Asia-Pacific Journal of Ophthalmology This is an RSS file. You can use it to subscribe to this data in your favourite RSS reader or to display this data on your own website or blog.

Japan to Global Eye Genetics Consortium: Extending Research Collaboration for Inherited Eye Diseases
Japan Eye Genetics Consortium (JEGC) was established in 2011 to migrate research system to all-Japan structure for collecting phenotype-genotype information for inherited retinal diseases and other retinal diseases including hereditary optic neuropathy and hereditary glaucoma. Diagnostic team was assembled to maintain quality of diagnostic and to collect phenotype information to database in Tokyo Medical Center (TMC). Over the past 10 years, 1538 pedigree [2788 deoxyribonucleic acid (DNA) samples] was collected from 38 ophthalmology departments and eye hospitals. Whole exome analysis has improved diagnostic rate from ~17% ...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

New Frontier in the Management of Corneal Dystrophies: Basics, Development, and Challenges in Corneal Gene Therapy and Gene Editing
Abstract: Corneal dystrophies represent a group of heterogeneous hereditary disorders causing progressive corneal opacification and blindness. Current corneal transplant management for corneal dystrophies faces the challenges of repeated treatments, complex surgical procedures, shortage of appropriate donor cornea, and, more importantly, graft rejection. Genetic medicine could be an alternative treatment regime to overcome such challenges. Cornea carries promising scope for a gene-based therapy involving gene supplementation, gene silencing, and gene editing in both ex vivo and in vivo platforms. In the cornea, ex vivo...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

Current Advancements in Corneal Cell–Based Therapy
Corneal epithelial stem cells (CEpSCs) mostly reside at the limbal area and are responsible for tissue homeostasis throughout life. Once complete CEpSC deficiency occurs, regenerative medicine cell-based therapy using CEpSCs or their alternatives can provide successful clinical outcomes. Due to an improved understanding of CEpSCs and mucosal epithelial stem cells, major advancements have been made over the past few decades in in vivo and ex vivo cell-based ocular surface reconstruction therapies for the treatment of severe ocular surface diseases. New therapeutic concepts and clinical strategies are emerging for the treatm...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

Epigenetics and Degenerative Retinal Diseases: Prospects for New Therapeutic Approaches
Abstract: There is growing evidence that retinal degenerative diseases are accompanied by epigenetic changes in both deoxyribonucleic acid methylation and histone modification. Even in the monogenic disease retinitis pigmentosa, there is a cascade of changes in gene expression that correlate with epigenetic changes, suggesting that many of the symptoms, and degenerative changes, may be a result of epigenetic changes downstream from the genetic mutation. This is supported by data from studies of diabetic retinopathy and macular degeneration, 2 diseases where it has been difficult to define a single causative change. Ini...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

The Prospects for Retinal Organoids in Treatment of Retinal Diseases
In conclusion, methods to derive ROs from pluripotent stem cells have significantly improved and become more efficient in recent years. Meanwhile, more novel technologies are applied to characterize and validate RO quality. However, opportunity remains to optimize tissue differentiation protocols and achieve better RO reproducibility. In order to screen high-quality ROs for downstream applications, approaches such as noninvasive and label-free imaging and electrophysiological functional testing are promising and worth further investigation. Lastly, transplanted RO-derived tissues have allowed improvements in visual functio...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

New Prospects for Retinal Pigment Epithelium Transplantation
Abstract: Retinal pigment epithelium (RPE) transplants rescue photoreceptors in selected animal models of retinal degenerative disease. Early clinical studies of RPE transplants as treatment for age-related macular degeneration (AMD) included autologous and allogeneic transplants of RPE suspensions and RPE sheets for atrophic and neovascular complications of AMD. Subsequent studies explored autologous RPE–Bruch membrane–choroid transplants in patients with neovascular AMD with occasional marked visual benefit, which establishes a rationale for RPE transplants in late-stage AMD. More recent work has involved transpl...
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Review Articles Source Type: research

Regenerative Medicine, Advanced Stem Cell, and Gene Therapies for Eye Diseases
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - July 1, 2022 Category: Opthalmology Tags: Editorial Source Type: research

Choroidal Neovascularization: A Rare Complication of Sclerochoroidal Calcification
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Intriguing Images Source Type: research

Double Capsular Opacification
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Intriguing Images Source Type: research

Fluorescein Angiography Detection of Combined Branch Retinal Vein and Artery Occlusion
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Intriguing Images Source Type: research

Widefield Optical Coherence Tomography Angiography for Pregnancy-Associated Central Serous Chorioretinopathy
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Intriguing Images Source Type: research

Patients Perceptions of Artificial Intelligence in Diabetic Eye Screening
Conclusions: There is low awareness of clinical AI applications among our participants. Despite this, most are receptive toward the implementation of AI in diabetic eye screening. Overall, there was a strong preference toward continual involvement of clinicians in the screening process. There are key recommendations to enhance the receptivity of the public toward incorporation of AI into retinal screening programs. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Original Article Source Type: research

Longitudinal Change in Retinal Nerve Fiber Layer Thickness and Its Association With Central Retinal Sensitivity After Epiretinal Membrane Surgery
This study enrolled 82 eyes of 82 Japanese patients that underwent surgery for unilateral idiopathic ERM, with their fellow eyes as controls. pRNFL thickness was measured in 4 (superior, temporal, inferior, and nasal) quadrants preoperatively and at 1, 3, 6, and 12 months postoperatively. Microperimetry was performed at 12 months postoperatively to evaluate central retinal sensitivity. Regression tree analysis was performed to predict pRNFL thickness at 12 months postoperatively. Results: The temporal quadrant showed continuous pRNFL thinning after surgery, reaching statistical significance at 3, 6, and 12 m...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Clinical Findings of Specular Microscopy Images in Cytomegalovirus Corneal Endotheliitis
Conclusions: In CMV endotheliitis, owl's eye cells were observed by specular microscopy with high probability (82%). Corneal endothelial cells significantly decreased when owl's eye cells were observed by specular microscopy. Specular microscopy represents a useful noninvasive auxiliary tool for diagnosing and monitoring CMV corneal endotheliitis. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Original Study Source Type: research

Digital Education in Ophthalmology
Accessibility to the Internet and computer systems has prompted the gravitation towards digital learning in medicine, including ophthalmology. Using the PubMed database and Google search engine, current initiatives in ophthalmology that serve as alternatives to traditional in-person learning with the purpose of enhancing clinical and surgical training were reviewed. This includes the development of teleeducation modules, construction of libraries of clinical and surgical videos, conduction of didactics via video communication, and the implementation of simulators and intelligent tutoring systems into clinical and surgical ...
Source: Asia-Pacific Journal of Ophthalmology - May 1, 2022 Category: Opthalmology Tags: Review Article Source Type: research