Circadian Biology and the Neurovascular Unit
Circ Res. 2024 Mar 15;134(6):748-769. doi: 10.1161/CIRCRESAHA.124.323514. Epub 2024 Mar 14.ABSTRACTMammalian physiology and cellular function are subject to significant oscillations over the course of every 24-hour day. It is likely that these daily rhythms will affect function as well as mechanisms of disease in the central nervous system. In this review, we attempt to survey and synthesize emerging studies that investigate how circadian biology may influence the neurovascular unit. We examine how circadian clocks may operate in neural, glial, and vascular compartments, review how circadian mechanisms regulate cell-cell s...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Wenlu Li Steffen Tiedt Jennifer H Lawrence Mary E Harrington Erik S Musiek Eng H Lo Source Type: research
Circadian Rhythms of the Blood-Brain Barrier and Drug Delivery
Circ Res. 2024 Mar 15;134(6):727-747. doi: 10.1161/CIRCRESAHA.123.323521. Epub 2024 Mar 14.ABSTRACTThe blood-brain barrier (BBB) is a critical interface separating the central nervous system from the peripheral circulation, ensuring brain homeostasis and function. Recent research has unveiled a profound connection between the BBB and circadian rhythms, the endogenous oscillations synchronizing biological processes with the 24-hour light-dark cycle. This review explores the significance of circadian rhythms in the context of BBB functions, with an emphasis on substrate passage through the BBB. Our discussion includes efflux...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Mari Kim Richard F Keep Shirley L Zhang Source Type: research
Circadian Regulation of Cardiac Arrhythmias and Electrophysiology
Circ Res. 2024 Mar 15;134(6):659-674. doi: 10.1161/CIRCRESAHA.123.323513. Epub 2024 Mar 14.ABSTRACTCircadian rhythms in physiology and behavior are ≈24-hour biological cycles regulated by internal biological clocks (ie, circadian clocks) that optimize organismal homeostasis in response to predictable environmental changes. These clocks are present in virtually all cells in the body, including cardiomyocytes. Many decades ago, clinicians and researchers became interested in studying daily patterns of triggers for sudden cardiac death, the incidence of sudden cardiac death, and cardiac arrhythmias. This review highlights h...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Brian P Delisle Abhilash Prabhat Don E Burgess Makoto Ono Karyn A Esser Elizabeth A Schroder Source Type: research
Circadian Rhythms in Cardiovascular Metabolism
Circ Res. 2024 Mar 15;134(6):635-658. doi: 10.1161/CIRCRESAHA.123.323520. Epub 2024 Mar 14.ABSTRACTEnergetic demand and nutrient supply fluctuate as a function of time-of-day, in alignment with sleep-wake and fasting-feeding cycles. These daily rhythms are mirrored by 24-hour oscillations in numerous cardiovascular functional parameters, including blood pressure, heart rate, and myocardial contractility. It is, therefore, not surprising that metabolic processes also fluctuate over the course of the day, to ensure temporal needs for ATP, building blocks, and metabolism-based signaling molecules are met. What has become incr...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Hind Lal Suresh Kumar Verma Yajing Wang Min Xie Martin E Young Source Type: research
Circadian Mechanisms in Cardiovascular and Cerebrovascular Disease
Circ Res. 2024 Mar 15;134(6):615-617. doi: 10.1161/CIRCRESAHA.124.324462. Epub 2024 Mar 14.NO ABSTRACTPMID:38484030 | DOI:10.1161/CIRCRESAHA.124.324462 (Source: Circulation Research)
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Eng H Lo Frank M Faraci Source Type: research
Stroke in the Time of Circadian Medicine
Circ Res. 2024 Mar 15;134(6):770-790. doi: 10.1161/CIRCRESAHA.124.323508. Epub 2024 Mar 14.ABSTRACTTime-of-day significantly influences the severity and incidence of stroke. Evidence has emerged not only for circadian governance over stroke risk factors, but also for important determinants of clinical outcome. In this review, we provide a comprehensive overview of the interplay between chronobiology and cerebrovascular disease. We discuss circadian regulation of pathophysiological mechanisms underlying stroke onset or tolerance as well as in vascular dementia. This includes cell death mechanisms, metabolism, mitochondrial ...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Philipp Mergenthaler Joyce S Balami Ain A Neuhaus Amin Mottahedin Gregory W Albers Peter M Rothwell Jeffrey L Saver Martin E Young Alastair M Buchan Source Type: research
Circadian Effects on Vascular Immunopathologies
Circ Res. 2024 Mar 15;134(6):791-809. doi: 10.1161/CIRCRESAHA.123.323619. Epub 2024 Mar 14.ABSTRACTCircadian rhythms exert a profound impact on most aspects of mammalian physiology, including the immune and cardiovascular systems. Leukocytes engage in time-of-day-dependent interactions with the vasculature, facilitating the emigration to and the immune surveillance of tissues. This review provides an overview of circadian control of immune-vascular interactions in both the steady state and cardiovascular diseases such as atherosclerosis and infarction. Circadian rhythms impact both the immune and vascular facets of these i...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Qun Zeng Valeria Maria Oliva Mar ía Ángeles Moro Christoph Scheiermann Source Type: research
Circadian Clock and Hypoxia
Circ Res. 2024 Mar 15;134(6):618-634. doi: 10.1161/CIRCRESAHA.124.323518. Epub 2024 Mar 14.ABSTRACTThe timing of life on Earth is remarkable: between individuals of the same species, a highly similar temporal pattern is observed, with shared periods of activity and inactivity each day. At the individual level, this means that over the course of a single day, a person alternates between two states. They are either upright, active, and communicative or they lie down in a state of (un)consciousness called sleep where even the characteristic of neuronal signals in the brain shows distinctive properties. The circadian clock gov...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Francesca Sartor Borja Ferrero-Bordera Jeffrey Haspel Markus Sperandio Paul M Holloway Martha Merrow Source Type: research
Hypertension: Causes and Consequences of Circadian Rhythms in Blood Pressure
Circ Res. 2024 Mar 15;134(6):810-832. doi: 10.1161/CIRCRESAHA.124.323515. Epub 2024 Mar 14.ABSTRACTHypertension is extremely common, affecting approximately 1 in every 2 adults globally. Chronic hypertension is the leading modifiable risk factor for cardiovascular disease and premature mortality worldwide. Despite considerable efforts to define mechanisms that underlie hypertension, a potentially major component of the disease, the role of circadian biology has been relatively overlooked in both preclinical models and humans. Although the presence of daily and circadian patterns has been observed from the level of the geno...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Frank M Faraci Frank A J L Scheer Source Type: research
Circadian Mechanisms in Brain Fluid Biology
Circ Res. 2024 Mar 15;134(6):711-726. doi: 10.1161/CIRCRESAHA.123.323516. Epub 2024 Mar 14.ABSTRACTThe brain is a complex organ, fundamentally changing across the day to perform basic functions like sleep, thought, and regulating whole-body physiology. This requires a complex symphony of nutrients, hormones, ions, neurotransmitters and more to be properly distributed across the brain to maintain homeostasis throughout 24 hours. These solutes are distributed both by the blood and by cerebrospinal fluid. Cerebrospinal fluid contents are distinct from the general circulation because of regulation at brain barriers including t...
Source: Circulation Research - March 14, 2024 Category: Cardiology Authors: Velia S Vizcarra Ryann M Fame Lauren M Hablitz Source Type: research
Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function
CONCLUSIONS: Thrombocytopenia immune programs monocytes in a manner that may lead to immune dysfunction in the context of sepsis. This is the first demonstration that sterile, endogenous cell interactions between resting platelets and monocytes regulate monocyte metabolism and pathogen responses, demonstrating platelets to be immune rheostats in both health and disease.REGISTRATION: URL: https://www.biorxiv.org/content/10.1101/2023.05.10.540214v1.full; Unique identifier: XXX.PMID:38456277 | DOI:10.1161/CIRCRESAHA.123.323662 (Source: Circulation Research)
Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Chen Li Sara K Ture Benjamin Nieves-Lopez Sara K Blick-Nitko Preeti Maurya Alison C Livada Tyler J Stahl Minsoo Kim Anthony P Pietropaoli Craig N Morrell Source Type: research
Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis
CONCLUSIONS: These data demonstrated that hemodynamic stress induced a protective rewiring of sphingolipid metabolism, favoring S1P over ceramide. NOGO-B deletion sustained the rewiring of sphingolipid metabolism toward S1P protecting EC from activation under hemodynamic stress and refraining coronary atherosclerosis. These findings also set forth the foundation for sphingolipid-based therapeutics to limit atheroprogression.PMID:38456287 | DOI:10.1161/CIRCRESAHA.123.323826 (Source: Circulation Research)
Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Onorina Laura Manzo Jasmine Nour Linda Sasset Alice Marino Luisa Rubinelli Sailesh Palikhe Martina Smimmo Yang Hu Maria Rosaria Bucci Alain Borczuk Olivier Elemento Julie K Freed Giuseppe Danilo Norata Annarita Di Lorenzo Source Type: research
CNP Ameliorates Macrophage Inflammatory Response and Atherosclerosis
CONCLUSIONS: Our study reveals that CNP enhanced plaque stability and alleviated macrophage inflammatory responses by promoting HIF-1α degradation, suggesting a novel atheroprotective role of CNP. Enhancing CNP bioactivity may offer a novel pharmacological strategy for treating related diseases.PMID:38456298 | DOI:10.1161/CIRCRESAHA.123.324086 (Source: Circulation Research)
Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Qiankun Bao Bangying Zhang Lu Zhou Qian Yang Xiaofeng Mu Xing Liu Shiying Zhang Meng Yuan Yue Zhang Jingjin Che Wen Wei Tong Liu Guangping Li Jinlong He Source Type: research
Thrombocytopenia Independently Leads to Changes in Monocyte Immune Function
CONCLUSIONS: Thrombocytopenia immune programs monocytes in a manner that may lead to immune dysfunction in the context of sepsis. This is the first demonstration that sterile, endogenous cell interactions between resting platelets and monocytes regulate monocyte metabolism and pathogen responses, demonstrating platelets to be immune rheostats in both health and disease.REGISTRATION: URL: https://www.biorxiv.org/content/10.1101/2023.05.10.540214v1.full; Unique identifier: XXX.PMID:38456277 | DOI:10.1161/CIRCRESAHA.123.323662 (Source: Circulation Research)
Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Chen Li Sara K Ture Benjamin Nieves-Lopez Sara K Blick-Nitko Preeti Maurya Alison C Livada Tyler J Stahl Minsoo Kim Anthony P Pietropaoli Craig N Morrell Source Type: research
Rewiring Endothelial Sphingolipid Metabolism to Favor S1P Over Ceramide Protects From Coronary Atherosclerosis
CONCLUSIONS: These data demonstrated that hemodynamic stress induced a protective rewiring of sphingolipid metabolism, favoring S1P over ceramide. NOGO-B deletion sustained the rewiring of sphingolipid metabolism toward S1P protecting EC from activation under hemodynamic stress and refraining coronary atherosclerosis. These findings also set forth the foundation for sphingolipid-based therapeutics to limit atheroprogression.PMID:38456287 | DOI:10.1161/CIRCRESAHA.123.323826 (Source: Circulation Research)
Source: Circulation Research - March 8, 2024 Category: Cardiology Authors: Onorina Laura Manzo Jasmine Nour Linda Sasset Alice Marino Luisa Rubinelli Sailesh Palikhe Martina Smimmo Yang Hu Maria Rosaria Bucci Alain Borczuk Olivier Elemento Julie K Freed Giuseppe Danilo Norata Annarita Di Lorenzo Source Type: research
