Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes
CONCLUSIONS: In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04353869.PMID:38152893 | DOI:10.1161/CIRCRESAHA.123.322757 (Source: Circulation Research)
Source: Circulation Research - December 28, 2023 Category: Cardiology Authors: Jean-Baptiste Julla Diane Girard Marc Diedisheim Pierre-Jean Saulnier Bao Tran Vuong Camille Bl ériot Elena Carcarino Joe De Keizer Lucie Orliaguet Ivan Nemazanyy Charline Potier Kennan Khider Dorothy Chepngenoh Tonui Tina Ejlalmanesh Raphaelle Ballaire Source Type: research

Blood Monocyte Phenotype Is A Marker of Cardiovascular Risk in Type 2 Diabetes
CONCLUSIONS: In this study, we provide evidence that frequency and monocyte phenotypic profile are closely linked to cardiovascular risk in patients with T2D. The assessment of monocyte frequency and count is a valuable predictive marker for risk of cardiovascular events in patients with T2D.REGISTRATION: URL: https://www.clinicaltrials.gov; Unique identifier: NCT04353869.PMID:38152893 | DOI:10.1161/CIRCRESAHA.123.322757 (Source: Circulation Research)
Source: Circulation Research - December 28, 2023 Category: Cardiology Authors: Jean-Baptiste Julla Diane Girard Marc Diedisheim Pierre-Jean Saulnier Bao Tran Vuong Camille Bl ériot Elena Carcarino Joe De Keizer Lucie Orliaguet Ivan Nemazanyy Charline Potier Kennan Khider Dorothy Chepngenoh Tonui Tina Ejlalmanesh Raphaelle Ballaire Source Type: research

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Circ Res. 2023 Dec 22. doi: 10.1161/CIRCRESAHA.123.323854. Online ahead of print.NO ABSTRACTPMID:38131200 | DOI:10.1161/CIRCRESAHA.123.323854 (Source: Circulation Research)
Source: Circulation Research - December 22, 2023 Category: Cardiology Authors: P Laurette C Cao D Ramanujam M Schwaderer T Lueneburg S Kuss L Weiss R Dilshat E E M Furlong F Rezende S Engelhardt R Gilsbach Source Type: research

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Circ Res. 2023 Dec 22. doi: 10.1161/CIRCRESAHA.123.323854. Online ahead of print.NO ABSTRACTPMID:38131200 | DOI:10.1161/CIRCRESAHA.123.323854 (Source: Circulation Research)
Source: Circulation Research - December 22, 2023 Category: Cardiology Authors: P Laurette C Cao D Ramanujam M Schwaderer T Lueneburg S Kuss L Weiss R Dilshat E E M Furlong F Rezende S Engelhardt R Gilsbach Source Type: research

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Circ Res. 2023 Dec 22. doi: 10.1161/CIRCRESAHA.123.323854. Online ahead of print.NO ABSTRACTPMID:38131200 | DOI:10.1161/CIRCRESAHA.123.323854 (Source: Circulation Research)
Source: Circulation Research - December 22, 2023 Category: Cardiology Authors: P Laurette C Cao D Ramanujam M Schwaderer T Lueneburg S Kuss L Weiss R Dilshat E E M Furlong F Rezende S Engelhardt R Gilsbach Source Type: research

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Circ Res. 2023 Dec 22. doi: 10.1161/CIRCRESAHA.123.323854. Online ahead of print.NO ABSTRACTPMID:38131200 | DOI:10.1161/CIRCRESAHA.123.323854 (Source: Circulation Research)
Source: Circulation Research - December 22, 2023 Category: Cardiology Authors: P Laurette C Cao D Ramanujam M Schwaderer T Lueneburg S Kuss L Weiss R Dilshat E E M Furlong F Rezende S Engelhardt R Gilsbach Source Type: research

In Vivo Silencing of Regulatory Elements Using a Single AAV-CRISPRi Vector
Circ Res. 2023 Dec 22. doi: 10.1161/CIRCRESAHA.123.323854. Online ahead of print.NO ABSTRACTPMID:38131200 | DOI:10.1161/CIRCRESAHA.123.323854 (Source: Circulation Research)
Source: Circulation Research - December 22, 2023 Category: Cardiology Authors: P Laurette C Cao D Ramanujam M Schwaderer T Lueneburg S Kuss L Weiss R Dilshat E E M Furlong F Rezende S Engelhardt R Gilsbach Source Type: research

Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis
CONCLUSIONS: Our findings indicate that targeting metabolic dysregulation has significant implications for the treatment of age-related cardiac fibrosis and diastolic dysfunction. We further demonstrate a novel mechanism by which succinate induces fibroblast activation and apoptosis resistance by promoting PKM2 dimerization. Hence, inhibiting succinate generation or blocking its downstream effects is potentially a promising new strategy for slowing the heart aging.PMID:38112098 | DOI:10.1161/CIRCRESAHA.123.323651 (Source: Circulation Research)
Source: Circulation Research - December 19, 2023 Category: Cardiology Authors: Ziwen Wang Shu Yang Zheng Ping Yaqi Li Ting Jiang Xin Zheng Ziyuan Zhang Guan Wang Zhaochuan Liu Haimei Sun Qi Zhang Heyang Zhang Yang Gao Youxin Feng Xixi Liu Lizhuang Han Shiqi Lin Xiaowei Zhang Mengmeng Song Tong Liu Meng Tang Chenan Liu Hailun Xie Guo Source Type: research

Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis
CONCLUSIONS: Our findings indicate that targeting metabolic dysregulation has significant implications for the treatment of age-related cardiac fibrosis and diastolic dysfunction. We further demonstrate a novel mechanism by which succinate induces fibroblast activation and apoptosis resistance by promoting PKM2 dimerization. Hence, inhibiting succinate generation or blocking its downstream effects is potentially a promising new strategy for slowing the heart aging.PMID:38112098 | DOI:10.1161/CIRCRESAHA.123.323651 (Source: Circulation Research)
Source: Circulation Research - December 19, 2023 Category: Cardiology Authors: Ziwen Wang Shu Yang Zheng Ping Yaqi Li Ting Jiang Xin Zheng Ziyuan Zhang Guan Wang Zhaochuan Liu Haimei Sun Qi Zhang Heyang Zhang Yang Gao Youxin Feng Xixi Liu Lizhuang Han Shiqi Lin Xiaowei Zhang Mengmeng Song Tong Liu Meng Tang Chenan Liu Hailun Xie Guo Source Type: research

Age-Induced Accumulation of Succinate Promotes Cardiac Fibrogenesis
CONCLUSIONS: Our findings indicate that targeting metabolic dysregulation has significant implications for the treatment of age-related cardiac fibrosis and diastolic dysfunction. We further demonstrate a novel mechanism by which succinate induces fibroblast activation and apoptosis resistance by promoting PKM2 dimerization. Hence, inhibiting succinate generation or blocking its downstream effects is potentially a promising new strategy for slowing the heart aging.PMID:38112098 | DOI:10.1161/CIRCRESAHA.123.323651 (Source: Circulation Research)
Source: Circulation Research - December 19, 2023 Category: Cardiology Authors: Ziwen Wang Shu Yang Zheng Ping Yaqi Li Ting Jiang Xin Zheng Ziyuan Zhang Guan Wang Zhaochuan Liu Haimei Sun Qi Zhang Heyang Zhang Yang Gao Youxin Feng Xixi Liu Lizhuang Han Shiqi Lin Xiaowei Zhang Mengmeng Song Tong Liu Meng Tang Chenan Liu Hailun Xie Guo Source Type: research

The Role of < em > MAPRE2 < /em > and Microtubules in Maintaining Normal Ventricular Conduction
CONCLUSIONS: Genetic ablation of mapre2 led to a decrease in voltage-gated sodium channel function, a hallmark of Brugada syndrome, associated with disruption of adherens junctions, decrease of detyrosinated tubulin as a marker of microtubule stability, and changes in microtubule dynamics. Restoration of the detyrosinated tubulin fraction with ttl knockdown led to rescue of voltage-gated sodium channel-related functional parameters in mapre2 knockout hearts. Taken together, our study implicates microtubule dynamics in the modulation of ventricular conduction.PMID:38095085 | DOI:10.1161/CIRCRESAHA.123.323231 (Source: Circulation Research)
Source: Circulation Research - December 14, 2023 Category: Cardiology Authors: David Y Chiang Arie O Verkerk Rachelle Victorio Boris I Shneyer Babet van der Vaart Mariam Jouni Nakul Narendran Ashmita Kc James R Sampognaro Franki Vetrano-Olsen John S Oh Eva Buys Berend de Jonge Disheet A Shah Tuomas Kiviniemi Paul W Burridge Connie R Source Type: research

Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function
CONCLUSIONS: We have demonstrated that tyrosine kinase phosphorylation of TnI is a novel mechanism to directly and beneficially accelerate myocardial relaxation in vivo.PMID:38095088 | DOI:10.1161/CIRCRESAHA.123.323132 (Source: Circulation Research)
Source: Circulation Research - December 14, 2023 Category: Cardiology Authors: Lorien G Salyer Hussam E Salhi Elizabeth A Brundage Vikram Shettigar Sarah L Sturgill Helena Zanella Benjamin Templeton Eaman Abay Kathryn M Emmer Jeovanna Lowe Jill A Rafael-Fortney Narasimham Parinandi D Brian Foster Timothy A McKinsey Kathleen C Woulfe Source Type: research

The Role of < em > MAPRE2 < /em > and Microtubules in Maintaining Normal Ventricular Conduction
CONCLUSIONS: Genetic ablation of mapre2 led to a decrease in voltage-gated sodium channel function, a hallmark of Brugada syndrome, associated with disruption of adherens junctions, decrease of detyrosinated tubulin as a marker of microtubule stability, and changes in microtubule dynamics. Restoration of the detyrosinated tubulin fraction with ttl knockdown led to rescue of voltage-gated sodium channel-related functional parameters in mapre2 knockout hearts. Taken together, our study implicates microtubule dynamics in the modulation of ventricular conduction.PMID:38095085 | DOI:10.1161/CIRCRESAHA.123.323231 (Source: Circulation Research)
Source: Circulation Research - December 14, 2023 Category: Cardiology Authors: David Y Chiang Arie O Verkerk Rachelle Victorio Boris I Shneyer Babet van der Vaart Mariam Jouni Nakul Narendran Ashmita Kc James R Sampognaro Franki Vetrano-Olsen John S Oh Eva Buys Berend de Jonge Disheet A Shah Tuomas Kiviniemi Paul W Burridge Connie R Source Type: research

Troponin I Tyrosine Phosphorylation Beneficially Accelerates Diastolic Function
CONCLUSIONS: We have demonstrated that tyrosine kinase phosphorylation of TnI is a novel mechanism to directly and beneficially accelerate myocardial relaxation in vivo.PMID:38095088 | DOI:10.1161/CIRCRESAHA.123.323132 (Source: Circulation Research)
Source: Circulation Research - December 14, 2023 Category: Cardiology Authors: Lorien G Salyer Hussam E Salhi Elizabeth A Brundage Vikram Shettigar Sarah L Sturgill Helena Zanella Benjamin Templeton Eaman Abay Kathryn M Emmer Jeovanna Lowe Jill A Rafael-Fortney Narasimham Parinandi D Brian Foster Timothy A McKinsey Kathleen C Woulfe Source Type: research

The Role of < em > MAPRE2 < /em > and Microtubules in Maintaining Normal Ventricular Conduction
CONCLUSIONS: Genetic ablation of mapre2 led to a decrease in voltage-gated sodium channel function, a hallmark of Brugada syndrome, associated with disruption of adherens junctions, decrease of detyrosinated tubulin as a marker of microtubule stability, and changes in microtubule dynamics. Restoration of the detyrosinated tubulin fraction with ttl knockdown led to rescue of voltage-gated sodium channel-related functional parameters in mapre2 knockout hearts. Taken together, our study implicates microtubule dynamics in the modulation of ventricular conduction.PMID:38095085 | DOI:10.1161/CIRCRESAHA.123.323231 (Source: Circulation Research)
Source: Circulation Research - December 14, 2023 Category: Cardiology Authors: David Y Chiang Arie O Verkerk Rachelle Victorio Boris I Shneyer Babet van der Vaart Mariam Jouni Nakul Narendran Ashmita Kc James R Sampognaro Franki Vetrano-Olsen John S Oh Eva Buys Berend de Jonge Disheet A Shah Tuomas Kiviniemi Paul W Burridge Connie R Source Type: research