Research Progress of Lung Cancer Vaccines
This article reviews the recent developments of tumor vaccines of different types, starts with lung cancer and summarizes the achievements of tumor vaccines in clinical applications, and provides an outlook for the future development of antigen-centered tumor vaccines.
DOI: 10.3779/j.issn.1009-3419.2023.106.19 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Drug Resistance Mechanism and Therapeutic Strategy of Targeted Therapy of
Non-small Cell Lung Cancer with MET Alterations
Mesenchymal to epithelial transition factor (MET) gene alterations involve in the proliferation, invasion, and metastasis of non-small cell lung cancer. MET-tyrosine kinase inhibitors (TKIs) have been approved to treat non-small cell lung cancer with MET alterations, and resistance to these TKIs is inevitable. Molecular mechanisms of resistance to MET-TKIs are completely unclear. The review focused on potential mechanisms of MET-TKIs resistance and therapeutics strategies to delay and prevent resistance.
DOI: 10.3779/j.issn.1009-3419.2023.102.33 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Identification of SULF1 as a Shared Gene in Idiopathic Pulmonary Fibrosis
and Lung Adenocarcinoma
Conclusions This study identified a set of shared molecular pathways and core genes between IPF and LUAD. Notably, SULF1 may serve as a potential immune-related biomarker and therapeutic target for both diseases.
DOI: 10.3779/j.issn.1009-3419.2023.101.25 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Evaluation of Efficacy and Prognosis Analysis of Stage III-IV SMARCA4-deficient
Non-small Cell Lung Cancer Treated by PD-1 Immune Checkpoint Inhibitors plus
Chemotherapy and Chemotherapy
Conclusion Treatment regimen may be a prognostic factor for patients with SMARCA4-DNSCLC, and patients with PD-1 ICIs plus chemotherapy may have a better prognosis.
DOI: 10.3779/j.issn.1009-3419.2023.101.26 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Analysis of Clinicopathological Features on Spread Through Air Spaces
of Lung Adenocarcinoma
Background and objective The biological and molecular characteristics of spread through air spaces (STAS), a newly recognized invasive mode of lung cancer, remain controversial. The aim of this study was to investigate the clinicopathological features and molecular characteristics of STAS in patients with pulmonary adenocarcinoma. Methods A total of 694 resected invasive non-mucinous lung adenocarcinomas diagnosed by clinicopathology from July 2019 to March 2021 in the First Affiliated Hospital of Guangzhou Medical University were collected, and the relationship between STAS and clinicopathological factors was analyzed. Th...
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Impacts of LncRNA NORAD on the Proliferation, Apoptosis, and Chemosensitivity of Non-small Cell Lung Cancer Cells by Regulating ZNF217 through MiR-199a-3p
Background and objective The treatment and diagnosis of non-small cell lung cancer (NSCLC) is still a difficult problem in the medical community, and exploring the molecular mechanism of the occurrence and development of NSCLC is a hot topic of the current research. Long non-coding RNA (lncRNA) NORAD is highly expressed in a variety of cancer cells. It may be a molecular target that promotes NSCLC. The aim of this study was to investigate the impacts of lncRNA NORAD on the proliferation, apoptosis, and chemosensitivity of NSCLC by regulating zinc finger protein 217 (ZNF217) through miR-199a-3p. Methods Real-time quantitati...
Source: Chinese Journal of Lung Cancer - September 1, 2023 Category: Cancer & Oncology Source Type: research
Progress in Image-planned and Real-time Image-guided Lung Cancer Biopsy
in the Detection of Biomarkers
With the progress of targeted therapy and immunotherapy for lung cancer, the clinical demand for lung biopsy is increasing. An ideal biopsy specimen can be used not only for histopathological diagnosis, but also for biomarker detection. The ideal biopsy specimen should meet two requirements, including more than 60 mm2 of tumor tissue and containing more than 20% of tumor cells. In order to obtain ideal lung cancer biopsy specimens, advanced imaging techniques are needed to help. In this article, we reviewed the requirements for biopsy specimens based on biomarker detection, as well as the current status and research progre...
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Recent Advances and Controversies in Minute Pulmonary Meningothelial-like Nodules
Minute pulmonary meningothelial-like nodules (MPMNs) are benign small lesions in the lungs, with similar pathological characteristics to the meningeal epithelium. MPMNs have similar imaging manifestations to malignant tumors, which can lead to misdiagnosis in clinical practice. There is no consensus on the pathogenesis of MPMNs, with some suggest that MPMNs derive from reactive proliferation, while others suggest that MPMNs share a common origin and molecular mechanism with meningiomas in the central nervous system. Understanding the characteristics of MPMNs and studying their pathogenesis will help improve the understandi...
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Recent Progress of Tertiary Lymphoid Structure in Prognosis and Immunotherapy of Non-small Cell Lung Cancer
This article provides a review of the prognostic role of tertiary lymphoid structures in immunotherapy of NSCLC, in order to offer references for screening suitable candidates for immunotherapy of NSCLC and develop personalized and precise treatment plans.
DOI: 10.3779/j.issn.1009-3419.2023.101.23 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Peripheral Blood Laboratory Test Results Combined with TCF1+CD8+ T Lymphocytes
Ratio to Predict the Response and Prognosis of Immunotherapy to
Advanced Lung Cancer
This study aimed to investigate the correlation of peripheral blood laboratory test results combined with lymphocyte subset ratios to the response and prognosis of immunotherapy in advanced lung cancer. Methods Advanced lung cancer patients admitted to West China Hospital, Sichuan University from May 2021 to July 2023 were prospectively enrolled in this study. Clinical data and peripheral blood were collected before and after treatment and lymphocyte subset ratios were analyzed by flow cytometry. Logistic regression was used to identify factors correlated to ICIs treatment efficacy. Cox modeling was applied to explore the ...
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Construction of Lung Adenocarcinoma Prognosis Model and Drug Sensitivity Analysis Based on Cuproptosis Related Genes
Conclusion The risk model constructed based on 13 CRGs has good prognostic value, which can assist LUAD patients in individualized treatment, and provides an important theoretical basis for the treatment and prognosis of LUAD.
DOI: 10.3779/j.issn.1009-3419.2023.102.31 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Exploring the Role of DKK1 in the Occurrence of Lung Adenocarcinoma Based on the Analysis of Bioinformatics
Conclusion High expression of DKK1 in lung adenocarcinoma is associated with poor prognosis. DKK1 is closely associated with tumor immune cell infiltration and pathways. DKK1 can be considered as a potential prognostic marker and a novel target for immunotherapy of lung adenocarcinoma.
DOI: 10.3779/j.issn.1009-3419.2023.101.22 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Application of Rapid HE Staining in Cytological Rapid On-site Evaluation of
Peripheral Lung Cancer Needle Biopsy
Conclusion Both staining methods comply with C-ROSE criteria in the biopsy setting of peripheral lung cancer. Rapid HE staining is more aligned with domestic clinical requirements and holds potential for further promotion and adoption in C-ROSE.
DOI: 10.3779/j.issn.1009-3419.2023.101.24 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - August 20, 2023 Category: Cancer & Oncology Source Type: research
Updated Interpretation of the NCCN Clinical Practice Guidelines (Version 3. 2023)
for Non-small Cell Lung Cancer
This article will interpret the main updated contents of the new edition of the guidelines, and compare it with the third edition of the NCCN guidelines in 2022, so as to provide references about the diagnosis and treatment of NSCLC for clinical medical personnel in China.
DOI: 10.3779/j.issn.1009-3419.2023.102.18 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 25, 2023 Category: Cancer & Oncology Source Type: research
Erratum: China National Guideline of Classification, Diagnosis and Treatment for Lung Nodules (2016 Version)
Zhou QH, Fan YG, Wang Y, et al. Zhongguo Fei Ai Za Zhi, 2016, 19(12): 793-798. In the version of this article initially published, error appeared on page 795. The first sentence in part 3.1.2 should be “标准：直径介于5 mm-15 mm且无明显恶性CT征象的实性结节”. DOI: 10.3779/j.issn.1009-3419.2023.103.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - July 20, 2023 Category: Cancer & Oncology Source Type: research
