α-Gal antigen-deficient rabbits with GGTA1 gene disruption via CRISPR/Cas9
Previous studies have identified the carbohydrate epitope Gal α1–3Galβ1–4GlcNAc-R (termed the α-galactosyl epitope), known as the α-Gal antigen as the primary xenoantigen recognized by the human immune system. ... (Source: BMC Genetics)
Source: BMC Genetics - July 11, 2022 Category: Genetics & Stem Cells Authors: Lina Wei, Yufeng Mu, Jichao Deng, Yong Wu, Ying Qiao, Kun Zhang, Xuewen Wang, Wenpeng Huang, Anliang Shao, Liang Chen, Yang Zhang, Zhanjun Li, Liangxue Lai, Shuxin Qu and Liming Xu Tags: Research Source Type: research
A detailed workflow to develop QIIME2-formatted reference databases for taxonomic analysis of DNA metabarcoding data
The DNA metabarcoding approach has become one of the most used techniques to study the taxa composition of various sample types. To deal with the high amount of data generated by the high-throughput sequencing... (Source: BMC Genetics)
Source: BMC Genetics - July 8, 2022 Category: Genetics & Stem Cells Authors: Benjamin Dubois, Fr édéric Debode, Louis Hautier, Julie Hulin, Gilles San Martin, Alain Delvaux, Eric Janssen and Dominique Mingeot Tags: Research Source Type: research
Network-based inference of master regulators in epithelial membrane protein 2-treated human RPE cells
The application of cell-specific construction of transcription regulatory networks (TRNs) to identify their master regulators (MRs) in EMP2 induced vascular proliferation disorders has been largely unexplored. (Source: BMC Genetics)
Source: BMC Genetics - July 7, 2022 Category: Genetics & Stem Cells Authors: Hua Wan, Wei Gao, Wei Zhang, Zijiao Tao, Xiang Lu, Feng Chen and Jian Qin Tags: Research Source Type: research
Identification and genetic characterization of a minor norovirus genotype, GIX.1[GII.P15], from China
Human noroviruses, single-stranded RNA viruses in the family Caliciviridae, are a leading cause of nonbacterial acute gastroenteritis in people of all ages worldwide. Despite three decades of genomic sequencing a... (Source: BMC Genetics)
Source: BMC Genetics - July 6, 2022 Category: Genetics & Stem Cells Authors: Yanli Chen, Qiongwen Wu, Guiman Li, Hongzhe Li, Wenlong Li, Heng Li, Li Qin, Huiwen Zheng, Changkun Liu, Min Hou and Longding Liu Tags: Research Source Type: research
Identification of prognostic stemness biomarkers in colon adenocarcinoma drug resistance
Colon adenocarcinoma (COAD) is one of the leading causes of death worldwide. Cancer stem cells (CSCs) are vital for COAD chemoresistance and recurrence, however little is known about stem cell-related biomarke... (Source: BMC Genetics)
Source: BMC Genetics - July 6, 2022 Category: Genetics & Stem Cells Authors: Ziyue Li, Jierong Chen, Dandan Zhu, Xiaoxiao Wang, Jace Chen, Yu Zhang, Qizhou Lian and Bing Gu Tags: Research Source Type: research
Impact of 5HydroxyMethylCytosine (5hmC) on reverse/direct association of cell-cycle, apoptosis, and extracellular matrix pathways in gastrointestinal cancers
Aberrant levels of 5-hydroxymethylcytosine (5-hmC) can lead to cancer progression. Identification of 5-hmC-related biological pathways in cancer studies can produce better understanding of gastrointestinal (GI... (Source: BMC Genetics)
Source: BMC Genetics - June 29, 2022 Category: Genetics & Stem Cells Authors: Sayyed Sajjad Moravveji, Samane Khoshbakht, Majid Mokhtari, Mahdieh Salimi, Hossein Lanjanian, Sajjad Nematzadeh, Mahsa Torkamanian-Afshar and Ali Masoudi-Nejad Tags: Research Source Type: research
Identification of hub genes and pathways in colitis-associated colon cancer by integrated bioinformatic analysis
Colitis-associated colon cancer (CAC) patients have a younger age of onset, more multiple lesions and invasive tumors than sporadic colon cancer patients. Early detection of CAC using endoscopy is challenging,... (Source: BMC Genetics)
Source: BMC Genetics - June 22, 2022 Category: Genetics & Stem Cells Authors: Yongming Huang, Xiaoyuan Zhang, PengWang, Yansen Li and Jie Yao Tags: Research Source Type: research
Mitochondrial DNA sequences and transcriptomic profiles for elucidating the genetic underpinnings of cisplatin responsiveness in oral squamous cell carcinoma
Functional genetic variation plays an important role in predicting patients ’ response to chemotherapeutic agents. A growing catalogue of mitochondrial DNA (mtDNA) alterations in various cancers point to their ... (Source: BMC Genetics)
Source: BMC Genetics - June 21, 2022 Category: Genetics & Stem Cells Authors: Amnani Aminuddin, Pei Yuen Ng and Eng Wee Chua Tags: Data note Source Type: research
Analysis of codon usage bias of WRKY transcription factors in Helianthus annuus
The phenomenon of codon usage bias is known to exist in many genomes and is mainly determined by mutation and selection. Codon usage bias analysis is a suitable strategy for identifying the principal evolution... (Source: BMC Genetics)
Source: BMC Genetics - June 20, 2022 Category: Genetics & Stem Cells Authors: Yue Gao, Yan Lu, Yang Song and Lan Jing Tags: Research Source Type: research
Parallel and private generalized suffix tree construction and query on genomic data
Several technological advancements and digitization of healthcare data have provided the scientific community with a large quantity of genomic data. Such datasets facilitated a deeper understanding of several ... (Source: BMC Genetics)
Source: BMC Genetics - June 17, 2022 Category: Genetics & Stem Cells Authors: Md Momin Al Aziz, Parimala Thulasiraman and Noman Mohammed Tags: Research Source Type: research
miRNA-mRNA analysis of sheep adrenal glands reveals the network regulating reproduction
The adrenal gland participates in the process of sheep reproduction. MicroRNAs (miRNAs), endogenous small noncoding RNAs, regulate gene expression at the posttranscriptional level. However, the miRNA-mRNA netw... (Source: BMC Genetics)
Source: BMC Genetics - June 17, 2022 Category: Genetics & Stem Cells Authors: Yulin Chen, Yufang Liu and Mingxing Chu Tags: Research Source Type: research
Developing a bioinformatics pipeline for comparative protein classification analysis
Protein classification is a task of paramount importance in various fields of biology. Despite the great momentum of modern implementation of protein classification, machine learning techniques such as Random ... (Source: BMC Genetics)
Source: BMC Genetics - June 6, 2022 Category: Genetics & Stem Cells Authors: Benedetta Pelosi Tags: Research Source Type: research
Antagonistic regulatory effects of a single cis-acting expression quantitative trait locus between transcription and translation of the MRPL43 gene
This study aims to examine ... (Source: BMC Genetics)
Source: BMC Genetics - June 4, 2022 Category: Genetics & Stem Cells Authors: Jooyeon Han and Chaeyoung Lee Tags: Research Source Type: research
Bio-informatic analysis of CRISPR protospacer adjacent motifs (PAMs) in T4 genome
The existence of protospacer adjacent motifs (PAMs) sequences in bacteriophage genome is critical for the recognition and function of the clustered regularly interspaced short palindromic repeats-Cas (CRISPR-C... (Source: BMC Genetics)
Source: BMC Genetics - June 2, 2022 Category: Genetics & Stem Cells Authors: Omar Rawashdeh, Rabeah Y. Rawashdeh, Temesgen Kebede, David Kapp and Anca Ralescu Tags: Research Source Type: research
TP53 and TP53-associated genes are correlated with the prognosis of paediatric neuroblastoma
The objectives of the study were to analyse datasets of 2477 paediatric ... (Source: BMC Genetics)
Source: BMC Genetics - June 2, 2022 Category: Genetics & Stem Cells Authors: Haiwei Wang, Xinrui Wang, Liangpu Xu and Ji Zhang Tags: Research Source Type: research
