A Case of New Rapidly Progressing Ground-glass Nodule Lung Adenocarcinoma Near Primary Lesion after Stereotactic Body Radiation Therapy
We present a successful case of GGN lung cancer treated with SBRT, but a new GGN was found in the lung adjacent to the SBRT target during follow-up. The nodule progressed rapidly and was confirmed as lung adenocarcinoma by surgical resection. No significant risk factors and related driving genes were found in molecular pathological findings and genetic tests. It deserves further study whether new GGN is related to the SBRT. This case suggests that the follow-up after SBRT should be vigilant against the occurrence of new rapidly progressive lung cancer in the target area and adjacent lung tissue.
DOI: 10.3779/j.issn.100...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Relationship between Bacteria in the Lower Respiratory Tract/Lung Cancer
and the Development of Lung Cancer as well as Its Clinical Application
Due to the advancement of 16S rRNA sequencing technology, the lower respiratory tract microbiota, which was considered non-existent, has been revealed. The correlation between these microorganisms and diseases such as tumor has been a hot topic in recent years. As the bacteria in the surrounding can infiltrate the tumors, researchers have also begun to pay attention to the biological behavior of tumor bacteria and their interaction with tumors. In this review, we present the characteristic of the lower respiratory tract bacteria and summarize recent research findings on the relationship between these microbiota and lung ca...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Hypothesis of Genetic Diversity Selection in the Occurrence and Development of
Lung Cancer: Molecular Evolution and Clinical Significance
This article proposed the hypothesis of genetic diversity selection and analyzed its clinical significance.
DOI: 10.3779/j.issn.1009-3419.2023.101.34 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Progress of Immunotherapy in EGFR-mutated Advanced Non-small Cell Lung Cancer
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are currently the first-line standard of care for patients with non-small cell lung cancer (NSCLC) that harbor EGFR mutations. Nevertheless, resistance to EGFR-TKIs is inevitable. In recent years, although immune checkpoint inhibitors (ICIs) have significantly shifted the treatment paradigm in advanced NSCLC without driver mutation, clinical benefits of these agents are limited in patients with EGFR-mutated NSCLC. Compared with wild-type tumors, tumors with EGFR mutations show more heterogeneity in the expression level of programmed cell death ligand 1...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Study on the Role and Mechanism of METTL3 Mediating the Up-regulation of
m6A Modified Long Non-coding RNA THAP7-AS1 in Promoting the Occurrence of
Lung Cancer
Background and objective Lung cancer is a major threat to human health. The molecular mechanisms related to the occurrence and development of lung cancer are complex and poorly known. Exploring molecular markers related to the development of lung cancer is helpful to improve the effect of early diagnosis and treatment. Long non-coding RNA (lncRNA) THAP7-AS1 is known to be highly expressed in gastric cancer, but has been less studied in other cancers. The aim of the study is to explore the role and mechanism of methyltransferase-like 3 (METTL3) mediated up-regulation of N6-methyladenosine (m6A) modified lncRNA THAP7-AS1 exp...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Cytology Smears of Rapid On-site Evaluation as Supplemental Material
for Molecular Testing of Non-small Cell Lung Cancer
Conclusion ROSE smear samples of the thoracic small biopsies are beneficial supplemental materials for ancillary testing of lung cancer. Combined use of cytology smear samples with traditional FFPE section samples can enhance the detection rate of informative mutations in patients with advanced NSCLC. We recommend that the laboratory could further evaluate the ROSE cell smears of the patient when FFPE tissue sections are inadequate, and that adequate cell smears can be used as a supplemental source for the molecular testing of NSCLC.
DOI: 10.3779/j.issn.1009-3419.2023.101.35 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Predictive Value of Peripheral Blood Biomarkers in the Treatment of
Lung Cancer Patients with Anti PD-1 Immunotherapy
Conclusion Peripheral blood serum IFN-γ, TNF-α and IL-5 in lung cancer patients have cert ain roles in predicting the clinical efficacy of anti-PD-1 therapy. The decrease in absolute peripheral blood lymphocyte count in lung cancer patients is related to disease progression, but large-scale prospective studies are needed to further elucidate the value of these biomarkers.
DOI: 10.3779 /j.issn.1009-3419.2023.102.38 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Mutational Signatures Analysis of Micropapillary Components and Exploration of ZNF469 Gene in Early-stage Lung Adenocarcinoma with Ground-glass Opacities
Background and objective In China, lung cancer remains the cancer with the highest incidence and mortality rate. Among early-stage lung adenocarcinomas (LUAD), the micropapillary (MPP) component is prevalent and typically exhibits high aggressiveness, significantly correlating with early metastasis, lymphatic infiltration, and reduced five-year survival rates. Therefore, the study is to explore the similarities and differences between MPP and non-micropapillary (non-MPP) components in malignant pulmonary nodules characterized by GGOs in early-stage LUAD, identify unique mutational features of the MPP component and analyze ...
Source: Chinese Journal of Lung Cancer - December 20, 2023 Category: Cancer & Oncology Source Type: research
Chinese Expert Consensus on the Clinical Practice of Non-small Cell Lung Cancer
Fusion Gene Detection Based on RNA-based NGS
RNA-based next-generation sequencing (NGS) has been recommended as a method for detecting fusion genes in non-small cell lung cancer (NSCLC) according to clinical practice guidelines and expert consensus. The primary targetable alterations in NSCLC consist of gene mutations and fusions, making the detection of gene mutations and fusions indispensable for assessing the feasibility of targeted therapies. Currently, the integration of DNA-based NGS and RNA-based NGS allows for simultaneous detection of gene mutations and fusions and has been partially implemented in clinical practice. However, standardized guidelines and crit...
Source: Chinese Journal of Lung Cancer - December 8, 2023 Category: Cancer & Oncology Source Type: research
miR-218-5p Targeting TPX2 Regulates p53 Pathway and Inhibits Malignant Progression of Lung Adenocarcinoma
Conclusion miR-218-5p targets and inhibits TPX2 expression and exerts an inhibitory effect on the malignant progression of LUAD cells via p53.
DOI: 10.3779/j.issn.1009-3419.2023.101.30 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 21, 2023 Category: Cancer & Oncology Source Type: research
Research Progress on the Combination Therapy of EGFR-TKIs and Metformin
in Acquired Resistance to EGFR-TKIs in Non-small Cell Lung Cancer
Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) targeting EGFR are effective in EGFR mutation-positive non-small cell lung cancer (NSCLC) patients, but drug resistance is inevitable. With the application and expansion of individualized and combined therapy, more and more studies have shown that combined administration of Metformin effectively solves the problem of acquired drug resistance to EGFR-TKIs in clinical treatment and prolongs the survival of patients with NSCLC. EGFR-TKIs combined with Metformin is expected to be the treatment method of choice for NSCLC patients with EGFR-TKIs resistance. ...
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
Recent Advances in Diagnosis and Treatment Strategies for Multiple Primary Lung Cancer
As the utilization of computed tomography in lung cancer screening becomes more prevalent in the post-pandemic era, the incidence of multiple primary lung cancer (MPLC) has surged in various countries and regions. Despite the continued application of advanced histologic and sequencing technologies in this research field, the differentiation between MPLC and intrapulmonary metastasis (IM) remains challenging. In recent years, the specific mechanisms of genetic and environmental factors in MPLC have gradually come to light. Lobectomy still predominates in the treatment of MPLC, but the observation that tumor-specific subloba...
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
Research Progress of LncRNA SNHGs in Regulating the Biological Behavior
of Non-small Cell Lung Cancer
Lung cancer is one of the malignant tumors with the highest incidence and mortality rate in China, and its occurrence and development mechanism and treatment methods are the current research focuses. In recent years, the emergence of drugs targeting various tumor driver genes has significantly improved patients ’ survival and quality of life, setting off a wave of research on new therapeutic targets. Among them, long non-coding RNA (lncRNA) plays a crucial role in the malignant behavior of tumors, which has attracted widespread attention. Shown by a large number of studies, partial members of lncRNA smal l nucleolar RNA ...
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
Comparison of Quality of Life of the Patients Three Months after Uniportal
and Multiportal Thoracoscopic Lobectomy
Conclusion Patients undergoing uniportal and multiportal thoracoscopic lobectomy have similar quality of life at three months postoperatively. The uniportal group may have certain advantages in terms of traditional clinical outcome indicators such as operation time, postoperative hospital stay, and early postoperative complications.
DOI: 10.3779/j.issn.1009-3419.2023.102.42 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
Construction of A Nomogram Prediction Model for PD-L1 Expression
in Non-small Cell Lung Cancer Based on 18F-FDG PET/CT Metabolic Parameters
Conclusion The Nomogram prediction model constructed on the basis of 18F-FDG PET/CT metabolic parameters has greater application value in predicting PD-L1 expression in NSCLC patients.
DOI: 10.3779/j.issn.1009-3419.2023.101.32 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
