Neutropenic Fever in Lung Cancer: Clinical Aspects Related to Mortality and Antibiotic Failure
Conclusions: Lower PS, severe anemia, and infections by Gram-negative or multi-resistant agents seem to be associated with worse outcomes in FN patients. DOI: 10.3779/j.issn.1009-3419.2021.102.36 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2021 Category: Cancer & Oncology Source Type: research
Feasibility Investigation of Fluorescence Method in Uniport Thoracoscopic Anatomical Segmentectomy for Identifying the Intersegmental Boundary Line
This study aimed to investigate the perioperative outcomes of patients who underwent uniport video-assisted thoracoscopic surgery (VATS) segmentectomy for identifying the intersegmental boundary line (IBL) by the near-infrared fluorescence imaging with intravenous indocyanine green (ICG) method or the modified inflation-deflation (MID) method and assess the feasibility and effectiveness of the ICG fluorescence (ICGF)-based method. Methods We retrospectively analyzed the perioperative data in total 198 consecutive patients who underwent uniport VATS segmentectomy between February 2018 and August 2020. With the guidance of p...
Source: Chinese Journal of Lung Cancer - November 19, 2021 Category: Cancer & Oncology Source Type: research
The Earliest Stage of Lung Adenocarcinoma:
the Pathological Diagnosis and Clinical Significance of Adenocarcinoma In Situ
This article will briefly explain the origin of the diagnosis of lung adenocarcinoma in situ, the adjustment of the new classification catalog, and whether adenocarcinoma in situ is benign or malignant.
DOI: 10.3779/j.issn.1009-3419.2021.102.35 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - November 19, 2021 Category: Cancer & Oncology Source Type: research
Expert Consensus on Tumor Mutational Burden for Immunotherapy in Lung Cancer
Lung cancer is one of the malignant tumors with the highest morbidity and mortality in the world. Immune checkpoint inhibitors (ICIs), including programmed cell death 1 (PD-1) antibody, programmed cell death ligand 1 (PD-L1) antibody, and cytotoxic T lymphocyte associated protein 4 (CTLA-4) antibody. It has brought significant survival benefits to some patients with advanced lung cancer and changed the treatment pattern of advanced lung cancer. Previous studies have shown that the objective response rate of PD-1/PD-L1 antibody in advanced non-small cell lung cancer (NSCLC) is only about 20%. So reliable biomarkers are urge...
Source: Chinese Journal of Lung Cancer - November 19, 2021 Category: Cancer & Oncology Source Type: research
Radiofrequency Ablation for Lung Ground-glass Nodule
Conclusion RFA is a safe, effective and minimally invasive technique for the treatment of lung GGNs.
DOI: 10.3779/j.issn.1009-3419.2021.101.35 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 26, 2021 Category: Cancer & Oncology Source Type: research
Response of Lung Adenocarcinoma Harbouring Sensitizing EGFR Mutation
to the Fourth-line Combination Treatment of Pembrolizumab and Anlotinib
45.7% of Chinese patients with advanced lung adenocarcinoma were reported to harbour sensitizing epidermal growth factor receptor (EGFR) mutations. Limited therapeutic options are left for non-small cell lung cancer (NSCLC) harbouring sensitizing EGFR mutations after failure of EGFR-tyrosine kinase inhibitor (TKI) therapy and chemotherapy, finding effective options for them is an unmet clinic need. Herein we reported a case that till January 12, 2021, an 82-year-old female with sensitizing EGFR-mutant advanced lung adenocarcinoma received a surprising progression-free survival (PFS) benefit of over 21 months from the combi...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Advances in Molecular Typing of Small Cell Lung Cancer
Small cell lung cancer (SCLC) is a highly aggressive and fatal malignant tumor. It has the characteristics of complex etiology, low differentiation, high malignancy, fast growth, strong invasiveness, early metastasis and acquired drug resistance, resulting in poor prognosis. In recent years, with the gradual deepening understanding on the molecular mechanism of SCLC and multi-omics data, it is proposed that molecular typing can be carried out according to the differential expression of key transcription factors, including SCLC-A, SCLC-N, SCLC-P and SCLC-I subtypes. Molecular typing of SCLC and its clinical application will...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Research Advances on Transformation to Small Cell Lung Cancer
This article will review research advances on the clinical features, molecular mechanism and treatment options of translational SCLC.
DOI: 10.3779/j.issn.1009-3419.2021.101.28 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Advances in Clinical Application of Liquid Biopsy in Non-small Cell Lung Cancer
Lung cancer, with the highest incidence in China, is the leading cause of death in cancer patients. Of these, about 85% are patients with non-small cell lung cancer (NSCLC). Therefore, the diagnosis and treatment of patients with lung cancer have always been a top priority nowadays. Fluid biopsy has many advantages, such as safety, convenience, repeatability, low trauma and so on, which are not available in traditional invasive biopsy. In recent years, with the rapid progress of molecular biological detection technology, fluid biopsy, as a new technology, has become the focus of attention. What ’s more, it contributes to...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Current Advance in Targeted Treatment and Immunotherapy for BRAF-mutant
Advanced Non-small Cell Lung Cancer
This article reviewed the progress of immunological and targeted therapy for patients with BRAF-mutated NSCLC.
DOI: 10.3779/j.issn.1009-3419.2021.101.29 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Research Progress of Epigenetic Mechanism in Acquired Resistance of
Targeted Therapy in Non-small Cell Lung Cancer
Patients with oncogenic driver alterations of non-small cell lung cancer (NSCLC) can benefit from targeted therapy, but acquired resistance is inevitable ultimately. Epigenetic modifications, including DNA methylation, histone modifications, non-coding RNA-mediated regulate and chromatin remodeling, are important mechanisms of acquired resistance in targeted therapy of NSCLC. In recent years, studies have found that epigenetic modifications can effectively reverse drug resistance. Targeted therapy combined with epigenetic modifications may become a promising therapeutic strategy. Here, we review the progress of epigenetic ...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Research Progress of Circular RNAs in Tumor Immunotherapy
Tumor immunotherapy is a new therapy which developed in recent years, it has greatly changed the therapeutic schedules and brought new options for patients. However, not all patients can have obvious therapeutic effects after using immunotherapy. So selecting more suitable patients and raising immunotherapy effect are worthy to discuss. With the research of circular RNAs (circRNAs), circRNAs have been found that they not only play a significant role in the field of tumor markers, tumor progression and prognosis, but also can abnormally express in a variety of tumors and affect tumor immunity. Therefore, the circRNAs expres...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Comparison of Four-hook Needle and Memory Alloy Coil
in Localization of Pulmonary Nodules
Background and objective With the extensive development of minimally invasive surgery for pulmonary nodules, preoperative localization becomes more and more critical. There are some defects in traditional localization methods, so it is necessary to improve. The aim of this study was to compare and analyze the safety and effectiveness of two new methods, namely four-hook needle and memory alloy coil, in the localization of pulmonary nodules. Methods A retrospective analysis of 152 patients was performed. 76 cases were in four-hook needle group, and 76 cases were in memory alloy coil group. Pulmonary nodules were located bef...
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Preliminary Study of CT Three-dimensional Reconstruction
Combined with Ground Glass Nodules of Natural Lung Collapse
in Thoracoscopic Pulmonary Segmental Resection
Conclusion CT three-dimensional reconstruction combined with GGN localization of natural lung collapse during operation can shorten the time of searching for GGN during operation and guarantee the safety of the incision margin. It is a more economical and convenient localization method and makes pulmonary segment resection more accurate.
DOI: 10.3779/j.issn.1009-3419.2021.101.39 (Source: Chinese Journal of Lung Cancer)
Source: Chinese Journal of Lung Cancer - October 20, 2021 Category: Cancer & Oncology Source Type: research
Clinical Analysis of Docetaxel Combined with PD-1/PD-L1 Inhibitor in Second-line Treatment of Advanced Non-small Cell Lung Cancer
Background and objective Programmed cell death 1 or programmed cell death ligand 1 inhibitor (PD-1/PD-L1 inhibitor) and docetaxel, as the standard second-line treatments of advanced non-small cell lung cancer (NSCLC) patients, have limited effects. There are few studies on whether docetaxel combined with PD-1/PD-L1 inhibitor can increase the efficacy and make patients better benefit. The aim of this study is to evaluate the efficacy and safety of docetaxel combined with PD-1/PD-L1 inhibitor for the second-line treatment of stage IV NSCLC patients. Methods Stage IV NSCLC patients (n=118) who received treatment at Shandong C...
Source: Chinese Journal of Lung Cancer - September 28, 2021 Category: Cancer & Oncology Source Type: research
