Comprehensive Analysis of the Relationship between m6A Methylation Patterns and Immune Microenvironment in Lung Adenocarcinoma
Conclusion m6A modification patterns play non-negligible roles in regulating the immune microenvironment. LRPPRC has potential to be a new biomarker for checkpoint inhibitor immunotherapy. 
 DOI: 10.3779/j.issn.1009-3419.2022.103.02 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - May 19, 2022 Category: Cancer & Oncology Source Type: research
Expert Consensus on the Treatment of Antiangiogenic Agents for Radiation Brain Necrosis
Vascular damage is followed by vascular endothelial growth factor (VEGF) expression at high levels, which is an important mechanism for cerebral radiation necrosis (CRN) development. Antiangiogenic agents (Bevacizumab) alleviates brain edema symptoms caused by CRN through inhibiting VEGF and acting on vascular tissue around the brain necrosis area. Many studies have confirmed that Bevacizumab effectively relieves symptoms caused by brain necrosis, improves patients ’ performance status and brain necrosis imaging. Considering that the efficacy of antiangiogenic therapy is mainly related to the duration of drug action, low...
Source: Chinese Journal of Lung Cancer - May 19, 2022 Category: Cancer & Oncology Source Type: research
Comparative Study of PD-L1 Expression in Different Sites of 
Non-small Cell Lung Cancer
This study aims to explore the differences of PD-L1 expression in test samples obtaining from different sites of NSCLC. This study may contribute to the detection strategy of PD-L1 in patients with advanced lung cancer. Methods One hundred and thirty-one cases of consecutively detected PD-L1 (22c3 assay, Dako) staining in metastatic NSCLC and 972 cases of non-paired intrapulmonary NSCLC were collected. The discrepancies of tumor proportion score (TPS) of PD-L1 expression in intrapulmonary samples and extrapulmonary metastatic samples of different sites were compared. Results The positive expression rate of PD-L1 in extrapu...
Source: Chinese Journal of Lung Cancer - May 16, 2022 Category: Cancer & Oncology Source Type: research
An Overview and Interpretation of Important Clinical Studies 
on Non-small Cell Lung Cancer in 2021
Though the coronavirus disease is still raging in 2021, clinical research on non-small cell lung cancer (NSCLC) did not stop. However, benefiting from advances in lung cancer treatment modality, NSCLC patients have experienced significant improvements in overall survival and quality of life. Currently, research advances on targeted therapy and immunotherapy have together transformed the status of postoperative adjuvant therapy and established a new standard treatment modality for resectable NSCLC. There are equally important research advances in locally advanced and advanced NSCLC, including new treatment modalities, new t...
Source: Chinese Journal of Lung Cancer - May 16, 2022 Category: Cancer & Oncology Source Type: research
Chinese Experts Consensus on Artificial Intelligence Assisted Management for 
Pulmonary Nodule (2022 Version)
Low-dose computed tomography (CT) for lung cancer screening has been proven to reduce lung cancer deaths in the screening group compared with the control group. The increasing number of pulmonary nodules being detected by CT scans significantly increase the workload of the radiologists for scan interpretation. Artificial intelligence (AI) has the potential to increase the efficiency of pulmonary nodule discrimination and has been tested in preliminary studies for nodule management. As more and more artificial AI products are commercialized, the consensus statement has been organized in a collaborative effort by Thoracic Su...
Source: Chinese Journal of Lung Cancer - April 26, 2022 Category: Cancer & Oncology Source Type: research
Two Case Reports of Type 2 Diabetes Induced by Immune Checkpoint Inhibitors 
Combined with Chemotherapy
This article reports two cases of type 2 diabetes mellitus induced by immune checkpoint inhibitor combined with chemotherapy, one of whom converted to type 1 diabetes mellitus, in order to increase the understanding of immunotherapy-related diabetes. 
 DOI: 10.3779/j.issn.1009-3419.2022.102.10 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Anti-angiogenesis in Lung Cancer: Current Situation, Progress and Confusion
Lung cancer is a highly vascular tumors, over the past ten years, anti-angiogenes is has been proved to be an effective and highly promising combinational treatment. The data of the combination of anti-angiogenesis with chemotherapy, targeted therapy, immunotherapy has been constantly updating. Advanced lung cancer patients, no matter different groups or different stages of the disease, are benefited from anti-angiogenes. In this paper, based on the clinical status and unsolved problems, combined with the latest clinical and translational research data, we reviewed the current anti-angiogenesis treatment of lung cancer. â€...
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Pneumocystis jirovecii Pneumonia in Patients with Lung Cancer: A Review
In recent years, with the widespread use of immunodepressant agents, Pneumocystis jirovecii pneumonia (PJP) has been significantly found in non-human immunodeficiency virus (HIV) patients, such as those with malignancies, post-transplantation and autoimmune diseases. Although the risk factors and management of PJP have been extensively studied in the hematologic tumor and post-transplant populations, the research on real tumor cases is insufficient. Lung cancer has been the most common tumor with the highest number of incidence and death worldwide, and the prognosis of lung cancer patients infected with PJP is poor in clin...
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Current Status and Progress of Thermal Ablation Combined with Immunotherapy for Lung Tumors
Recent studies have shown that tumor immune microenvironment is closely related to tumor progression, metastasis, recurrence and response to treatment. Some immunotherapies also offer hope for cancer patients. However, the efficacy of tumor immunotherapy is uncertain and has some side effects. In order to enhance its efficacy, tumor immunotherapy combined with tumor thermal ablation has been studied. Thermal ablation has the advantages of minimally invasive, rapid recovery, safety, fewer complications, conformation, reliable effect, repeatable, low cost, and has become the fourth tumor treatment measure after surgery, radi...
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Advances in Immunotherapy for Malignant Pleural Mesothelioma
This article will focus on the most up-to-date progress of MPM epidemiology, histological characteristics, pathogenesis, treatment patterns and the advances of immunotherapy in the disease. 
 DOI: 10.3779/j.issn.1009-3419.2022.101.17 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Single-versus Two-port Video-assisted Thoracic Surgery in Thymoma: 
A Propensity-matched Study
Conclusion SP-VATS in thymoma is a safe, feasible, and less invasive procedure, with less postoperative pain and faster recovery than multi-port VATS. 
 DOI: 10.3779/j.issn.1009-3419.2022.101.15 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Clinical Study of Artificial Intelligence-assisted Diagnosis System in Predicting the 
Invasive Subtypes of Early-stage Lung Adenocarcinoma Appearing as Pulmonary Nodules
Background and objective Lung cancer is the cancer with the highest mortality at home and abroad at present. The detection of lung nodules is a key step to reducing the mortality of lung cancer. Artificial intelligence-assisted diagnosis system presents as the state of the art in the area of nodule detection, differentiation between benign and malignant and diagnosis of invasive subtypes, however, a validation with clinical data is necessary for further application. Therefore, the aim of this study is to evaluate the effectiveness of artificial intelligence-assisted diagnosis system in predicting the invasive subtypes of e...
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Clinical Characteristics and Risk Factors Analysis for Visceral Pleural Invasion in 
Mixed Ground-glass Nodular Lung Adenocarcinoma
Background and objective Lung cancer is still the malignant tumor with the highest morbidity and mortality in China. Lung adenocarcinoma is the most common subtype, and the number of lung cancer presenting as mixed ground glass nodule (mGGN) in imaging is gradually increasing. Visceral pleural invasion (VPI) is an important factor affecting the prognosis of mGGN type lung adenocarcinoma. The aim of the study is to explore and analyze the risk factors for VPI in mGGN type lung adenocarcinoma. Methods From November 2016 to November 2019, 128 patients with mGGN lung adenocarcinoma underwent radical surgical resection in the F...
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
LINC00668 is Highly Expressed in Lung Squamous Cell Carcinoma and 
Promotes Tumor Cell Migration and Invasion
Conclusion LINC00668 might closely relate to the development of LUSC, and inhibition of LINC00668 may reduce the metastasis of LUSC. 
 DOI: 10.3779/j.issn.1009-3419.2022.102.05 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - April 20, 2022 Category: Cancer & Oncology Source Type: research
Characteristics and Clinical Implication of UGT1A1 Heterozygous Mutation in Tumor
Background: The literature recommends that reduced dosage of CPT-11 should be applied in patients with UGT1A1 homozygous mutations, but the impact of UGT1A1 heterozygous mutations on the adverse reactions of CPT-11 is still not fully clear. 
Methods: A total of 107 patients with UGT1A1 heterozygous mutation or wild-type, who were treated with CPT-11 from January 2018 to September 2021 in Peking University Third Hospital, were retrospectively enrolled. The adverse reaction spectra of patients with UGT1A1*6 and UGT1A1*28 mutations were analyzed. Adverse reactions were evaluated according to National Cancer Institute Common...
Source: Chinese Journal of Lung Cancer - March 25, 2022 Category: Cancer & Oncology Source Type: research
