Application of New Lineage Tracing Techniques in Cardiovascular Development and Physiology
Circ Res. 2024 Feb 16;134(4):445-458. doi: 10.1161/CIRCRESAHA.123.323179. Epub 2024 Feb 15.ABSTRACTCardiovascular disease has been the leading cause of mortality and morbidity worldwide in the past 3 decades. Multiple cell lineages undergo dynamic alternations in gene expression, cell state determination, and cell fate conversion to contribute, adapt, and even modulate the pathophysiological processes during disease progression. There is an urgent need to understand the intricate cellular and molecular underpinnings of cardiovascular cell development in homeostasis and pathogenesis. Recent strides in lineage tracing method...
Source: Circulation Research - February 15, 2024 Category: Cardiology Authors: MingJun Zhang Kathy O Lui Bin Zhou Source Type: research
TR(i)P Goes On: Auxiliary TRP Channel Subunits?
Circ Res. 2024 Feb 16;134(4):346-350. doi: 10.1161/CIRCRESAHA.123.323178. Epub 2024 Feb 15.ABSTRACTTransient receptor potential (TRP) cation channels are a diverse family of channels whose members play prominent roles as cellular sensors and effectors. The important role of TRP channels (and mechanosensitive piezo channels) in the complex interaction of our senses with the environment was underlined by the award of the Nobel Prize in Physiology or Medicine to 2 pioneers in this field, David Julius and Ardem Patapoutian. There are many competent and comprehensive reviews on many aspects of the TRP channels, and there is no ...
Source: Circulation Research - February 15, 2024 Category: Cardiology Authors: Veit Flockerzi Bernd Fakler Source Type: research
Meet the First Authors
Circ Res. 2024 Feb 16;134(4):344-345. doi: 10.1161/RES.0000000000000662. Epub 2024 Feb 15.NO ABSTRACTPMID:38359094 | DOI:10.1161/RES.0000000000000662 (Source: Circulation Research)
Source: Circulation Research - February 15, 2024 Category: Cardiology Source Type: research
Hypertension Related Co-Morbidities and Complications in Women of Sub-Saharan Africa: A Brief Review
Circ Res. 2024 Feb 16;134(4):459-473. doi: 10.1161/CIRCRESAHA.123.324077. Epub 2024 Feb 15.ABSTRACTHypertension is the leading cause of cardiovascular disease in women, and sub-Saharan African (SSA) countries have some of the highest rates of hypertension in the world. Expanding knowledge of causes, management, and awareness of hypertension and its co-morbidities worldwide is an effective strategy to mitigate its harms, decrease morbidities and mortality, and improve individual quality of life. Hypertensive disorders of pregnancy (HDPs) are a particularly important subset of hypertension, as pregnancy is a major stress tes...
Source: Circulation Research - February 15, 2024 Category: Cardiology Authors: Taija M Hahka Rebecca A Slotkowski Anum Akbar Matt C VanOrmer Lawrence Fred Sembajwe Abdul M Ssekandi Agnes Namaganda Haruna Muwonge Josephine N Kasolo Annettee Nakimuli Naome Mwesigwa Jeanne A Ishimwe Robert Kalyesubula Annet Kirabo Ann L Anderson Berry Source Type: research
Correction to: Macromolecular Complex Including MLL3, Carabin and Calcineurin Regulates Cardiac Remodeling
Circ Res. 2024 Feb 16;134(4):e2. doi: 10.1161/RES.0000000000000658. Epub 2024 Feb 15.NO ABSTRACTPMID:38359097 | DOI:10.1161/RES.0000000000000658 (Source: Circulation Research)
Source: Circulation Research - February 15, 2024 Category: Cardiology Source Type: research
Correction to: Cardiac Aging Is Promoted by Pseudohypoxia Increasing p300-Induced Glycolysis
Circ Res. 2024 Feb 16;134(4):e1. doi: 10.1161/RES.0000000000000657. Epub 2024 Feb 15.NO ABSTRACTPMID:38359098 | DOI:10.1161/RES.0000000000000657 (Source: Circulation Research)
Source: Circulation Research - February 15, 2024 Category: Cardiology Source Type: research
From Gut to Heart: Role of Indole-3-Propionic Acid in HFpEF
Circ Res. 2024 Feb 16;134(4):390-392. doi: 10.1161/CIRCRESAHA.123.323947. Epub 2024 Feb 15.NO ABSTRACTPMID:38359099 | DOI:10.1161/CIRCRESAHA.123.323947 (Source: Circulation Research)
Source: Circulation Research - February 15, 2024 Category: Cardiology Authors: Antonio Vacca Gabriele G Schiattarella Source Type: research
CHKB-DT: A Long Noncoding RNA Critical for Cardiovascular Health
Circ Res. 2024 Feb 16;134(4):442-444. doi: 10.1161/CIRCRESAHA.124.324166. Epub 2024 Feb 15.NO ABSTRACTPMID:38359100 | DOI:10.1161/CIRCRESAHA.124.324166 (Source: Circulation Research)
Source: Circulation Research - February 15, 2024 Category: Cardiology Authors: Michael L Kamradt Catherine A Makarewich Source Type: research
< em > N < /em > -Glycosylation Profiles of Immunoglobulin G and Future Cardiovascular Events
CONCLUSIONS: An IgG N-glycan profile was associated with incident CVD in 2 populations (primary and secondary prevention), involving an agalactosylated glycan associated with increased risk of CVD, while several digalactosylated and sialylated IgG glycans associated with decreased risk. An IgG glycan score was positively associated with future CVD.PMID:38348651 | DOI:10.1161/CIRCRESAHA.123.323623 (Source: Circulation Research)
Source: Circulation Research - February 13, 2024 Category: Cardiology Authors: Rosangela A Hoshi Branimir Plav ša Yanyan Liu Irena Trbojevi ć-Akmačić Robert J Glynn Paul M Ridker Richard D Cummings Ivan Gudelj Gordan Lauc Olga V Demler Samia Mora Source Type: research
Molecular and Spatial Signatures of Mouse Embryonic Endothelial Cells at Single-Cell Resolution
CONCLUSIONS: Our results provide a spatiotemporal map of embryonic EC heterogeneity at single-cell resolution and demonstrate that the diversity of ECs in the embryo arises from both tissue origin and vascular-bed position. Developing aECs and vECs share common venous-featured capillary precursors and are regulated by distinct transcriptional regulatory networks.PMID:38348657 | DOI:10.1161/CIRCRESAHA.123.323956 (Source: Circulation Research)
Source: Circulation Research - February 13, 2024 Category: Cardiology Authors: Jian Chen Xiaoran Zhang Daniel Morris DeLaughter Michael A Trembley Shaila Saifee Feng Xiao Jiehui Chen Pingzhu Zhou Christine E Seidman Jonathan G Seidman William T Pu Source Type: research
Retraction of: Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis
Circ Res. 2024 Feb 9. doi: 10.1161/RES.0000000000000663. Online ahead of print.NO ABSTRACTPMID:38333982 | DOI:10.1161/RES.0000000000000663 (Source: Circulation Research)
Source: Circulation Research - February 9, 2024 Category: Cardiology Source Type: research
Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells
CONCLUSIONS: Our results demonstrate that exercise training protects against Dox-induced cardiotoxicity by upregulating Fc gamma receptor IIB expression in B cells, which plays an important anti-inflammatory role and participates in the protective effect of exercise against Dox-induced cardiotoxicity.PMID:38323433 | DOI:10.1161/CIRCRESAHA.123.323346 (Source: Circulation Research)
Source: Circulation Research - February 7, 2024 Category: Cardiology Authors: Jing Wang Shuqin Liu Xinxiu Meng Xuan Zhao Tianhui Wang Zhiyong Lei H Immo Lehmann Guoping Li Pilar Alcaide Yihua Bei Junjie Xiao Source Type: research
Integrated Stress Response Potentiates Ponatinib-Induced Cardiotoxicity
CONCLUSIONS: Neutralizing ISR hyperactivation could prevent or reverse ponatinib-induced cardiotoxicity. The findings that compromised ATP production potentiates GCN2-mediated ISR activation have broad implications across various cardiac diseases. Our results also highlight an unanticipated role of ponatinib in causing direct activation of a kinase target despite its role as an ATP-competitive kinase inhibitor.PMID:38323474 | DOI:10.1161/CIRCRESAHA.123.323683 (Source: Circulation Research)
Source: Circulation Research - February 7, 2024 Category: Cardiology Authors: Gege Yan Zhenbo Han Youjeong Kwon Jordan Jousma Sarath Babu Nukala Benjamin L Prosser Xiaoping Du Sandra Pinho Sang-Bing Ong Won Hee Lee Sang-Ging Ong Source Type: research
LncRNA CHKB-DT Downregulation Enhances Dilated Cardiomyopathy Through ALDH2
CONCLUSIONS: CHKB-DT is significantly downregulated in DCM. CHKB-DT acts as an energy metabolism-associated long noncoding RNA and represents a promising therapeutic target against DCM.PMID:38299365 | DOI:10.1161/CIRCRESAHA.123.323428 (Source: Circulation Research)
Source: Circulation Research - February 1, 2024 Category: Cardiology Authors: Xiang Nie Jiahui Fan Beibei Dai Zheng Wen Huaping Li Chen Chen Dao Wen Wang Source Type: research
Reversal of Pulmonary Hypertension in a Human-Like Model: Therapeutic Targeting of Endothelial DHFR
CONCLUSIONS: Taken together, these results establish a novel human-like murine model of PH that has long been lacking in the field, which can be broadly used for future mechanistic and translational studies. These data also indicate that targeting endothelial DHFR deficiency represents a novel and robust therapeutic strategy for the treatment of PH.PMID:38299369 | DOI:10.1161/CIRCRESAHA.123.323090 (Source: Circulation Research)
Source: Circulation Research - February 1, 2024 Category: Cardiology Authors: Priya Murugesan Yixuan Zhang Yuanli Huang Nobel Chenggong Zong Ji Youn Youn Wenhui Chen Chen Wang Joseph Loscalzo Hua Cai Source Type: research
