms, serum levels of interleukin (IL)-6 and tumor necrosi...
Source: Clinical and Experimental Medicine - January 17, 2024 Category: Research Source Type: research
The Systemic Immune-Inflammation Index (SII) and coronary artery lesions in Kawasaki disease
AbstractCoronary artery lesions (CALs) are the most common complications of Kawasaki disease (KD) and play a crucial role in determining the prognosis of the disease. Consequently, the early identification of children with KD who are at risk of developing coronary artery damage is vitally important. We sought to investigate the relationship between the Systemic Immune-Inflammation Index (SII) and CALs in patients with KD and to assess its predictive value. We carried out a retrospective review and analysis of medical records for KD patients treated at the First Affiliated Hospital of Anhui Medical University between Januar...
Source: Clinical and Experimental Medicine - January 17, 2024 Category: Research Source Type: research
Longitudinal study of human polyomaviruses viruria in kidney transplant recipients
ConclusionsThe results suggested that JCPyV may be transmitted by allograft, and that its replication post KTx might prevent BKPyV reactivation. Future investigation regarding correlation between chronic exposure to immunosuppressive agents and HPyVs urinary replication are warranted. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - January 17, 2024 Category: Research Source Type: research
Tumor-derived cell-free DNA and circulating tumor cells: partners or rivals in metastasis formation?
AbstractThe origin of metastases is a topic that has sparked controversy. Despite recent advancements, metastatic disease continues to pose challenges. The first admitted model of how metastases develop revolves around cells breaking away from the primary tumor, known as circulating tumor cells (CTCs). These cells survive while circulating through the bloodstream and subsequently establish themselves in secondary organs, a process often referred to as the “metastatic cascade”. This intricate and dynamic process involves various steps, but all the mechanisms behind metastatic dissemination are not yet comprehensively el...
Source: Clinical and Experimental Medicine - January 17, 2024 Category: Research Source Type: research
Correction to: Reduced regulatory effects of bone marrow-derived mesenchymal stem cells on activated T lymphocytes and Th1/Th2 cytokine secretion in children with aplastic anemia
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - December 6, 2023 Category: Research Source Type: research
Correction to: Evaluation of Bruton tyrosine kinase inhibitors monotherapy and combination therapy in lymphocytic leukemia
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - December 2, 2023 Category: Research Source Type: research
Correction to: Diagnosis of interstitial lung disease (ILD) secondary to systemic sclerosis (SSc) and rheumatoid arthritis (RA) and identification of ‘progressive pulmonary fibrosis’ using chest CT: a narrative review
(Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - November 20, 2023 Category: Research Source Type: research
Real-life diagnostic and therapeutic approach to CLL: a 2022 update from an expert panel in Tuscany
AbstractA panel of chronic lymphocytic leukemia (CLL) experts from Tuscany propose a real-life diagnostic and therapeutic approach CLL that considers the role of genomic and somatic prognostic factors in risk stratification and treatment decisions. Safety and efficacy of new agents has been demonstrated now not only in clinical trials but also in many real-world series. The BTK inhibitors, ibrutinib and acalabrutinib, and BH3 mimetic venetoclax are now indicated as first-line therapy and chemoimmunotherapy can be spared to the majority of CLL patients, thus preventing unnecessary hematological and non-hematological toxicit...
Source: Clinical and Experimental Medicine - November 18, 2023 Category: Research Source Type: research
Clinical and imaging features of lymphomatosis cerebri: analysis of 8 cases and systematic review of the literature
AbstractLymphomatosis cerebri (LC) is a rare type of primary central nervous system lymphoma with diffuse, nonenhancing infiltrative lesions and is often misdiagnosed. Our study aimed to investigate the clinical characteristics and prognosis of LC through analyzing patients from the literature and our own center, so as to improve early diagnosis and treatment. PubMed, Web of Science and our hospital databases were reviewed, and information on demographic, clinical, pathological, cerebrospinal fluid (CSF), neuroimaging and treatment options was extracted. Univariate survival analysis was conducted by generating survival cur...
Source: Clinical and Experimental Medicine - November 18, 2023 Category: Research Source Type: research
Vaccine effectiveness of COVID-19 and rebound in the real world
AbstractWe intend to evaluate the relationship between the rates of global SARS-CoV-2 vaccination and the number of COVID-19 confirmed cases, as well as the mortality rate after the declaration of a pandemic. Of the data from 191 countries at the time of data retraction, we selected 111 countries that have SARS-CoV-2 vaccination reports. We stratified countries into high-income and non-high-income countries (HIC and non-HIC) based on World Bank income-group. We used a fixed-effects model (FEM) and performed a longitudinal analysis. The number of confirmed cases decreased as the vaccination rates increased in both non-HICs ...
Source: Clinical and Experimental Medicine - November 16, 2023 Category: Research Source Type: research
