Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
Age-Dependent RGS5 Loss in Pericytes Induces Cardiac Dysfunction and Fibrosis
CONCLUSIONS: Our results have identified RGS5 as a crucial regulator of pericyte function during cardiac aging. The deletion of RGS5 causes cardiac dysfunction and induces myocardial fibrosis, one of the hallmarks of cardiac aging.PMID:38563133 | DOI:10.1161/CIRCRESAHA.123.324183 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Anita Tamiato Lukas S Tombor Ariane Fischer Marion Muhly-Reinholz Leah Rebecca Vanicek B üşra Nur Toğru Jessica Neitz Simone Franziska Glaser Maximilian Merten David Rodriguez Morales Jeonghyeon Kwon Stephan Klatt Bianca Schumacher Stefan G ünther Wes Source Type: research
Endothelial PTP1B Deletion Promotes VWF Exocytosis and Venous Thromboinflammation
CONCLUSIONS: Our findings show that endothelial PTP1B deletion promotes venous thromboinflammation by enhancing SNAP23 phosphorylation, endothelial VWF exocytosis, and neutrophil recruitment.PMID:38563147 | DOI:10.1161/CIRCRESAHA.124.324214 (Source: Circulation Research)
Source: Circulation Research - April 2, 2024 Category: Cardiology Authors: Konstantinos Zifkos Magdalena L Bochenek Rajinikanth Gogiraju Stephane Robert Denise Pedrosa Klytaimnistra Kiouptsi Kateryna Moiko Mathias Wagner Felix Mahfoud Philippe Poncelet Thomas M ünzel Wolfram Ruf Christoph Reinhardt Laurence Panicot-Dubois Chris Source Type: research
CD151 Maintains Endolysosomal Protein Quality to Inhibit Vascular Inflammation
CONCLUSIONS: Distinct from its canonical function in strengthening cell adhesion at cell surface, CD151 maintains endolysosome function by sustaining VCP/p97-mediated protein unfolding and turnover. By supporting protein quality control and protein degradation, CD151 prevents proteins from (1) buildup in endolysosomes and (2) discharge through exosomes, to limit vascular inflammation. Also, our study conceptualizes that balance between degradation and discharge of proteins in endothelial cells determines vascular information. Thus, the IFITM3/V-ATPase-tetraspanin-VCP/p97 complexes on endolysosome, as a protein quality cont...
Source: Circulation Research - April 1, 2024 Category: Cardiology Authors: Junxiong Chen Yingjun Ding Chao Jiang Rongmei Qu Jonathan D Wren Constantin Georgescu Xuejun Wang Darlene N Reuter Beibei Liu Cory B Giles Christoph H Mayr Herbert B Schiller Jingxing Dai Christopher S Stipp Bharathiraja Subramaniyan Jie Wang Houjuan Zuo Source Type: research
Gut Microbiota and Blood Metabolites Related to Fiber Intake and Type 2 Diabetes
CONCLUSIONS: Among United States Hispanics/Latinos, dietary fiber intake was associated with favorable profiles of gut microbiota and circulating metabolites for T2D. These findings advance our understanding of the role of gut microbiota and microbial metabolites in the relationship between diet and T2D.PMID:38547246 | DOI:10.1161/CIRCRESAHA.123.323634 (Source: Circulation Research)
Source: Circulation Research - March 28, 2024 Category: Cardiology Authors: Zheng Wang Brandilyn A Peters Bing Yu Megan L Grove Tao Wang Xiaonan Xue Bharat Thyagarajan Martha L Daviglus Eric Boerwinkle Gang Hu Yasmin Mossavar-Rahmani Carmen R Isasi Rob Knight Robert D Burk Robert C Kaplan Qibin Qi Source Type: research
Untangling Complexity: Gut Microbiota, Metabolites, and Fiber Intake in Type 2 Diabetes
Circ Res. 2024 Mar 29;134(7):855-857. doi: 10.1161/CIRCRESAHA.124.324333. Epub 2024 Mar 28.NO ABSTRACTPMID:38547248 | DOI:10.1161/CIRCRESAHA.124.324333 (Source: Circulation Research)
Source: Circulation Research - March 28, 2024 Category: Cardiology Authors: Nathan T Greenberg Vienna E Brunt Source Type: research
