A systematic review to identify novel clinical characteristics of monkeypox virus infection and therapeutic and preventive strategies to combat the virus
The objective of this systematic review is to examine the novel clinical features of Mpox and to assess the available treatment options for managing the disease in patients who are afflicted with it. We conducted a systematic search in several databases, including PubMed, Google Scholar, Cochrane Library, and the grey literature, from May 2022 to February 2023. We identified 21 eligible studies, which included 18,275 Mpox cases, for final qualitative analysis. The majority of cases were reported in men who have sex with men (MSM) and immunocompromised individuals with HIV (36.1%). The median incubation period was 7 days (I...
Source: Archives of Virology - June 29, 2023 Category: Virology Source Type: research

Structure of monkeypox virus poxin: implications for drug design
AbstractMonkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine (JYNNEOS) and an effective drug (tecovirimat), concerns remain over the possible recurrence of a viral pandemic. Like any other virus, mpox virus must overcome the immune system to replicate. Viruses have evolved various strategies to overcome both innate and adaptive immunity. Poxviruses possess an unusual nuclease, poxin, which cleaves 2'-3'-cGAMP, a cyclic dinucleotide, which is an important second messenger in the cGAS-STING signaling pathway. Here, we present the crysta...
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients
This study highlights that the therapeutic potential of remdesivir involves alteration of certain miRNA-regulated biological processes. Targeting of these miRNAs should therefore be considered for future COVID-19 treatment strategies. (Source: Archives of Virology)
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Correction to: Repurposing of artesunate, an antimalarial drug, as a potential inhibitor of hepatitis E virus
(Source: Archives of Virology)
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Structure of monkeypox virus poxin: implications for drug design
AbstractMonkeypox, or mpox, is a disease that has recently resurfaced and spread across the globe. Despite the availability of an FDA-approved vaccine (JYNNEOS) and an effective drug (tecovirimat), concerns remain over the possible recurrence of a viral pandemic. Like any other virus, mpox virus must overcome the immune system to replicate. Viruses have evolved various strategies to overcome both innate and adaptive immunity. Poxviruses possess an unusual nuclease, poxin, which cleaves 2'-3'-cGAMP, a cyclic dinucleotide, which is an important second messenger in the cGAS-STING signaling pathway. Here, we present the crysta...
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Circulating microRNA profile in response to remdesivir treatment in coronavirus disease 2019 (COVID-19) patients
This study highlights that the therapeutic potential of remdesivir involves alteration of certain miRNA-regulated biological processes. Targeting of these miRNAs should therefore be considered for future COVID-19 treatment strategies. (Source: Archives of Virology)
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Correction to: Repurposing of artesunate, an antimalarial drug, as a potential inhibitor of hepatitis E virus
(Source: Archives of Virology)
Source: Archives of Virology - June 28, 2023 Category: Virology Source Type: research

Angiotensin II and dengue
AbstractDengue is a disease caused by a flavivirus that is transmitted principally by the bite of anAedes aegypti mosquito and represents a major public-health problem. Many studies have been carried out to identify soluble factors that are involved in the pathogenesis of this infection. Cytokines, soluble factors, and oxidative stress have been reported to be involved in the development of severe disease. Angiotensin II (Ang II) is a hormone with the ability to induce the production of cytokines and soluble factors related to the inflammatory processes and coagulation disorders observed in dengue. However, a direct involv...
Source: Archives of Virology - June 27, 2023 Category: Virology Source Type: research

Broad humoral immunity generated in mice by a formulation composed of two antigens from the Delta variant of SARS-CoV-2
AbstractDue to the rapid development of new variants of SARS-CoV-2 as well as the real threat of new coronavirus zoonosis events, the development of a preventive vaccine with a broader scope of functionality is highly desirable. Previously, we reported the functionality of a nasal formulation containing the nucleocapsid protein and the receptor-binding domain (RBD) of the spike protein of the Delta variant of SARS-CoV-2 combined with the ODN-39M adjuvant. This combination induced cross-reactive immunity in mucosal and systemic compartments at the sarbecovirus level. In the present study, we explored the magnitude of the im...
Source: Archives of Virology - June 23, 2023 Category: Virology Source Type: research

The saclayvirus Aci01-1 very long and complex fiber and its receptor at the Acinetobacter baumannii surface
We report that Aci01-1 has, attached to the tail conical tip, a remarkable 146-nm-long flexible fiber with seven beads and a terminal knot. Its putative gene coding for a 241.36-kDa tail fiber protein is homologous to genes in Aci01-1-related and unrelated phages. Analysis of its 3D structure using AlphaFold provides a structural model for the fiber observed by electron microscopy. We also identified a putative receptor of the phage on the bacterial capsule that is hypothesized to interact with the Aci01-1 long fiber. (Source: Archives of Virology)
Source: Archives of Virology - June 23, 2023 Category: Virology Source Type: research

Four distinct isolates of a novel polymycovirus identified in Setosphaeria turcica
AbstractIsolation and analysis of double-stranded RNA (dsRNA) from the phytopathogenic fungusSetosphaeria turcica f. sp.zeae revealed the presence of a new double-stranded RNA (dsRNA) virus, tentatively named"Setosphaeria turcica polymycovirus 2" (StPmV2). The genome of StPmV2 consists of five segments (dsRNA1-5), ranging in size from 965 bp to 2462 bp. Each dsRNA contains one  open reading frame (ORF) flanked by 5' and 3' untranslated regions (UTRs) with conserved terminal sequences. The putative protein encoded by dsRNA1 shows 64.52% amino acid sequence identity to the RNA-dependent RNA polymerase (RdRp) of t...
Source: Archives of Virology - June 23, 2023 Category: Virology Source Type: research

The dynamics of SARS-CoV-2 infection in unvaccinated and vaccinated populations in Mumbai, India, between 28 December 2020 and 30 August 2021
AbstractThe emergence and evolution of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) variants that could compromise vaccine efficacy (VE) with re-infections in immunized individuals have necessitated continuous surveillance of VE. Here, the occurrence and dynamics of SARS-CoV-2 infections in the context of vaccination during the second wave of infection in Mumbai were evaluated. RT-PCR cycle threshold (Ct) values of the open reading frame (ORF)/envelope (E)/nucleocapsid (N) genes obtained from a total of 42415 samples, comprising unvaccinated (96.88%) and vaccinated cases (3.12%) were analyzed between Decemb...
Source: Archives of Virology - June 23, 2023 Category: Virology Source Type: research

SARS-CoV-2: analysis of the effects of mutations in non-structural proteins
In this study, we used full genome sequences of SARS-CoV-2 variants to predict structural changes in viral proteins. These sequences were obtained from the Global Initiative on Sharing Avian Influenza Data (GISAID), and a set of significant mutations were identified in each of the non-structural proteins (NSP1-16) and structural proteins, including the envelope, nucleocapsid, membrane, and spike proteins. The mutations were characterized as stabilizing or destabilizing based on their effect on protein dynamics and stability, and their impact on structure and function was evaluated. Among all of the proteins, NSP6 stands ou...
Source: Archives of Virology - June 21, 2023 Category: Virology Source Type: research