Research Progress on Tumor Metabolic Biomarkers in Liquid Biopsy of Lung Cancer
This article summarizes the changes in the main metabolic pathways of lung cancer, including glucose metabolism, amino acid metabolism, lipid metabolism, sphingolipid metabolism, glycerophospholipid metabolism, and purine metabolism. Meanwhile, this article reviews the role of metabolic biomarkers in the early diagnosis of lung cancer, predicting disease progression, and evaluating the efficacy of chemotherapy and immunotherapy, aiming to provide effective biomarkers for tumor diagnosis and treatment.
DOI: 10.3779/j.issn.1009-3419.2023.106.29 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Value of CT Quantitative Parameters in Prediction of Pathological Types
of Lung Ground Glass Nodules
Conclusion AI quantitative parameters were valuable in distinguishing the pathological types of GGNs.
DOI: 10.3779/j.issn.1009-3419.2024.102.09 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Expression of FAT1 in Lung Adenocarcinoma and Its Relationship
with Immune Cell Infiltration
Conclusion FAT1 mRNA is highly expressed in lung adenocarcinoma tissues, and elevated FAT1 mRNA expression is associated with poor prognosis in lung adenocarcinoma patients. FAT1 may serve as a potential biomarker for lung cancer.
DOI: 10.3779/j.issn.1009-3419.2024.102.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Effect of Preserving the Pulmonary Branch of Vagus Nerve on Postoperative Cough
in Patients with Stage I Peripheral Lung Adenocarcinoma
Background and objective Cough is one of the main complications after pulmonary surgery, which seriously affects the postoperative quality of life. Preserving the pulmonary branch of vagus nerve may reduce the incidence of postoperative cough. Therefore, the aim of this study was to investigate whether preserving the pulmonary branch of the vagus nerve could reduce the incidence of postoperative chronic cough in patients with stage I peripheral lung adenocarcinoma. Methods A total of 125 patients who underwent single-port thoracoscopic radical resection for lung cancer in the Department of Thoracic Surgery, The First Affil...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Role of General Anesthesia and Rapid On-site Evaluation
in the Diagnosis of Lung Cancer with EBUS-TBNA
Conclusion Compared to the combination of local anesthesia with intravenous analgesia and sedation, the implementation of EBUS-TBNA under general anesthesia, with or without ROSE, achieves equally accurate results, and general anesthesia combined with ROSE can reduce in the number of lymph node puncture needles.
DOI: 10.3779/j.issn.1009-3419.2024.102.07 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
Epidemiological Characteristics of Lung Cancer Incidence
in the Tumor Registration Area of Gansu Province from 2010 to 2019
Background and objective Lung cancer is the malignant tumor with the highest incidence rate and the heaviest disease burden in China. In recent years, lung cancer has shown a high incidence trend, seriously affecting the health of the population. In this paper, we analyze the characteristics of lung cancer incidence in 2019 and the trend of incidence rate from 2010-2019 in the tumor registration area of Gansu province, in order to provide a reference basis for the development of lung cancer prevention and control strategies in Gansu province. Methods By analyzing the cases of lung cancer incidence in the tumor registration...
Source: Chinese Journal of Lung Cancer - February 20, 2024 Category: Cancer & Oncology Source Type: research
TRIP13 Enhances Radioresistance of Lung Adenocarcinoma Cells
through the Homologous Recombination Pathway
This study aimed to identify the molecules associated with radioresistance in lung adenocarcinoma (LUAD), identified thyroid hormone receptor interactor 13 (TRIP13) as the main target initially, and explored whether TRIP13 is related to radioresistance in LUAD and the specific mechanism, with the aim of providing theoretical basis and potential targets for the combination therapy of LUAD patients receiving radiotherapy in the clinic. Methods Three datasets, GSE18842, GSE19188 and GSE33532, were selected from the Gene Expression Omnibus (GEO) database and screened for differentially expressed genes (|log FC|>1.5, P (Source:...
Source: Chinese Journal of Lung Cancer - February 1, 2024 Category: Cancer & Oncology Source Type: research
Progress of BRAF Gene Alteration in Non-small Cell Lung Cancer
This article reviewed the progress in structural characteristics, related signaling pathways, mutation types of BRAF gene, and the clinical pathological relationship between BRAF mutations and NSCLC, as well as the therapy, in order to provide more evidences for clinical doctors to make treatment decisions.
DOI: 10.3779/j.issn.1009-3419.2024.101.01 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Research Progress of Granulocytic Myeloid-derived Suppressor Cells
in Non-small Cell Lung Cancer
This article reviews the immunosuppressive effect of G-MDSCs in non-small cell lung cancer and the progress of related pathway targeting drugs.
DOI: 10.3779/j.issn.1009-3419.2023.106.28 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Establishment of a 21-color Panel for the Detection of Immune Cell Subsets
in Human Non-small Cell Lung Cancer Tumor Tissues with Flow Cytometry
Conclusion The successfully established 21-color flow cytometry protocol is suitable for the detection of PBMCs and NSCLC tissue samples, which provides an effective new idea for monitoring the immune microenvironment status in lung cancer.
DOI: 10.3779/j.issn.1009-3419.2024.102.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Construction of a Prognostic Prediction Model of Patients with Pathologic N0
in Resected Invasive Mucinous Adenocarcinoma of the Lung
Conclusion The Nomograms based on clinicopathological characteristics in a certain extent, can be used as an effective prognostic tool for patients with pathologic N0 after IMA resection.
DOI: 10.3779/j.issn.1009-3419.2024.106.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Establishment of a Predictive Model for Chronic Cough after Pulmonary Resection
Conclusion Chronic cough after pulmonary resection seriously affects the quality of life of patients. The visual presentation form of the Nomogram is helpful to accurately predict chronic cough after pulmonary resection and provide support for clinical decision-making.
DOI: 10.3779/j.issn.1009-3419.2024.101.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Identification and Analysis of SND1 as an Oncogene and Prognostic Biomarker
for Lung Adenocarcinoma
Conclusion SND1 might be an important prognostic biomarker of LUAD and may promote LUAD cells proliferation and migration.
DOI: 10.3779/j.issn.1009-3419.2023.102.47 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Effectiveness Evaluation of Low-dose Spiral Computed Tomography
for Lung Cancer Screening in Minhang District of Shanghai
This study aimed to evaluate the effectiveness in Chinese adults based on the Lung Cancer Screening Program in Minhang District of Shanghai initiated in 2013. Methods A total of 26,124 subjects aged 40 years or above were enrolled in the Lung Cancer Screening Program during the period of 2013 and 2017. Results of LDCT examination, and screen-detected cancer cases in all participants were obtained from the Reporting System of the Lung Cancer Screening Program. The newly-diagnosed cases and their vital status up to December 31, 2020 were identified through a record linkage with the Shanghai Cancer Registry and the Shanghai V...
Source: Chinese Journal of Lung Cancer - January 20, 2024 Category: Cancer & Oncology Source Type: research
Impact of Folic Acid on the Resistance of Non-small Cell Lung Cancer Cells
to Osimertinib by Regulating Methylation of DUSP1
This study was conducted to investigate the effect of folic acid (FA) on the resistance of non-small cell lung cancer (NSCLC) cells to Osimertinib (OSM) by regulating the methylation of dual specificity phosphatase 1 (DUSP1). Methods The OSM resistant NSCLC cell line PC9R was establishd by gradually escalation of OSM concentration in PC9 cells. PC9R cells were randomly grouped into Control group, OSM group (5 μmol/L OSM), FA group (600 nmol/L FA), methylation inhibitor decitabine (DAC) group (10 μmol/L DAC), FA+OSM group (600 nmol/L FA+5 μmol/L OSM), and FA+OSM+DAC group (600 nmol/L FA+5 μmol/L OSM+10 μmol/L DAC). CCK...
Source: Chinese Journal of Lung Cancer - January 2, 2024 Category: Cancer & Oncology Source Type: research
