< em > TTN < /em > Mutation in Endometrial Endometrioid Carcinoma Is Associated with Poor Clinical Outcomes and High Tumor Mutation Burden
In conclusion, TTN mutation may serve as a biomarker for EEC prognosis. TTN mutation is also associated with WES-TMB, and could be a simplified TMB measurement technique.PMID:38666471 | DOI:10.1080/07357907.2024.2334249 (Source: Cancer Investigation)
Source: Cancer Investigation - April 26, 2024 Category: Cancer & Oncology Authors: Lihong Li Pinli Yue Jiarun Zhu Luyuan Li Kaipeng Wang Guangwen Yuan Yan Song Source Type: research
Radiation Oncologists' Views on Adjuvant Radiotherapy for Early-Stage Breast Cancer in the Elderly: Comparisons between Japan and the United States
CONCLUSIONS: Differences were observed on radiotherapy for older early-stage breast cancer.PMID:38666473 | DOI:10.1080/07357907.2024.2343860 (Source: Cancer Investigation)
Source: Cancer Investigation - April 26, 2024 Category: Cancer & Oncology Authors: Yoshiki Kuwatsuru Anneyuko I Saito Keisuke Usui Source Type: research
Comprehensive Analysis of N6-Methylandenosine-Related lncRNAs in Clear Cell Renal Cell Carcinoma: A Correlation With Prognosis, Tumor Progression, and Therapeutic Response
This study aims to develop a prognostic signature based on m6A-related lncRNAs for clear cell renal cell carcinoma (ccRCC). Differential expression analysis and Pearson correlation analysis were used to identify m6A-related lncRNAs associated with patient outcomes in The Cancer Genome Atlas (TCGA) database. Our approach led to the development of an m6A-related lncRNA risk score (MRLrisk), formulated using six identified lncRNAs: NFE4, AL008729.2, AL139123.1, LINC02154, AC124854.1 and ARHGAP31-AS1. Higher MRLrisk was identified as a risk factor for patients' prognosis in ccRCC. Furthermore, an MRLrisk-based nomogram was dev...
Source: Cancer Investigation - April 22, 2024 Category: Cancer & Oncology Authors: Chang Meng Juan Li Xiang Wang Yicen Ying Zhihua Li Aixiang Wang Xuesong Li Source Type: research
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340577. Online ahead of print.ABSTRACTChronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflammatory response and prognosis in patients with PDAC. We conducted the whole transcriptomic sequencing using tissue samples collected from patients diagnosed with PDAC (n = 106) recruited from Shandong Cancer Hospital. We first constructed a prognostic signature using 15 inflammation-related ge...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Xiaofeng Sun Hao Song Xiaoran Sun Chunhua Liao Guoqiang Wang Yu Xu Leo Li Yusheng Han Chunwei Xu Wenxian Wang Shangli Cai Hua Liang Hao Yu Source Type: research
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340576. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify consistently differentially expressed genes. A Venn analysis followed by gene network interactions revealed 23 key genes, from which we built a prognostic model using the COX algorithm (p = 0.000245, 3-year AUC = 0.967). This model stratifies patients into risk groups, with high-risk individuals showing worse outcomes and lower chem...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Pu Wang Yu Liu Lingyu Wei Jia Wang Jinsheng Wang Bin Du Source Type: research
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340577. Online ahead of print.ABSTRACTChronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflammatory response and prognosis in patients with PDAC. We conducted the whole transcriptomic sequencing using tissue samples collected from patients diagnosed with PDAC (n = 106) recruited from Shandong Cancer Hospital. We first constructed a prognostic signature using 15 inflammation-related ge...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Xiaofeng Sun Hao Song Xiaoran Sun Chunhua Liao Guoqiang Wang Yu Xu Leo Li Yusheng Han Chunwei Xu Wenxian Wang Shangli Cai Hua Liang Hao Yu Source Type: research
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340576. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify consistently differentially expressed genes. A Venn analysis followed by gene network interactions revealed 23 key genes, from which we built a prognostic model using the COX algorithm (p = 0.000245, 3-year AUC = 0.967). This model stratifies patients into risk groups, with high-risk individuals showing worse outcomes and lower chem...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Pu Wang Yu Liu Lingyu Wei Jia Wang Jinsheng Wang Bin Du Source Type: research
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340577. Online ahead of print.ABSTRACTChronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflammatory response and prognosis in patients with PDAC. We conducted the whole transcriptomic sequencing using tissue samples collected from patients diagnosed with PDAC (n = 106) recruited from Shandong Cancer Hospital. We first constructed a prognostic signature using 15 inflammation-related ge...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Xiaofeng Sun Hao Song Xiaoran Sun Chunhua Liao Guoqiang Wang Yu Xu Leo Li Yusheng Han Chunwei Xu Wenxian Wang Shangli Cai Hua Liang Hao Yu Source Type: research
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340576. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify consistently differentially expressed genes. A Venn analysis followed by gene network interactions revealed 23 key genes, from which we built a prognostic model using the COX algorithm (p = 0.000245, 3-year AUC = 0.967). This model stratifies patients into risk groups, with high-risk individuals showing worse outcomes and lower chem...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Pu Wang Yu Liu Lingyu Wei Jia Wang Jinsheng Wang Bin Du Source Type: research
A 15-Inflammation-Related Gene Signature Predicts the Prognosis of Patients With Pancreatic Ductal Adenocarcinoma
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340577. Online ahead of print.ABSTRACTChronic inflammation promotes the development of pancreatic ductal adenocarcinoma (PDAC) and PDAC-related inflammatory tumor microenvironment facilitates tumor growth and metastasis. Thus, we aimed to study the association between inflammatory response and prognosis in patients with PDAC. We conducted the whole transcriptomic sequencing using tissue samples collected from patients diagnosed with PDAC (n = 106) recruited from Shandong Cancer Hospital. We first constructed a prognostic signature using 15 inflammation-related ge...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Xiaofeng Sun Hao Song Xiaoran Sun Chunhua Liao Guoqiang Wang Yu Xu Leo Li Yusheng Han Chunwei Xu Wenxian Wang Shangli Cai Hua Liang Hao Yu Source Type: research
Development of a Novel Prognostic Model for Esophageal Squamous Cell Carcinoma: Insights into Immune Cell Interactions and Drug Sensitivity
Cancer Invest. 2024 Apr 14:1-17. doi: 10.1080/07357907.2024.2340576. Online ahead of print.ABSTRACTEsophageal squamous cell carcinoma (ESCC) presents a five-year survival rate below 20%, underscoring the need for improved prognostic markers. Our study analyzed ESCC-specific datasets to identify consistently differentially expressed genes. A Venn analysis followed by gene network interactions revealed 23 key genes, from which we built a prognostic model using the COX algorithm (p = 0.000245, 3-year AUC = 0.967). This model stratifies patients into risk groups, with high-risk individuals showing worse outcomes and lower chem...
Source: Cancer Investigation - April 14, 2024 Category: Cancer & Oncology Authors: Pu Wang Yu Liu Lingyu Wei Jia Wang Jinsheng Wang Bin Du Source Type: research
Veliparib ‑Induced Toxicity in Cancer Patients: A Systematic Review and Meta‑Analysis
In this study, we investigate the veliparib‑induced toxicity in cancer patients. Databases were searched for RCTs treated with veliparib. We found veliparib could increase the risk of hematologic and gastrointestinal toxicities. Anemia, neutropenia, thrombocytopenia, and nausea were the most common toxicities. Patients diagnosed with gastrointestinal tumors tend to have a higher risk of high-grade neutropenia; patients in the first-line setting tend to have a higher risk of high-grade anemia and neutropenia than those in the ≥ second line setting. Patients receiving higher dosage of veliparib tend to have a higher risk...
Source: Cancer Investigation - April 8, 2024 Category: Cancer & Oncology Authors: Peirong Wang Ruizhen Zhao Xiaohui Jin Xianhua Zhou Xiaolong Xie Source Type: research
