Artificial Intelligence for Cataract Detection and Management
The rising popularity of artificial intelligence (AI) in ophthalmology is fuelled by the ever-increasing clinical “big data” that can be used for algorithm development. Cataract is one of the leading causes of visual impairment worldwide. However, compared with other major age-related eye diseases, such as diabetic retinopathy, age-related macular degeneration, and glaucoma, AI development in the domain of cataract is still relatively underexplored. In this regard, several previous studies explored algorithms for automated cataract assessment using either slit lamp of color fundus photographs. However, several other st...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Chloroquine and Hydroxychloroquine Retinal Toxicity Consideration in the Treatment of COVID-19
The proposed doses of chloroquine (CQ) and hydroxychloroquine (HCQ) for treatment of COVID-19 (1000 mg/day for 10 days, CQ; 800 mg first day then 400 mg/day for 5 days, HCQ) in many guidelines worldwide, are considerably higher than the maximum recommended daily safe doses of both agents (≤2.3 mg/kg/day, CQ; ≤5.0 mg/kg/day, HCQ) for development of retinal toxicity. Irreversible retinal damage can occur if the exposure to the safe doses is>5 years. It is not known whether exposure to high doses over a short period of time can also cause the damage. We recommend that before prescribing CQ or HCQ, history of ocu...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Artificial Intelligence in Ophthalmology: Evolutions in Asia
Artificial intelligence (AI) has been studied in ophthalmology since availability of digital information in ophthalmic care. The significant turning point was availability of commercial digital color fundus photography in the late 1990s, which caused digital screening for diabetic retinopathy (DR) to take off. Automated Retinal Disease Assessment software was then developed using machine learning to detect abnormal lesions in fundus to screen DR. The use of this version of AI had not been generalized because the specificity at 45% was not high enough, although the sensitivity reached 90%. The recent breakthrough in machine...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Perspectives Source Type: research

COVID-19: Special Precautions in Ophthalmic Practice and FAQs on Personal Protection and Mask Selection
The Coronavirus Disease 2019 (COVID-19), caused by severe acute respiratory coronavirus-2, was first reported in December 2019. The World Health Organization declared COVID-19 a pandemic on March 11, 2020 and as of April 17, 2020, 210 countries are affected with>2,000,000 infected and 140,000 deaths. The estimated case fatality rate is around 6.7%. We need to step up our infection control measures immediately or else it may be too late to contain or control the spread of COVID-19. In case of local outbreaks, the risk of infection to healthcare workers and patients is high. Ophthalmic practice carries some unique risks and ...
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Perspectives Source Type: research

Artificial Intelligence in Ophthalmology in 2020: A Technology on the Cusp for Translation and Implementation
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Editorial Source Type: research

COVID-19 Pandemic: Ways Forward
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - March 1, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Utility and Feasibility of Teleophthalmology Using a Smartphone-Based Ophthalmic Camera in Screening Camps in Nepal
Conclusions: Remote ophthalmologist consultation utilizing a mobile device ophthalmic camera system is logistically feasible, easily scalable, and capable of capturing high-quality images in the setting of rural eye screening camps. Although OTs are well equipped to identify and triage anterior segment pathology, this technology may be helpful in the detection of and referral for posterior segment pathology. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Effects of Switching to Aflibercept in Treatment Resistant Macular Edema Secondary to Retinal Vein Occlusion
Purpose: The aim of this study was to examine 12-month outcomes of eyes switched from intravitreal ranibizumab or bevacizumab to aflibercept for cystoid macular edema due to retinal vein occlusion (RVO). Design: Retrospective, observation, case series. Methods: A retrospective study was performed assessing eyes with RVO switched to aflibercept for at least 12 months. To be included in the study, eyes had to have macular edema despite treatment for at least 6 months with bevacizumab and/or ranibizumab before the switch, central foveal thickness (CFT) ≥300 μm at time of switch, and visual acuity (VA) ≤60 early...
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Thyroid Eye Disease-Related Epiblepharon: A Comparative Case Study
This study describes the clinical features and management of epiblepharon as a manifestation of thyroid eye disease (TED). In addition, we compare the frequency and age in Asian and non-Asian patients, and discuss pathophysiologic implications. Design: Retrospective case-control study. Methods: This is a single-center retrospective review that identified 172 adult patients (age 19 to 83) with TED that were consecutively evaluated by 1 author (T.J.M.) between December 2015 and July 2018. Diagnosis of TED and epiblepharon was based upon clinical assessment as documented in the medical record. Results: In a cohort of...
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

A Novel Method of CT Exophthalmometry in Patients With Thyroid Eye Disease
Purpose: Conventional computed tomography (CT) exophthalmometry requires an intact lateral orbital wall and is therefore not feasible in patients who have undergone any form of lateral orbital wall surgery where the normal bony landmark may be lost or displaced. The purpose of our study is to validate an alternative method of CT exophthalmometry utilizing the posterior clinoid (PC) process as a new reference point that will allow for reproducible comparison of the anterior-posterior globe position in the preoperative and postoperative settings. Design: Cohort study. Methods: This is a retrospective study of 48 pati...
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Prophylactic Intravitreal Bevacizumab After Plaque Radiotherapy for Uveal Melanoma: Analysis of Visual Acuity, Tumor Response, and Radiation Complications in 1131 Eyes Based on Patient Age
Purpose: The aim of this study was to determine the impact of age on radiation complications after plaque radiotherapy and prophylactic intravitreal bevacizumab for uveal melanoma. Design: Retrospective cohort study. Methods: Retrospective single-center study of plaque-irradiated uveal melanoma with prophylactic intravitreal bevacizumab at 4-month intervals from July 2000 to January 2018. Results: Of 1131 eyes in 1131 patients, age was 70 years (n = 243). Comparison by age category (70 years) revealed the oldest group presenting with greatest tumor basal diameter (11.3 vs 11.3 vs 12.1 mm, P = 0.03) and...
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Acquired Ocular Motor Palsy: Current Demographic and Etiological Profile
Conclusions: Acquired cranial nerve palsy has younger onset in Indian scenario. Ischemia is the most common etiology raising concerns about the health issues of young Indians. Sixth nerve is most commonly involved in all age groups. Low recovery rate in fourth nerve palsy can be attributed to traumatic etiology. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Quantitative and Morphological Corneal Endothelial Changes After Selective Laser Trabeculoplasty and Retinal Photocoagulation
Conclusions: SLT has measurable effects on both quantitative and morphological characteristics of the corneal endothelium, which seem to be transient. RP has fewer measurable effects, likely because, although the total laser energy is similar, it is delivered over a much longer time (3 ns versus 0.1 s). The changes observed in both procedures are minor and unlikely to be of clinical significance. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Effect of Metabolic Syndrome on Blood Pressure Changes During Cataract Surgery
Conclusions: Well-controlled metabolic syndrome did not affect the changes in perioperative blood pressure during cataract surgery with topical anesthesia. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research

Aspergillus Endophthalmitis: Clinical Presentations and Factors Determining Outcomes
Conclusions: Early vitrectomy and intravitreal voriconazole yielded better anatomic and functional outcomes in Aspergillus endophthalmitis. Favorable visual outcome was achieved in a fifth of the eyes and globe was salvaged in two-thirds of the eyes. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - January 1, 2020 Category: Opthalmology Tags: Original Clinical Study Source Type: research