Application of Neoadjuvant Chemoimmunotherapy in Resectable NSCLC
This study aimed to investigate the safety and feasibility of this approach in the real world. Methods Clinical data from patients with NSCLC who underwent surgery after neoadjuvant chemoimmunotherapy or chemotherapy alone in two centers were analyzed retrospectively, and subgroup analyses were performed for the chemoimmunotherapy group according to treatment cycle. The primary study endpoints were EFS and major pathologic response (MPR), and the secondary study endpoints were pCR, overall survival (OS), treatment-related adverse events (TRAEs), and surgery-related metrics. Results As of April 2023, 89 patients had been en...
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
Mechanism of miR-186-5p Regulating PRKAA2 to Promote Ferroptosis
in Lung Adenocarcinoma Cells
Conclusion miR-186-5p promotes ferroptosis of LUAD cells through targeted regulation of PRKAA2, thus inhibiting the proliferation, invasion and migration of LUAD.
DOI: 10.3779/j.issn.1009-3419.2023.102.39 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 20, 2023 Category: Cancer & Oncology Source Type: research
A Novel Chinese Medicine Formula Inhibits Non-small Cell Lung Cancer by Triggering Oxidative Stress Dependent on Pentose Phosphate Pathway
Conclusion NCHF-01 can inhibit NSCLC through oxidative stress dependent on the PPP.
DOI: 10.3779/j.issn.1009-3419.2023.101.27 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 25, 2023 Category: Cancer & Oncology Source Type: research
A Rare Case of Lung Adenocarcinoma with EGFR L833V/H835L Co-mutation
and Literature Review
Epidermal growth factor receptor (EGFR) mutations are the most common driver genes in the development of non-small cell lung cancer (NSCLC), of which mutations in exons 18-21 are frequent, especially the loss of exon 19 and exon 21 L858R mutation are the most frequent. Other rare gene mutations are rare. Simultaneous occurrence of two or more rare EGFR mutations are extremely rare in lung cancer, and the incidence of EGFR L833V/H835L rare gene compound mutations is very low, and there is little clinical data and evidence of relevant treatment methods. Some EGFR-tyrosine kinase inhibitors (EGFR-TKIs) are effective in treati...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Advances in Predictive Research of Immune Checkpoint Inhibitors-related
Adverse Events
The era of tumor treatment has been revolutionized by the advent of immune checkpoint inhibitors. However, while immunotherapy benefits patients, it can also lead to immune-related adverse events that may affect multiple organs and systems throughout the body, potentially even posing a life-threatening risk. The diverse clinical manifestations and onset times of these adverse events further complicate their prediction and diagnosis. The purpose of this paper is to review the clinical characteristics and predicted biomarkers of adverse events related to inhibitors at immune checkpoints, in order to help clinicians evaluate ...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Research Progress of BRAF Fusion in Non-small Cell Lung Cancer
In advanced non-small cell lung cancer (NSCLC), V-Raf murine sarcoma viral oncogene homolog B1 (BRAF) mutation is highly malignant and has poor prognosis, and currently Dabrafenib in combination with Trametinib is approved for first-line treatment of patients with BRAF V600 mutation. In addition to mutations, BRAF fusion can also occur. With the development of gene detection, the detection of BRAF fusion is gradually increasing, but there is a lack of effective therapeutic strategies for BRAF fusion. In this paper, we review the clinical characteristics, mechanism of action, and clinical treatment of BRAF fusion to provide...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Progress in Diagnosis and Treatment of Lung Cancer Associated with Cystic Airspaces
Lung cancer associated with cystic airspaces (LCCA) is a type of lung cancer characterized by the presence of cystic cavities in or around the tumor on imaging. Due to its high potential for misdiagnosis or underdiagnosis, the prognosis of LCCA patients is poor, necessitating further large-scale clinical studies to elucidate its characteristics. Currently, four imaging classification systems exist, and there has been a progressive increase in attention towards LCCA, particularly with regard to the study of its imaging features. The results indicate a correlation between the pathological features and imaging findings of LCC...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Research Progress of Nrf2 and Ferroptosis in Tumor Drug Resistance
Lung cancer is one of the most common cancers in the world, and its treatment strategy is mainly surgery combined with radiotherapy and chemotherapy. However, long-term chemotherapy will result in drug resistance, which is also one of the difficulties in the treatment of lung cancer. Ferroptosis is an iron-dependent and lipid peroxidation-driven non-apoptotic cell death cascade, occurring when there is an imbalance of redox homeostasis in the cell. Nuclear factor erythroid 2-related factor 2 (Nrf2) is key for cellular antioxidant responses. Numerous studies suggest that Nrf2 assumes an extremely important role in regulatio...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
SWI/SNF Complex Gene Mutations Promote the Liver Metastasis
of Non-small Cell Lung Cancer Cells in NSI Mice
Conclusion This study underscores the critical role of the GAs of SWI/SNF complex, such as ARID1A and SMARCA4, in promoting liver metastasis of lung cancer cells. The GAs of SWI/SNF complex may promote liver-specific metastasis by upregulating ALDH1A1 and APOBEC3B expression, providing novel insights into the molecular mechanisms underlying lung cancer liver metastasis.
DOI: 10.3779/j.issn.1009-3419.2023.102.35 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Mechanism Research of lncRNA miR143HG on Regulating the Biological Behavior
of Lung Squamous Cell Carcinoma H520 Cells
Background and objective There is a high morbidity, mortality, and poor clinical prognosis of lung squamous cell carcinoma (LUSC). However, there is currently no effective targeted treatment plan for LUSC. As a long non-coding RNA (lncRNA), lncRNA miR143HG has been proven to play an important role in the occurrence and development of various tumors. However, the biological role played by lncRNA miR143HG in LUSC cells is still unclear. Therefore, this study aimed to investigate the mechanism of lncRNA miR143HG on regulating the biological behavior of LUSC H520 cells. Methods Pan-cancer analysis and differential expression a...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Leptin-mediated ERK Signaling Pathway Promotes the Transformation
of Rat Alveolar Type II Epithelial Cells Induced by Yunnan Tin Mine Dust
This study aims to investigate the involvement of leptin-mediated extracellular regulated protein kinase (ERK) signaling pathway in the malignant transformation of rat alveolar type II epithelial cells induced by Yunnan tin mine dust. Methods Immortalized rat alveolar cells type II (RLE-6TN) cells were infected with Yunnan tin mine dust at a concentration of 200 μg/mL for nine consecutive generations to establish the infected cell model, which was named R200 cells. The cells were cultured normally, named as R cells. The expression of leptin receptor in both cell groups was detected using the Western blot method. The optim...
Source: Chinese Journal of Lung Cancer - October 20, 2023 Category: Cancer & Oncology Source Type: research
Radix Tetrastigme Polysaccharide Promotes Antitumor Immune Response
in Lewis Lung Cancer Mice
Conclusion Radix tetrastigme polysaccharide can inhibit tumor growth, metastasis and immune response in Lewis lung cancer mice, and its mechanism may be related to inhibiting SIRP/CD47 signaling pathway.
DOI: 10.3779/j.issn.1009-3419.2023.106.16 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 27, 2023 Category: Cancer & Oncology Source Type: research
Immune Thrombocytopenia Induced by Sintilimab in Lung Cancer:
A Case Report and Literature Review
We report one case of thrombocytopenia induced by ICIs and review the literature on thrombocytopenia associated with ICIs and discuss the clinical features, possible mechanisms, and optimal treatment.
DOI: 10.3779/j.issn.1009-3419.2023.102.32 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Immune Checkpoint Inhibitors Related Cystoureteritis:
A Case Report and Literature Review
A patient with advanced lung adenocarcinoma developed symptoms of frequent urination and urgent urination after 14 cycles of Pembrolizumab combined with chemotherapy. After making comprehensive analysis of the results of urine routine test, renal function, cystoscope and computed tomography (CT) examination, immune checkpoint inhibitors related cystoureteritis and acute kidney injury were considered. The patient ’s symptoms were relieved after discontinuation of Pembrolizumab combined with chemotherapy. However, the symptoms of urinary irritation worsened significantly after rechallenging Pembrolizumab combined with chem...
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
Research Advances of RAD51AP1 in Tumor Progression and Drug Resistance
The genomic instability may lead to an initiation of cancer in many organisms. Homologous recombination repair (HRR) is vital in maintaining cellular genomic stability. RAD51 associated protein 1 (RAD51AP1), which plays a crucial role in HRR and primarily participates in forming D-loop, was reported as an essential protein for maintaining cellular genomic stability. However, recent studies showed that RAD51AP1 was significantly overexpressed in various cancer types and correlated with poor prognosis. These results suggested that RAD51AP1 may play a significant pro-cancer effect in multiple cancers. The underlying mechanism...
Source: Chinese Journal of Lung Cancer - September 20, 2023 Category: Cancer & Oncology Source Type: research
