Single nucleotide polymorphisms associated with prostate cancer progression: a systematic review
CONCLUSION: This article highlights the importance of SNPs as potential markers of PCa progression and their possible functional relationship with some genes relevant to its development and progression. However, most variants were identified only in cohorts from two countries; no additional studies reproduce these findings.PMID:38055319 | DOI:10.1080/07357907.2023.2291776 (Source: Cancer Investigation)
Source: Cancer Investigation - December 6, 2023 Category: Cancer & Oncology Authors: Daniel Felipe Mendivelso Gonz ález Santiago Andr és Sánchez Villalobos Andrea Estefan ía Ramos Wendy Johana Montero Ovalle Martha Luc ía Serrano López Source Type: research
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer
Cancer Invest. 2023 Nov 24:1-10. doi: 10.1080/07357907.2023.2288640. Online ahead of print.ABSTRACTThe aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving phosphatidylinositol-3-OH kinase (PIK3)/AKT/mammalian target of rapamycin (mTOR) signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with non-muscle invasive bladder cancer (NMIBC). Alterations of these pathways were observed in 89.5% and 100% of patients, respectively. Among them, BARD1 was more frequently altered in low/intermediate-risk cases, but PARP4 was more frequently af...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Serdar Celik Tekincan Aktas Ozde Gokbayrak Aylin Erol Kutsal Yorukoglu Batuhan Yilmaz Hilmi Sari Zekiye Altun Mehmet Ugur Mungan Ilhan Celebi Guven Aslan Safiye Aktas Source Type: research
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer
Cancer Invest. 2023 Nov 20:1-11. doi: 10.1080/07357907.2023.2283495. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in the pathogenesis of CRC. We performed a comparative analysis of the expression of selected miRNA genes and EMT markers in bioptic samples from patients (n = 45) with primary CRC or metastatic (m)CRC to the regional lymph node using reverse transcription-quantitative PCR and IHC staining. Results: Out of all miRNA analyzed, the miR-17...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Veronika Hanusova Petra Matouskova Monika Manethova Jiri Soukup Stanislav John Martin Zofka Hana Vo šmikova Lukas Krbal Emil Rudolf Source Type: research
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer
Cancer Invest. 2023 Nov 24:1-10. doi: 10.1080/07357907.2023.2288640. Online ahead of print.ABSTRACTThe aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving phosphatidylinositol-3-OH kinase (PIK3)/AKT/mammalian target of rapamycin (mTOR) signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with non-muscle invasive bladder cancer (NMIBC). Alterations of these pathways were observed in 89.5% and 100% of patients, respectively. Among them, BARD1 was more frequently altered in low/intermediate-risk cases, but PARP4 was more frequently af...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Serdar Celik Tekincan Aktas Ozde Gokbayrak Aylin Erol Kutsal Yorukoglu Batuhan Yilmaz Hilmi Sari Zekiye Altun Mehmet Ugur Mungan Ilhan Celebi Guven Aslan Safiye Aktas Source Type: research
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer
Cancer Invest. 2023 Nov 20:1-11. doi: 10.1080/07357907.2023.2283495. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in the pathogenesis of CRC. We performed a comparative analysis of the expression of selected miRNA genes and EMT markers in bioptic samples from patients (n = 45) with primary CRC or metastatic (m)CRC to the regional lymph node using reverse transcription-quantitative PCR and IHC staining. Results: Out of all miRNA analyzed, the miR-17...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Veronika Hanusova Petra Matouskova Monika Manethova Jiri Soukup Stanislav John Martin Zofka Hana Vo šmikova Lukas Krbal Emil Rudolf Source Type: research
Genomic Alterations of Signaling and DNA Damage Repair Pathways in Non-Muscle Invasive Bladder Cancer
Cancer Invest. 2023 Nov 24:1-10. doi: 10.1080/07357907.2023.2288640. Online ahead of print.ABSTRACTThe aim of the study was to demonstrate the most common genetic alterations and evaluate possible targets involving phosphatidylinositol-3-OH kinase (PIK3)/AKT/mammalian target of rapamycin (mTOR) signaling and DNA damage repair (DDR) pathways for personalized treatment in patients with non-muscle invasive bladder cancer (NMIBC). Alterations of these pathways were observed in 89.5% and 100% of patients, respectively. Among them, BARD1 was more frequently altered in low/intermediate-risk cases, but PARP4 was more frequently af...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Serdar Celik Tekincan Aktas Ozde Gokbayrak Aylin Erol Kutsal Yorukoglu Batuhan Yilmaz Hilmi Sari Zekiye Altun Mehmet Ugur Mungan Ilhan Celebi Guven Aslan Safiye Aktas Source Type: research
Comparative Analysis of miRNA and EMT Markers in Metastatic Colorectal Cancer
Cancer Invest. 2023 Nov 20:1-11. doi: 10.1080/07357907.2023.2283495. Online ahead of print.ABSTRACTColorectal cancer (CRC) is the fourth most commonly diagnosed malignant condition in the world. Micro RNAs (miRNAs) as well as epithelial to mesenchymal transition (EMT) play an important role in the pathogenesis of CRC. We performed a comparative analysis of the expression of selected miRNA genes and EMT markers in bioptic samples from patients (n = 45) with primary CRC or metastatic (m)CRC to the regional lymph node using reverse transcription-quantitative PCR and IHC staining. Results: Out of all miRNA analyzed, the miR-17...
Source: Cancer Investigation - November 24, 2023 Category: Cancer & Oncology Authors: Veronika Hanusova Petra Matouskova Monika Manethova Jiri Soukup Stanislav John Martin Zofka Hana Vo šmikova Lukas Krbal Emil Rudolf Source Type: research
