Targeting redox regulation and autophagy systems in cancer stem cells
AbstractCancer is a dysregulated cellular level pathological condition that results in tumor formation followed by metastasis. In the heterogeneous tumor architecture, cancer stem cells (CSCs) are essential to push forward the progression of tumors due to their strong pro-tumor properties such as stemness, self-renewal, plasticity, metastasis, and being poorly responsive to radiotherapy and chemotherapeutic agents. Cancer stem cells have the ability to withstand various stress pressures by modulating transcriptional and translational mechanisms, and adaptable metabolic changes. Owing to CSCs heterogeneity and plasticity, t...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Untargeted metabolomics identifies potential serum biomarkers associated with Crohn ’s disease
AbstractCrohn ’s disease (CD) is well characterized by chronic inflammation of the gastrointestinal tract. The diagnose of CD relays on the comprehensive evaluation of patient symptoms, laboratory examination, radiology, and endoscopy. There is lack of biomarkers or simple test for CD detection. Serum samples f rom healthy subjects (n = 16) and CD patients (n = 16) were collected and prepared for untargeted metabolomics analysis using the ultra-high performance liquid chromatography-quadrupole time-of-flight mass spectrometry (UPLC-QTOF-MS) method. The alterations of serum metabolites and the potential biomarkers...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Adult-onset Still ’s disease and fever of unknown origin in India
AbstractDespite an essential differential diagnosis for fever of unknown origin (FUO) in young adults, adult-onset Still ’s disease (AOSD) is infrequently considered and remained underdiagnosed in low-middle-income countries. The present study analyzed the clinical, serological, radiological, and pathological characteristics of AOSD presented as FUO in India. A hospital-based retrospective study of patients aged > 13 years admitted with FUO and later diagnosed with AOSD in Postgraduate Institute of Medical Education and Research, Chandigarh (India), was conducted between January 2014 and December 2020. Petersdor...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Watson for oncology decision system for treatment consistency study in breast cancer
AbstractThe Watson for Oncology (WFO) decision system has been rolled out in many cancers. However, the consistency of treatment for breast cancer is still unclear in relatively economically disadvantaged areas. Patients with postoperative adjuvant stage (January 2017 to December 2017) and advanced-stage breast cancer (January 2014 to December 2018) in northwest of China were included in this study. Patient information was imported to make treatment decisions using Watson version 19.20 analysis and subsequently compared with clinician decisions and analyzed for influencing factors. A total of 263 patients with postoperativ...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Clinical significance of circulating tumor DNA in localized non-small cell lung cancer: a systematic review and meta-analysis
AbstractCirculating tumor DNA (ctDNA) detection holds promise for genetic analyses and quantitative assessment of tumor burden. A systematic review and meta-analysis were conducted to investigate the clinical relevance of ctDNA among patients with localized non-small cell lung cancer (NSCLC). PubMed, EMBASE, and the Cochrane Library were searched for eligible studies published from January 2001 to April 2022. After quality assessments and data extraction, diagnostic accuracy variables and prognostic data were calculated and analyzed by Meta-Disc 1.4, Review Manager 5.4.1, and STATA 17.0. Eight prospective studies and one r...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Prognostic and clinicopathological values of LINC00665 in cancers: a systematic review and China population-based meta-analysis
ConclusionLINC00665 expression was critically related to the cancer prognosis, which has important prognostic implications for clinical prediction. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
NCX1 disturbs calcium homeostasis and promotes RANKL-induced osteoclast differentiation by regulating JNK/c-Fos/NFATc1 signaling pathway in multiple myeloma
In conclusion, the Ca2+/NCX1-mediated signaling participates in the osteoclasts-myeloma cell interactions, which represents a promising target for future therapeutic intervention in MBD. (Source: Clinical and Experimental Medicine)
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Long non-coding RNA H19: a potential biomarker and therapeutic target in human malignant tumors
AbstractLong non-coding RNAs play important roles in cellular functions and disease development. H19, as a long non-coding RNA, is pervasively over-expressed in almost all kinds of human malignant tumors. Although many studies have reported that H19 is closely associated with tumor cell proliferation, apoptosis, invasion, metastasis, and chemoresistance, the role and mechanism of H19 in gene regulation and tumor development are largely unclear. In this review, we summarized the recent progress in the study of the major functions and mechanisms of H19 lncRNA in cancer development and progression. H19 possesses both oncogeni...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
The top 100 most cited articles in anaphylaxis: a bibliometric analysis
Abstract Bibliometric analysis is helpful to determine the most influential studies in a specific field. A large number of publications in anaphylaxis have been published. However, no bibliometric analysis of anaphylaxis was conducted based on our known. The aim of this study is to identify the top 100 most cited articles in anaphylaxis and analyze their bibliometric characteristics. We searched in the Web of Science core database on November 20, 2021. Articles were listed in descending order by their total citations. Hence the top 100 most cited articles in anaphylaxis were identified and analyzed. Bibliometric indicators...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Role of chemokines in the crosstalk between tumor and tumor-associated macrophages
AbstractTumor microenvironment (TME) consists of a dynamic network of non-tumoral stromal cells, including cancer-associated fibroblasts, endothelial cells, tumor-associated macrophages (TAMs), B and T cells. In the TME, TAMs support tumor initiation, progression, invasion and metastasis by promoting angiogenesis and immunosuppression of the tumor cells. There is close crosstalk between TAMs and tumor cells. Notably, chemokines are a significant messenger mediating the crosstalk between tumor cells and TAMs. TAMs can promote tumor progression via secretion of chemokines. Various chemokines secreted by tumors are involved i...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Association analysis of miRNA-146a and miRNA-499 polymorphisms with rheumatoid arthritis: a case –control and trio-family study
AbstractSingle nucleotide polymorphism is known to alter the expression and processing of miRNAs leading to a variety of diseases including rheumatoid arthritis (RA). However, disagreement is present up to date regarding the association of miRNA-146a and miRNA-499 polymorphisms with RA. The goal of this study was to assess the association of polymorphisms at miRNA-146a and miRNA-499 with the pathogenesis of RA in patients originating from Pakistan. Initially, eleven hundred subjects (1100) comprises of 550 RA patients and 550 healthy controls were investigated in the case –control analysis. Spectrophotometric measurement...
Source: Clinical and Experimental Medicine - August 30, 2023 Category: Research Source Type: research
Chronicling the 3-year evolution of the COVID-19 pandemic: analysis of disease management, characteristics of major variants, and impacts on pathogenicity
AbstractAnnounced on December 31, 2019, the novel coronavirus arising in Wuhan City, Hubei Province resulted in millions of cases and lives lost. Following intense tracking, coronavirus disease 2019 (COVID-19) was declared a pandemic by the World Health Organization (WHO) in 2020. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) was identified as the cause of COVID-19 and the continuous evolution of the virus has given rise to several variants. In this review, a comprehensive analysis of the response to the pandemic over the first three-year period is provided, focusing on disease management, development of vac...
Source: Clinical and Experimental Medicine - August 24, 2023 Category: Research Source Type: research
CXCL6: A potential therapeutic target for inflammation and cancer
AbstractChemokines were originally defined as cytokines that affect the movement of immune cells. In recent years, due to the increasing importance of immune cells in the tumor microenvironment (TME), the role of chemokines has changed from a single"chemotactic agent" to a key factor that can regulate TME and affect the tumor phenotype. CXCL6, also known as granulocyte chemoattractant protein-2 (GCP-2), can recruit neutrophils to complete non-specific immunity in the process of inflammation. Cancer-related genes and interleukin family can promote the abnormal secretion of CXCL6, which promotes tumor growth, metas...
Source: Clinical and Experimental Medicine - August 23, 2023 Category: Research Source Type: research
Immune landscape and oncobiota in HPV-Associated Colorectal Cancer: an explorative study
AbstractWorldwide more than 550,000 new patients suffering from malignant tumors are associated with human papillomaviruses (HPV) infection. However, only a small portion of patients infected progress to cancer, suggesting that other factors other than HPV may play a role. Some studies have investigated HPV infection in colorectal cancer (CRC) with discordant results; moreover, the role of HPV in CRC development is still unknown. We investigated HPV infection in 50 CRC from different regions, excluding the anal one, by immunohistochemistry (IHC), real-time PCR and RNA-seq. For each patient, we studied the tumor microenviro...
Source: Clinical and Experimental Medicine - August 23, 2023 Category: Research Source Type: research
