Circulation Research and 70 Years of Basic Science: Examining the Past and Looking Forward to the Future
Circ Res. 2024 Jan 5;134(1):6-8. doi: 10.1161/CIRCRESAHA.123.323177. Epub 2024 Jan 4.NO ABSTRACTPMID:38175906 | DOI:10.1161/CIRCRESAHA.123.323177 (Source: Circulation Research)
Source: Circulation Research - January 4, 2024 Category: Cardiology Authors: Jane E Freedman Source Type: research
Meet the First Authors
Circ Res. 2024 Jan 5;134(1):3-5. doi: 10.1161/RES.0000000000000651. Epub 2024 Jan 4.NO ABSTRACTPMID:38175907 | DOI:10.1161/RES.0000000000000651 (Source: Circulation Research)
Source: Circulation Research - January 4, 2024 Category: Cardiology Source Type: research
Editors and Editorial Board
Circ Res. 2024 Jan 5;134(1):1. doi: 10.1161/RES.0000000000000652. Epub 2024 Jan 4.NO ABSTRACTPMID:38175909 | DOI:10.1161/RES.0000000000000652 (Source: Circulation Research)
Source: Circulation Research - January 4, 2024 Category: Cardiology Source Type: research
Exploring the Connection Between Relaxed Myosin States and the Anrep Effect
Circ Res. 2024 Jan 5;134(1):117-134. doi: 10.1161/CIRCRESAHA.123.323173. Epub 2024 Jan 4.ABSTRACTThe Anrep effect is an adaptive response that increases left ventricular contractility following an acute rise in afterload. Although the mechanistic origin remains undefined, recent findings suggest a two-phase activation of resting myosin for contraction, involving strain-sensitive and posttranslational phases. We propose that this mobilization represents a transition among the relaxed states of myosin-specifically, from the super-relaxed (SRX) to the disordered-relaxed (DRX)-with DRX myosin ready to participate in force gene...
Source: Circulation Research - January 4, 2024 Category: Cardiology Authors: Vasco Sequeira Christoph Maack Gert-Hinrich Reil Jan-Christian Reil Source Type: research
Shedding Light on the Roles of Ceramide in Human Microvascular Function
Circ Res. 2024 Jan 5;134(1):97-99. doi: 10.1161/CIRCRESAHA.123.323868. Epub 2024 Jan 4.NO ABSTRACTPMID:38175911 | DOI:10.1161/CIRCRESAHA.123.323868 (Source: Circulation Research)
Source: Circulation Research - January 4, 2024 Category: Cardiology Authors: Charles D Searles Source Type: research
Legumain Regulates Regulatory T Cells in Hypertension
Circ Res. 2024 Jan 5;134(1):30-32. doi: 10.1161/CIRCRESAHA.123.324010. Epub 2024 Jan 4.NO ABSTRACTPMID:38175912 | DOI:10.1161/CIRCRESAHA.123.324010 (Source: Circulation Research)
Source: Circulation Research - January 4, 2024 Category: Cardiology Authors: Matthew R Alexander David G Harrison Source Type: research
SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis
CONCLUSIONS: Our findings demonstrate that reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine-tuning the transcriptional activity of HEY1. Specifically, SUMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA-binding capability in endothelial cells.PMID:38166414 | DOI:10.1161/CIRCRESAHA.123.323398 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: Ruizhe Ren Sha Ding Kefan Ma Yuanqing Jiang Yiran Wang Junbo Chen Yunyun Wang Yaohui Kou Xiao Fan Xiaolong Zhu Lingfeng Qin Cong Qiu Michael Simons Xiyang Wei Luyang Yu Source Type: research
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis
CONCLUSIONS: Myeloid CD147 plays a crucial role in the growth of plaques by promoting inflammation in a TRAF6-IKK-IRF5-dependent manner and inhibiting efferocytosis by suppressing GAS6 during proinflammatory conditions. Consequently, the use of anti-human CD147 antibodies presents a complementary therapeutic approach to the existing lipid-lowering strategies for treating atherosclerotic diseases.PMID:38166463 | DOI:10.1161/CIRCRESAHA.123.323223 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: Jian-Jun Lv Hao Wang Cong Zhang Tian-Jiao Zhang Hao-Lin Wei Ze-Kun Liu Yi-Hui Ma Zhi Yang Qian He Li-Juan Wang Li-Li Duan Zhi-Nan Chen Huijie Bian Source Type: research
ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban
CONCLUSIONS: These data point to ZBTB20 act as a fine-tuning modulator of PLN expression and SERCA2a activity, thereby offering new perspective on the regulation of basal contractility in the mammalian heart.PMID:38166470 | DOI:10.1161/CIRCRESAHA.123.323798 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: An-Jing Ren Chunchun Wei Ya-Jin Liu Mengna Liu Ping Wang Juan Fan Kai Wang Sha Zhang Zhenbang Qin Qiu-Xiao Ren Yanjun Zheng Yu-Xia Chen Zhifang Xie Ling Gao Yi Zhu Youyi Zhang Huang-Tian Yang Weiping J Zhang Source Type: research
SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis
CONCLUSIONS: Our findings demonstrate that reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine-tuning the transcriptional activity of HEY1. Specifically, SUMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA-binding capability in endothelial cells.PMID:38166414 | DOI:10.1161/CIRCRESAHA.123.323398 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: Ruizhe Ren Sha Ding Kefan Ma Yuanqing Jiang Yiran Wang Junbo Chen Yunyun Wang Yaohui Kou Xiao Fan Xiaolong Zhu Lingfeng Qin Cong Qiu Michael Simons Xiyang Wei Luyang Yu Source Type: research
CD147 Sparks Atherosclerosis by Driving M1 Phenotype and Impairing Efferocytosis
CONCLUSIONS: Myeloid CD147 plays a crucial role in the growth of plaques by promoting inflammation in a TRAF6-IKK-IRF5-dependent manner and inhibiting efferocytosis by suppressing GAS6 during proinflammatory conditions. Consequently, the use of anti-human CD147 antibodies presents a complementary therapeutic approach to the existing lipid-lowering strategies for treating atherosclerotic diseases.PMID:38166463 | DOI:10.1161/CIRCRESAHA.123.323223 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: Jian-Jun Lv Hao Wang Cong Zhang Tian-Jiao Zhang Hao-Lin Wei Ze-Kun Liu Yi-Hui Ma Zhi Yang Qian He Li-Juan Wang Li-Li Duan Zhi-Nan Chen Huijie Bian Source Type: research
ZBTB20 Regulates SERCA2a Activity and Myocardial Contractility Through Phospholamban
CONCLUSIONS: These data point to ZBTB20 act as a fine-tuning modulator of PLN expression and SERCA2a activity, thereby offering new perspective on the regulation of basal contractility in the mammalian heart.PMID:38166470 | DOI:10.1161/CIRCRESAHA.123.323798 (Source: Circulation Research)
Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: An-Jing Ren Chunchun Wei Ya-Jin Liu Mengna Liu Ping Wang Juan Fan Kai Wang Sha Zhang Zhenbang Qin Qiu-Xiao Ren Yanjun Zheng Yu-Xia Chen Zhifang Xie Ling Gao Yi Zhu Youyi Zhang Huang-Tian Yang Weiping J Zhang Source Type: research
Mitofusin-2 Regulates Platelet Mitochondria and Function
CONCLUSIONS: Mfn2 preserves mitochondrial phenotypes in megakaryocytes and platelets and influences platelet life span, function, and outcomes of stroke and lung injury.PMID:38156445 | DOI:10.1161/CIRCRESAHA.123.322914 (Source: Circulation Research)
Source: Circulation Research - December 29, 2023 Category: Cardiology Authors: Shancy Jacob Yasuhiro Kosaka Seema Bhatlekar Frederik Denorme Haley Benzon Alexandra Moody Victoria Moody Emilia Tugolukova Grayson Hull Nina Kishimoto Bhanu K Manne Li Guo Rhonda Souvenir Brayden J Seliger Alicia S Eustes Kelly Hoerger Neal D Tolley Amir Source Type: research
Mitofusin-2 Regulates Platelet Mitochondria and Function
CONCLUSIONS: Mfn2 preserves mitochondrial phenotypes in megakaryocytes and platelets and influences platelet life span, function, and outcomes of stroke and lung injury.PMID:38156445 | DOI:10.1161/CIRCRESAHA.123.322914 (Source: Circulation Research)
Source: Circulation Research - December 29, 2023 Category: Cardiology Authors: Shancy Jacob Yasuhiro Kosaka Seema Bhatlekar Frederik Denorme Haley Benzon Alexandra Moody Victoria Moody Emilia Tugolukova Grayson Hull Nina Kishimoto Bhanu K Manne Li Guo Rhonda Souvenir Brayden J Seliger Alicia S Eustes Kelly Hoerger Neal D Tolley Amir Source Type: research
Mitofusin-2 Regulates Platelet Mitochondria and Function
CONCLUSIONS: Mfn2 preserves mitochondrial phenotypes in megakaryocytes and platelets and influences platelet life span, function, and outcomes of stroke and lung injury.PMID:38156445 | DOI:10.1161/CIRCRESAHA.123.322914 (Source: Circulation Research)
Source: Circulation Research - December 29, 2023 Category: Cardiology Authors: Shancy Jacob Yasuhiro Kosaka Seema Bhatlekar Frederik Denorme Haley Benzon Alexandra Moody Victoria Moody Emilia Tugolukova Grayson Hull Nina Kishimoto Bhanu K Manne Li Guo Rhonda Souvenir Brayden J Seliger Alicia S Eustes Kelly Hoerger Neal D Tolley Amir Source Type: research
