"Neoadjuvant therapy and axillary lymph node status in HER2-positive breast cancer"
Cancer Invest. 2023 Jul 18:1-11. doi: 10.1080/07357907.2023.2238312. Online ahead of print.ABSTRACTBased on an estimating model, the aim of our study was to evaluate the axillary lymph node involvement of patients with primary invasive early human epidermal growth factor receptor 2 (HER2)-positive breast cancer before receiving neoadjuvant therapy (NAT). Patients with primary surgery (n = 63) were compared with patients who had received NAT (combined chemo/HER2-targeted antibody therapy) before surgery (n = 152). In patients receiving NAT, a positive N stage was estimated in 73.2 (49.8%) tumors resulting in a conversion (p...
Source: Cancer Investigation - July 18, 2023 Category: Cancer & Oncology Authors: Sabine Danzinger Christian Pfeifer Sophia Wimmer Kristina Tendl-Schulz Christian F Singer Source Type: research
The impact of Cancer-Associated Fibroblasts on drug resistance, stemness, and epithelial-mesenchymal transition in Bladder Cancer: A comparison between recurrent and non-recurrent patient-derived CAFs
This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered cell cycle distribution alongside induced resistance to apoptosis. Later, the scratch assay confirmed the cell migration-inducing effects of CAFs on cells. Nonetheless, only CAFs-R managed to increase sphere-formation and clonogenic levels in EJ138 cells, which were later validated by upregulating pluripotency transcription factors. Besides, CAFs-R also affected the expressi...
Source: Cancer Investigation - July 18, 2023 Category: Cancer & Oncology Authors: Nima Rastegar-Pouyani Vahideh Montazeri Nikoo Marandi Shima Aliebrahimi Melika Andalib Emad Jafarzadeh Hamed Montazeri Seyed Nasser Ostad Source Type: research
"Neoadjuvant therapy and axillary lymph node status in HER2-positive breast cancer"
Cancer Invest. 2023 Jul 18:1-11. doi: 10.1080/07357907.2023.2238312. Online ahead of print.ABSTRACTBased on an estimating model, the aim of our study was to evaluate the axillary lymph node involvement of patients with primary invasive early human epidermal growth factor receptor 2 (HER2)-positive breast cancer before receiving neoadjuvant therapy (NAT). Patients with primary surgery (n = 63) were compared with patients who had received NAT (combined chemo/HER2-targeted antibody therapy) before surgery (n = 152). In patients receiving NAT, a positive N stage was estimated in 73.2 (49.8%) tumors resulting in a conversion (p...
Source: Cancer Investigation - July 18, 2023 Category: Cancer & Oncology Authors: Sabine Danzinger Christian Pfeifer Sophia Wimmer Kristina Tendl-Schulz Christian F Singer Source Type: research
The impact of Cancer-Associated Fibroblasts on drug resistance, stemness, and epithelial-mesenchymal transition in Bladder Cancer: A comparison between recurrent and non-recurrent patient-derived CAFs
This study comparatively evaluated the possible effects of recurrent and non-recurrent patient-derived Cancer-Associated Fibroblasts (CAFs-R and -NR) on the bladder cancer cell line, EJ138. Both groups of CAFs increased cisplatin resistance and altered cell cycle distribution alongside induced resistance to apoptosis. Later, the scratch assay confirmed the cell migration-inducing effects of CAFs on cells. Nonetheless, only CAFs-R managed to increase sphere-formation and clonogenic levels in EJ138 cells, which were later validated by upregulating pluripotency transcription factors. Besides, CAFs-R also affected the expressi...
Source: Cancer Investigation - July 18, 2023 Category: Cancer & Oncology Authors: Nima Rastegar-Pouyani Vahideh Montazeri Nikoo Marandi Shima Aliebrahimi Melika Andalib Emad Jafarzadeh Hamed Montazeri Seyed Nasser Ostad Source Type: research
The Presence of Lung Cancer Affects SARS-CoV-2 Vaccine Uptake and Attitude in Chinese Patients: A Clinical Cross-Sectional Investigation
In conclusion, low vaccine uptake rates in patients with lung cancer could be improved by increasing confidence in vaccine safety, particularly for those with negative beliefs. Appropriate guidance and individualized vaccination plans that meet the healthcare needs of patients with lung cancer were needed during the constantly evolving pandemic.PMID:37401814 | DOI:10.1080/07357907.2023.2233624 (Source: Cancer Investigation)
Source: Cancer Investigation - July 4, 2023 Category: Cancer & Oncology Authors: Chen Chen Ruili Pan Liyuan Dai Minjiang Chen Jing Zhao Wei Zhong Mengzhao Wang Hongsheng Liu Yan Xu Xiaohong Han Source Type: research
