Wide-Field (15 × 9 mm) Swept-Source Optical Coherence Tomography Angiography Following Plaque Radiotherapy of Choroidal Melanoma: An Analysis of 105 eyes
Purpose: The aim of this study was to evaluate retinal microvascular abnormalities following plaque radiotherapy of choroidal melanoma (CM) using wide-field swept-source optical coherence tomography angiography (OCTA). Design: Single-centre retrospective review. Methods: Retrospective case series of 105 CM patients treated with I-125 plaque radiotherapy and imaged with wide-field (15 × 9 mm) SS-OCTA from March 2018 to August 2018 at the Ocular Oncology Service, Wills Eye Hospital (Philadelphia, PA). Results: At mean follow-up of 49 months (range 4–297) after plaque radiotherapy, there were 52 eyes (50%) w...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Original Study Source Type: research

Detecting Common Eye Diseases Using the First Teleophthalmology GlobeChek Kiosk in the United States: A Pilot Study
Conclusions: GlobeChek kiosk is both workable and effective in increasing access to care and identifying the most common causes of blindness and their risk factors. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Original Study Source Type: research

Smartphone-Based Fundus Imaging–Where Are We Now?
In conclusion, SBFI has the potential to make fundus examinations and screenings for patients particularly in low- and middle-income settings more accessible and, therefore, aid tackling the burden of diabetic retinopathy, glaucoma, and retinopathy of prematurity screening. However, image quality for SBFI varies substantially and a reference standard for grading appears prudent. In addition, there is a strong need for comparison of different SBFI approaches in terms of applicability to disease screening and cost-effectiveness. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Deployment of Artificial Intelligence in Real-World Practice: Opportunity and Challenge
The objective of this review is to summarize the opportunities and challenges of this transition and to facilitate the integration of artificial intelligence (AI) into routine clinical practice based on our best understanding and experience in this area. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Perspectives Source Type: research

Big Data in Ophthalmology
Big data is the fuel of mankind's fourth industrial revolution. Coupled with new technology such as artificial intelligence and deep learning, the potential of big data is poised to be harnessed to its maximal in years to come. In ophthalmology, given the data-intensive nature of this specialty, big data will similarly play an important role. Electronic medical records, administrative and health insurance databases, mega national biobanks, crowd source data from mobile applications and social media, and international epidemiology consortia are emerging forms of “big data” in ophthalmology. In this review, we discuss th...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Evolving Practice Patterns in Singapore's Public Sector Ophthalmology Centers During the COVID-19 Pandemic
This article discusses the measures put in place by the 3 largest ophthalmology centers in Singapore's public sector in response to COVID-19, and the challenges of providing eye care in the face of stringent infection control directives, staff redeployments and “social distancing.” The recently imposed “circuit breaker,” effectively a partial lockdown of the country, has further limited our work to only the most essential of services. Our staff are also increasingly part of frontline efforts in the screening and care of patients with COVID-19. However, this crisis has also been an opportunity to push ahead with inn...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Perspectives Source Type: research

COVID-19: Ocular Manifestations and the APAO Prevention Guidelines for Ophthalmic Practices
This article describes the ocular manifestations of COVID-19 and the APAO guidelines in mitigating the risks of contracting and/or spreading COVID-19 in ophthalmic practices. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Perspectives Source Type: research

Impact of COVID-19 on Ophthalmology and Future Practice of Medicine
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Translational Retinal Imaging
The diagnosis and treatment of medical retinal disease is now inseparable from retinal imaging in all its multimodal incarnations. The purpose of this article is to present a selection of very different retinal imaging techniques that are truly translational, in the sense that they are not only new, but can guide us to new understandings of disease processes or interventions that are not accessible by present methods. Quantitative autofluorescence imaging, now available for clinical investigation, has already fundamentally changed our understanding of the role of lipofuscin in age-related macular degeneration. Hyperspectra...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Latest Developments in Polypoidal Choroidal Vasculopathy: Epidemiology, Etiology, Diagnosis, and Treatment
Polypoidal choroidal vasculopathy (PCV) is a condition characterized by multiple, recurrent, serosanguineous pigment epithelial detachments, and neurosensory retinal detachments due to abnormal aneurysmal neovascular lesions. It is generally considered as a variant of neovascular age-related macular degeneration, but there are some differences between the clinical presentation, natural history, and treatment response between patients with PCV and typical neovascular age-related macular degeneration patients. Over the past decade, new research and technological advancements have greatly improved our understanding of the PCV...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Emerging Therapies in Neovascular Age-Related Macular Degeneration in 2020
Age-related macular degeneration (AMD) is one of the most common causes of vision loss. Advanced forms of AMD are seen in primarily 2 types—neovascular AMD (nAMD) with the presence of choroid neovascularization and nonneovascular AMD (nnAMD) with geographic atrophy. Although there are 4 anti-vascular endothelial growth factor drugs either widely used or approved for the former, there are no current treatments for the latter. This review will highlight upcoming treatments for AMD currently in clinical trials. For nAMD: Abicipar pegol, an intravitreal anti-vascular endothelial growth factor based on designed ankyrin repeat...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Chorioretinal Anastomosis for Central Retinal Vein Occlusion: A Review of Its Development, Technique, Complications, and Role in Management
This article reviews the preclinical and clinical development of the L-CRA and the results of the studies into its effect on the natural history of CRVO. It now can be used in combination with existing anti-VEGF treatments with the intravitreal agents addressing the component of the CRVO-induced macular edema due to the cytokine dysregulation, and the L-CRA addressing the component due to the elevated CVP and retinal venous stagnation. Improvements in laser technology have led to higher success rates in L-CRA creation and potential complications are now minimized and better controlled. The combination of L-CRA with intravi...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

High Myopia and Glaucoma-Like Optic Neuropathy
Conclusions: In highly myopic eyes, one should be vigilant not to overlook GON. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

A Review of Pharmacological Presbyopia Treatment
Presbyopia reduces an individual's ability to perform visual tasks at near distances. It is a global problem, affecting over a billion people worldwide. Contact lenses, glasses, refractive surgery, and intraocular lens surgery are the main modalities in presbyopia treatment, although they all have some disadvantages. Thus, there is an increasing need for effective, easy-to-use, and noninvasive approaches for treating presbyopia while not limiting patients’ daily activities. Pharmacological presbyopia treatment as an alternative method has been under investigation in recent years. We reviewed all relevant articles using t...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Ginkgo Biloba Extract in Ophthalmic and Systemic Disease, With a Focus on Normal-Tension Glaucoma
Glaucoma is a neurodegenerative eye disease that results in retinal ganglion cell loss and ultimately loss of vision. Elevated intraocular pressure (IOP) is the most common known risk factor for retinal ganglion cell damage and visual field loss, and the only modifiable risk factor proven to reduce the development and progression of glaucoma. This has greatly influenced our approach and assessment in terms of diagnosis and treatment. However, as many as ≥50% of patients with progressive vision loss from primary open angle glaucoma without IOP elevation (≤22 mm Hg) have been reported in the United States and Canada; 90%...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research