Carcinoid Heart Disease: Pathophysiology, Pathology, Clinical Manifestations, and Management
Carcinoid heart disease (CHD) is a rare and potentially lethal manifestation of an advanced carcinoid (neuroendocrine) tumor. The pathophysiology of CHD is related to vasoactive substances secreted by the tumor, of which serotonin is most prominent in the pathophysiology of CHD. Serotonin stimulates fibroblast growth and fibrogenesis, which can lead to cardiac valvular fibrosis. CHD primarily affects right heart valves, causing tricuspid and pulmonic regurgitation and less frequently stenosis of these valves. Left heart valves are usually spared because vasoactive substances such as serotonin are enzymatically inactivated ...
Source: Cardiology - October 16, 2020 Category: Cardiology Source Type: research
Genetic Spectrum of Left Ventricular Non-Compaction in Paediatric Patients
Conclusion: We detected a low burden of contractile sarcomeric variants in LVNC patients presenting below the age of 18 years, with the major number of variants residing in non-contractile structural sarcomeric genes. The identification of the variants in ion-channel and related genes not previously associated with LVNC in paediatric patients requires further examination of their functional role.Cardiology (Source: Cardiology)
Source: Cardiology - October 13, 2020 Category: Cardiology Source Type: research
A Prospective Registry of Atrial Fibrillation Ablation with the Ablation Index Technology: Rationale and Study Design
This is a prospective multicenter registry of atrial fibrillation (AF) ablation with the Ablation Index (AI) technology, which has been introduced as a marker predicting ablation lesion depth. The index incorporates the main parameters of radiofrequency point-by-point ablation: power, contact force, and time of ablation. The AI is calculated for every operator depending on personal skills, and there are no strict indications on the range of the parameter considering its safety and efficacy during pulmonary vein isolation. The registry aims to evaluate AI values used in different centers by different operators and to evalua...
Source: Cardiology - October 9, 2020 Category: Cardiology Source Type: research
Coronary Collateral Microcirculation Reserve Becomes Vestigial with Aging
Conclusion: Aging causes CCMR decline in rats.Cardiology (Source: Cardiology)
Source: Cardiology - October 8, 2020 Category: Cardiology Source Type: research
Assessing the Validity of Echocardiographic Criteria for Left Ventricular Diastolic Dysfunction in Patients with Pulmonary Hypertension
Conclusion: Our study suggests E/average e ’ may be the only reliable tissue Doppler parameter of LV diastolic dysfunction in patients with PHT, and that septal e’ is paradoxically decreased in patients with PHT and normal left-sided filling pressures.Cardiology (Source: Cardiology)
Source: Cardiology - October 8, 2020 Category: Cardiology Source Type: research
Plasma Somatostatin in Advanced Heart Failure: Association with Cardiac Filling Pressures and Outcome
Conclusions: Somatostatin concentrations were associated with CVP and CI in patients with HF. The pathophysiological mechanism may be related to congestion and/or hypoperfusion of the intestine. Somatostatin was an independent predictor of mortality in advanced HF.Cardiology (Source: Cardiology)
Source: Cardiology - October 7, 2020 Category: Cardiology Source Type: research
Interatrial Block Predicts Atrial Fibrillation and Total Mortality in Patients with Cardiac Resynchronization Therapy
Conclusions: IAB is associated with new-onset AF and death in CRT recipients and may be helpful in the risk stratification in the context of heart failure management. Abnormal PTFV1 did not demonstrate any prognostic value.Cardiology (Source: Cardiology)
Source: Cardiology - October 6, 2020 Category: Cardiology Source Type: research
“Covidsubo”: Stress-Induced Cardiomyopathy by Novel Coronavirus Disease 2019
Conclusion: Physicians and scientists around the globe should be aware of the psychological consequences of COVID-19 and their potential to cause physical illness.Cardiology (Source: Cardiology)
Source: Cardiology - September 28, 2020 Category: Cardiology Source Type: research
Impact of Preprocedural Aortic Valve Calcification on Conduction Disturbances after Transfemoral Aortic Valve Replacement
Conclusion: Orthogonal annular calcification confers an increased risk for conduction disturbances after TAVR. This is even more pronounced after implantation of balloon-expandable valves.Cardiology (Source: Cardiology)
Source: Cardiology - September 23, 2020 Category: Cardiology Source Type: research
Successful Transfemoral Transcatheter Aortic Valve Replacement in a Patient with Double Aortic Arch: An Interesting Imaging Case
We present the case of a patient incidentally found to have a right dominant double aortic arch who underwent successful TAVR for severe aortic stenosis.Cardiology (Source: Cardiology)
Source: Cardiology - September 21, 2020 Category: Cardiology Source Type: research
Vectorcardiography Findings Are Associated with Recurrent Ventricular Arrhythmias and Mortality in Patients with Heart Failure Treated with Implantable Cardioverter-Defibrillator Device
Conclusion: The spatial QRS-T angle and Twvm are emerging VCG indices which are independently associated with mortality in patients with reduced left ventricular ejection fraction due to ICMP or NICMP. Using a composite score of all 3 vector indices, a maximum score was associated with poor long-term survival.Cardiology (Source: Cardiology)
Source: Cardiology - September 21, 2020 Category: Cardiology Source Type: research
Height Is Associated with Dyslipidemia in Korean Premenopausal Women: Data from the Korea National Health and Nutrition Examination Survey
Conclusion: There was a dose-dependent correlation between adult height and adverse lipid profile in premenopausal Korean women who did not have CVD. This finding could serve as further evidence that dyslipidemia can be a link between shortness and CVD.Cardiology (Source: Cardiology)
Source: Cardiology - September 10, 2020 Category: Cardiology Source Type: research
Substantial Value of Cardiac Computed Tomography for the Evaluation of Patients with Suspected Prosthetic Valve Dysfunction
Cardiology (Source: Cardiology)
Source: Cardiology - September 8, 2020 Category: Cardiology Source Type: research
Cardioversion Safety – Are We Doing Enough?
There is a considerable periprocedural risk of thromboembolic events in atrial fibrillation patients undergoing cardioversion, and treatment with anticoagulants is therefore a hallmark of cardioversion safety. Based on retrospective subgroup analyses and prospective studies, non-vitamin K anticoagulants are at least as efficient as vitamin K-antagonists in preventing thromboembolic complications after cardioversion. The risk of thromboembolic complications after cardioversion very much depends on the comorbidities in a given patient, and especially heart failure, diabetes, and age #x3e;75 years carry a markedly increased r...
Source: Cardiology - September 8, 2020 Category: Cardiology Source Type: research
Prognostic Value of Biomarkers in Cardiac Allograft Vasculopathy following Heart Transplantation: A Literature Review
Cardiac allograft vasculopathy (CAV), also known as cardiac transplant vasculopathy, is a major determinant of long-term survival among cardiac transplantation recipients. Histologically, CAV is featured by diffuse, concentric thickening of the vascular wall, and primarily affects large and small epicardial coronary arteries, intramyocardial arteries, and veins. Owing to graft denervation, CAV typically follows an insidious course, and patients may not experience classic angina symptoms but instead present with progressive heart failure or ventricular arrhythmias. Recent studies on biomarkers have furthered the knowledge c...
Source: Cardiology - September 4, 2020 Category: Cardiology Source Type: research
