SUMOylation Fine-Tunes Endothelial HEY1 in the Regulation of Angiogenesis

CONCLUSIONS: Our findings demonstrate that reversible HEY1 SUMOylation is a molecular mechanism that coordinates endothelial angiogenic signaling and angiogenesis, both in physiological and pathological milieus, by fine-tuning the transcriptional activity of HEY1. Specifically, SUMOylation facilitates the formation of the HEY1 transcriptional complex and enhances its DNA-binding capability in endothelial cells.PMID:38166414 | DOI:10.1161/CIRCRESAHA.123.323398

Source: Circulation Research - January 3, 2024 Category: Cardiology Authors: Ruizhe Ren Sha Ding Kefan Ma Yuanqing Jiang Yiran Wang Junbo Chen Yunyun Wang Yaohui Kou Xiao Fan Xiaolong Zhu Lingfeng Qin Cong Qiu Michael Simons Xiyang Wei Luyang Yu Source Type: research