Phylogenotyping of infectious bursal disease virus in Vietnam according to the newly unified genotypic classification scheme
AbstractSince 1987, infectious bursal disease virus (IBDV) has circulated and evolved in Vietnam, but little is known about the genotypes present. IBDV samples were collected in 1987, 2001-2006, 2008, 2011, 2015-2019, and 2021 in 18 provinces. We conducted phylogenotyping analysis based on an alignment of 143 VP2-HVR (hypervariable region) sequences from 64 Vietnamese isolates (26 previous and 38 additional sequences and two vaccines, and alignment of 82 VP1 B-marker sequences, including one vaccine and four Vietnamese field strains. The analysis identified three A-genotypes, A1, A3, and A7, and two B-genotypes, B1 and B3,...
Source: Archives of Virology - July 4, 2023 Category: Virology Source Type: research
The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus
This study highlights the protective effect of commercial attenuated live vaccines against the novel IBDV variant and provides guidance for the prevention and control of this disease. (Source: Archives of Virology)
Source: Archives of Virology - July 4, 2023 Category: Virology Source Type: research
Molecular characterization of a novel ambiguivirus isolated from the phytopathogenic fungus Setosphaeria turcica
In this study, a novel single-stranded RNA virus was isolated from the plant-pathogenic fungusSetosphaeria turcica strain TG2, and the virus was named"Setosphaeria turcica ambiguivirus 2" (StAV2). The complete nucleotide sequence of the StAV2 genome was determined using RT-PCR and RLM-RACE. The StAV2 genome comprises 3,000 nucleotides with a G+C content of 57.77%. StAV2 contains two in-frame open reading frames (ORFs) with the potential to produce an ORF1-ORF2 fusion protein via a stop codon readthrough mechanism. ORF1 encodes a hypothetical protein (HP) of unknown function. The ORF2-encoded protein shows a high ...
Source: Archives of Virology - July 4, 2023 Category: Virology Source Type: research
Phylogenotyping of infectious bursal disease virus in Vietnam according to the newly unified genotypic classification scheme
AbstractSince 1987, infectious bursal disease virus (IBDV) has circulated and evolved in Vietnam, but little is known about the genotypes present. IBDV samples were collected in 1987, 2001-2006, 2008, 2011, 2015-2019, and 2021 in 18 provinces. We conducted phylogenotyping analysis based on an alignment of 143 VP2-HVR (hypervariable region) sequences from 64 Vietnamese isolates (26 previous and 38 additional sequences and two vaccines, and alignment of 82 VP1 B-marker sequences, including one vaccine and four Vietnamese field strains. The analysis identified three A-genotypes, A1, A3, and A7, and two B-genotypes, B1 and B3,...
Source: Archives of Virology - July 4, 2023 Category: Virology Source Type: research
The attenuated live vaccine strain W2512 provides protection against novel variant infectious bursal disease virus
This study highlights the protective effect of commercial attenuated live vaccines against the novel IBDV variant and provides guidance for the prevention and control of this disease. (Source: Archives of Virology)
Source: Archives of Virology - July 4, 2023 Category: Virology Source Type: research
Molecular characterization of a novel umbra-like virus from Thuja orientalis (arborvitae) in South Korea
AbstractA novel umbra-like virus was identified in arborvitae in South Korea using RNA sequencing (RNA-seq). The virus identified was tentatively named"arborvitae umbra-like virus" (AULV) and contained a 4,300-nucleotide genome organized into four non-structural open reading frames (ORFs). Cloning and Sanger sequencing were used to confirm the viral contig sequence and determine the size of the genome. Genome analysis indicated that ORF2 encodes an RNA-dependent RNA polymerase that is probably expressed through ribosomal frameshifting. ORF3 encodes a putative long-distance movement protein, while the functions of...
Source: Archives of Virology - July 1, 2023 Category: Virology Source Type: research
A novel mitovirus isolated from the filamentous fungus Hypoxylon fendleri
In this study, a novel mycovirus, designated “Hypoxylon fendleri mitovirus 1” (HfMV1), was isolated from this fungus. The genome of HfMV1 is 2850 nt in length with a G + C content of 36% and contains a large open reading frame (ORF) encoding an RNA-dependent RNA polymerase (RdRp). BLASTp analysis revealed that the RdRp domain of HfMV1 had 28.30–50.90% sequence identity to those of members of the genusDuamitovirus and had the highest identity (50.90%) to Fusarium graminearum mitovirus 2-2 (FgMV2-2). Phylogenetic analysis further indicated that HfMV1 is a member of the genusDuamitovirus of the familyMitoviridae. This i...
Source: Archives of Virology - July 1, 2023 Category: Virology Source Type: research
Molecular characterization of a novel umbra-like virus from Thuja orientalis (arborvitae) in South Korea
AbstractA novel umbra-like virus was identified in arborvitae in South Korea using RNA sequencing (RNA-seq). The virus identified was tentatively named"arborvitae umbra-like virus" (AULV) and contained a 4,300-nucleotide genome organized into four non-structural open reading frames (ORFs). Cloning and Sanger sequencing were used to confirm the viral contig sequence and determine the size of the genome. Genome analysis indicated that ORF2 encodes an RNA-dependent RNA polymerase that is probably expressed through ribosomal frameshifting. ORF3 encodes a putative long-distance movement protein, while the functions of...
Source: Archives of Virology - July 1, 2023 Category: Virology Source Type: research
Geminiviral betasatellites: critical viral ammunition to conquer plant immunity
AbstractGeminiviruses have mastered plant cell modulation and immune invasion to ensue prolific infection. Encoding a relatively small number of multifunctional proteins, geminiviruses rely on satellites to efficiently re-wire plant immunity, thereby fostering virulence. Among the known satellites, betasatellites have been the most extensively investigated. They contribute significantly to virulence, enhance virus accumulation, and induce disease symptoms. To date, only two betasatellite proteins, βC1, and βV1, have been shown to play a crucial role in virus infection. In this review, we offer an overview of plant respon...
Source: Archives of Virology - June 30, 2023 Category: Virology Source Type: research
A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus
The objective of this systematic review is to examine the novel clinical features of Mpox and to assess the available treatment options for managing the disease in patients who are afflicted with it. We conducted a systematic search in several databases, including PubMed, Google Scholar, Cochrane Library, and the grey literature, from May 2022 to February 2023. We identified 21 eligible studies, which included 18,275 Mpox cases, for final qualitative analysis. The majority of cases were reported in men who have sex with men (MSM) and immunocompromised individuals with HIV (36.1%). The median incubation period was 7 days (I...
Source: Archives of Virology - June 29, 2023 Category: Virology Source Type: research
Structure of monkeypox virus poxin: implications for drug design
AbstractMonkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine (JYNNEOS) and an effective drug (tecovirimat), concerns remain over the possible recurrence of a viral pandemic. Like any other virus, mpox virus must overcome the immune system to replicate. Viruses have evolved various strategies to overcome both innate and adaptive immunity. Poxviruses possess an unusual nuclease, poxin, which cleaves 2'-3'-cGAMP, a cyclic dinucleotide, which is an important second messenger in the cGAS-STING signaling pathway. Here, we present the crysta...
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research
Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients
This study highlights that the therapeutic potential of remdesivir involves alteration of certain miRNA-regulated biological processes. Targeting of these miRNAs should therefore be considered for future COVID-19 treatment strategies. (Source: Archives of Virology)
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research
