Determining Progression in Ectatic Corneal Disease
Before the advent of modern tomographic imaging and corneal cross-linking (CXL), diagnosis and treatment of ectatic disease were limited to disease severity where changes on the anterior corneal surface lead to visual complaints. Rigid contact lenses and/or penetrating keratoplasty addressed late stage disease, as identifying early or subclinical disease was not possible, or its need appreciated. The emergence of CXL as a viable treatment to alter the natural progression of keratoconus heightened the need for improved diagnostics. Several methods have been described in the literature to evaluate and document progression...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Biochemical Markers and Alterations in Keratoconus
Keratoconus (KC) is a corneal ectatic condition characterized by focal structural changes, resulting in progressive thinning, biomechanical weakening, and steeping of the cornea that can lead to worsening visual acuity due to irregular astigmatism and corneal scarring in more advanced cases. It is a relatively common ectatic disease of the cornea predominantly affecting the younger population. Despite its worldwide prevalence, its incidence is rather varied with a higher incidence among the Middle Eastern and South Asian population. Dysregulated corneal extracellular matrix remodeling underlies KC pathogenesis. However, a ...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Therapeutic Contact Lenses in the Treatment of Corneal and Ocular Surface Diseases—A Review
Therapeutic contact lenses (TCLs) are often used in the management of a wide variety of corneal and ocular surface diseases (OSDs). Indications of TCL include pain relief, enhancing corneal healing, corneal sealing, corneal protection, and drug delivery. For painful corneal diseases such as bullous keratopathy, epidermolysis bullosa, and epithelial abrasions/erosions, bandage contact lenses (BCLs) provide symptomatic relief. Postoperatively in photorefractive keratectomy or laser epithelial keratomileusis, BCLs also alleviate pain. In severe OSDs such as severe dry eye, Stevens-Johnson syndrome/toxic epidermal necrolysis, ...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Surgical Management of Limbal Stem Cell Deficiency
Treatment of limbal stem cell deficiency is challenging. Multiple options can be adopted according to the underlying cause and the patient and physician preferences. Stem cell transplant is a common treatment modality and several techniques have been described with outcomes varying by the laterality of the condition. Keratoprosthesis is a preferred option for bilateral conditions. Indications for type 1 and type 2 keratoprosthesis differ and the past 2 decades have seen a revolution in the field of keratoprosthesis with encouraging and improved outcomes. Management also includes preventive measures and measures to optimize...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Ocular Surface Microbiome in Health and Disease
The ocular surface is exposed continuously to the environment and, as a consequence, to a variety of different microbes. After the results of the Human Microbiome Project became publicly available, international research groups started to focus interest on exploring the ocular surface microbiome and its physiopathological relationship to the eye. For example, numerous research studies the existence of the ocular surface's bacterial flora, typically gathering cultures from healthy patients and finding few variations in the bacterial species. More recently, culture-independent methods, including 16S ribosomal ribonucleic aci...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Contact Lens Wear and Dry Eye: Beyond the Known
Contact lens wear is one of the relevant risk factors for dry eye, and the coexistence of dry eye poses a serious challenge in patients wearing contact lenses. The Tear Film and Ocular Surface Society Workshop addressed issues around the topic of discomfort in contact lens wear, which is a major cause for discontinuation of contact lens wear, and termed this condition as contact lens discomfort. With the rapid advances in contact lens technology and pharmacological agents and deeper understanding of this field, updating the “new normal” beyond what is known as standard is essential. This review aims to summarize the la...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Digital Screen Use and Dry Eye: A Review
Prolonged and continuous daily use of digital screens, or visual display terminals (VDTs), has become the norm in occupational, educational, and recreational settings. An increased global dependence on VDTs has led to a rise in associated visual complaints, including eye strain, ocular dryness, burning, blurred vision, and irritation, to name a few. The principal causes for VDT-associated visual discomfort are abnormalities with oculomotor/vergence systems and dry eye (DE). This review focuses on the latter, as advances in research have identified symptomology and ocular surface parameters that are shared between prolonged...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Understanding the Dual Dilemma of Dry Eye and Glaucoma: An International Review
Glaucoma-related ocular surface disease (G-OSD) is a significant, yet often underdiagnosed, ocular co-morbidity affecting 40% to 59% of glaucoma patients worldwide. Although the use of topical glaucoma medications represents a proven strategy to control the untoward effects of high intraocular pressure, this treatment can profoundly disrupt the homeostasis of the tear film. The cumulative effect of medications, preservatives, and excipients alter underlying cellular structures which results in tear film abnormalities and instability of the ocular surface. Furthermore, these chronic inflammatory changes have been shown to i...
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

New Consideration for Old Conditions
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - November 1, 2020 Category: Opthalmology Tags: Editorial Source Type: research

Ophthalmology Practice in the UK
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Does Video Gaming Improve Ophthalmological Surgical Proficiency?
No abstract available (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Letters to the Editor Source Type: research

Functional Difficulties of Patients Seeking Low Vision Services in South India
This study was approved by the AECS Institutional Review Board and all participants provided informed consent. Results: The study included 419 participants (mean age 42.0 years, 65.2% male). Retinal dystrophy (35.8%) and acquired retinal disease (22.0%) were the most common diagnoses. The most frequently cited functional concerns were reading (37.7%), mobility (19.9%), and facial identification (13.8%). The number of functional concerns did not vary by diagnosis, age, sex, education, occupation, or presenting visual acuity (P> 0.05). Participants with retinal dystrophy were more likely to cite problems with night vision...
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Original Study Source Type: research

A Six-Year Review of the Latest Oculoplastic Surgical Development
Conclusions: The recent trend of periocular surgical rejuvenation focuses on preserving soft tissue volume, avoiding skin or use hidden incision, taking the eyebrow and midface position into account, and measures to minimize iatrogenic eyelid malposition. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Intraocular Tumors: Angiographic Patterns
Intraocular tumors are primarily diagnosed clinically. However, ancillary tests such as fluorescein angiogram provides excellent visualization of retinal tumors while indocyanine green angiography reveals intrinsic vascular patterns of choroidal tumors. In this review, we contrast angiographic patterns of a variety of retinal, choroidal, and iris tumors. (Source: Asia-Pacific Journal of Ophthalmology)
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research

Retinopathy of Prematurity: How to Prevent the Third Epidemics in Developing Countries
Retinopathy of prematurity (ROP) is vasoproliferative disease affecting preterm infants and is a leading cause of avoidable childhood blindness worldwide. The world is currently experiencing the third epidemic of ROP, where majority of the cases are from middle-income countries. Over 40% of the world's premature infants were born in India, China, Bangladesh, Pakistan, and Indonesia. Together with other neighboring nations, this region has unique challenges in ROP management. Key aspects of the challenges including heavier and more mature infants developing severe ROP. Current strategies include adoption of national screeni...
Source: Asia-Pacific Journal of Ophthalmology - September 1, 2020 Category: Opthalmology Tags: Review Article Source Type: research