Unemployment Insurance and Mortality Among the Long-Term Unemployed: A Population-Based Matched Cohort Study
Am J Epidemiol. 2021 May 14:kwab144. doi: 10.1093/aje/kwab144. Online ahead of print.ABSTRACTUnemployment insurance is hypothesized to play an important role in mitigating the adverse health consequences of job loss. In this prospective cohort study, we examined whether receiving unemployment benefits is associated with lower mortality among the long-term unemployed. Census records from the 2006 Canadian Census Health and Environment Cohort (n=2,105,595) were linked to mortality data from 2006 to 2016. Flexible parametric survival analysis and propensity score matching were used to model time-varying relationships between ...
Source: Am J Epidemiol - May 17, 2021 Category: Epidemiology Authors: Faraz Vahid Shahidi Abtin Parnia Source Type: research

The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design
Am J Epidemiol. 2021 May 12:kwab141. doi: 10.1093/aje/kwab141. Online ahead of print.ABSTRACTThe prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children's early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2017-2021; ClinicalTrials.org ID: NCT04873518) follows 939 participants from a pregnancy cohort in Québec (Canada) as they transition to kindergarten and first grade to examine thes...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Charlie Rioux Sophie Parent Natalie Castellanos-Ryan Isabelle Archambault Michel Boivin Catherine M Herba Sonia J Lupien Isabelle Marc Gina Muckle William D Fraser Jean R S éguin Source Type: research

Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health across the Lifespan
This study included 40,875 participants from 7 large, population-based longitudinal epidemiology studies (1948-2016). We multiply imputed the participant's lifespan CRFs and events using the available records based on a joint multi-level imputation model. To validate the imputed values, we partially removed the observed data, then compared the imputed and observed values. The complete lifespan synthetic dataset reflected the original observed data trends well. Among our validation sample, the distributions of imputed CRFs and events were close to the observed but with less variability. Bland-Altman plots indicated that the...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Hongyan Ning Amy Krefman Lihui Zhao John T Wilkins Donald M Lloyd-Jones Juned Siddique Norrina B Allen Source Type: research

The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design
Am J Epidemiol. 2021 May 12:kwab141. doi: 10.1093/aje/kwab141. Online ahead of print.ABSTRACTThe prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children's early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2017-2021; ClinicalTrials.org ID: NCT04873518) follows 939 participants from a pregnancy cohort in Québec (Canada) as they transition to kindergarten and first grade to examine thes...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Charlie Rioux Sophie Parent Natalie Castellanos-Ryan Isabelle Archambault Michel Boivin Catherine M Herba Sonia J Lupien Isabelle Marc Gina Muckle William D Fraser Jean R S éguin Source Type: research

Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health across the Lifespan
This study included 40,875 participants from 7 large, population-based longitudinal epidemiology studies (1948-2016). We multiply imputed the participant's lifespan CRFs and events using the available records based on a joint multi-level imputation model. To validate the imputed values, we partially removed the observed data, then compared the imputed and observed values. The complete lifespan synthetic dataset reflected the original observed data trends well. Among our validation sample, the distributions of imputed CRFs and events were close to the observed but with less variability. Bland-Altman plots indicated that the...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Hongyan Ning Amy Krefman Lihui Zhao John T Wilkins Donald M Lloyd-Jones Juned Siddique Norrina B Allen Source Type: research

The 3D-Transition Study: Objectives, Methods, and Implementation of an Innovative Planned Missing Data Design
Am J Epidemiol. 2021 May 12:kwab141. doi: 10.1093/aje/kwab141. Online ahead of print.ABSTRACTThe prevalence of mental health problems represents a significant burden on school and community health resources as early as preschool. Reducing this burden requires a better understanding of the developmental mechanisms linking children's early vulnerabilities with mental health after the transition to formal schooling. The 3D-Transition study (2017-2021; ClinicalTrials.org ID: NCT04873518) follows 939 participants from a pregnancy cohort in Québec (Canada) as they transition to kindergarten and first grade to examine thes...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Charlie Rioux Sophie Parent Natalie Castellanos-Ryan Isabelle Archambault Michel Boivin Catherine M Herba Sonia J Lupien Isabelle Marc Gina Muckle William D Fraser Jean R S éguin Source Type: research

Development and Validation of a Large Synthetic Cohort for the Study of Cardiovascular Health across the Lifespan
This study included 40,875 participants from 7 large, population-based longitudinal epidemiology studies (1948-2016). We multiply imputed the participant's lifespan CRFs and events using the available records based on a joint multi-level imputation model. To validate the imputed values, we partially removed the observed data, then compared the imputed and observed values. The complete lifespan synthetic dataset reflected the original observed data trends well. Among our validation sample, the distributions of imputed CRFs and events were close to the observed but with less variability. Bland-Altman plots indicated that the...
Source: Am J Epidemiol - May 14, 2021 Category: Epidemiology Authors: Hongyan Ning Amy Krefman Lihui Zhao John T Wilkins Donald M Lloyd-Jones Juned Siddique Norrina B Allen Source Type: research

Urban Densification and Physical Activity Change: A 12-year Longitudinal Study of Australian Adults
We examined associations of population density changes in urban areas with adults' physical activity changes over 12 years using the Australian Diabetes, Obesity and Lifestyle study (1999-2012). The analytical sample contained 2,354 participants, who stayed at the same residential address throughout the study period in metropolitan and regional cities (42 study areas). Census-based population density measures were calculated for 1-km radius buffers around their homes. Population density change was estimated using linear growth models. Two-level linear regression models assessed associations between changes in population de...
Source: Am J Epidemiol - May 13, 2021 Category: Epidemiology Authors: Manoj Chandrabose Neville Owen Nyssa Hadgraft Billie Giles-Corti Takemi Sugiyama Source Type: research

Outcome Stratified Analysis of Biomarker Trajectories for Patients With SARS-CoV-2 Infection
Am J Epidemiol. 2021 May 12:kwab138. doi: 10.1093/aje/kwab138. Online ahead of print.ABSTRACTLongitudinal trajectories of vital signs and biomarkers during admission remain poorly characterized for COVID-19 patients despite their potential to provide critical insights about disease progression. We studied 1884 patients with SARS-CoV2 infection from 3/4/2020-6/25/2020 within one Maryland hospital system and used a retrospective longitudinal framework with linear mixed-effects models to investigate relevant biomarker trajectories leading up to three critical outcomes: mechanical ventilation, discharge, and death. Trajectorie...
Source: Am J Epidemiol - May 13, 2021 Category: Epidemiology Authors: Mary G Bowring Zitong Wang Yizhen Xu Joshua Betz John Muschelli Brian T Garibaldi Scott L Zeger Source Type: research

Association between Kidney Function, Proteinuria and the Risk of Kidney Cancer: a Nationwide Cohort Study involving 10 Million Participants
We examined the impact of estimated glomerular filtration rate (eGFR), dipstick proteinuria, and interactive associations of the two factors on the risk of incident kidney cancer. During a median follow-up of 7.3 years, 10,634 kidney cancers were identified. After adjustment for multiple confounders, participants with reduced eGFR were associated with an increased risk of kidney cancer (adjusted hazard ratio = 1.18, 95% confidence interval: 1.01, 1.39 for eGFR
Source: Am J Epidemiol - May 13, 2021 Category: Epidemiology Authors: Jinsung Park Dong Wook Shin Kyungdo Han Dahye Kim Sohyun Chun Hye Ryoun Jang Source Type: research

Religiosity and mental wellbeing among members of majority and minority religions: findings from Understanding Society, The UK Household Longitudinal Study
We examined differences in mental wellbeing and associations between mental wellbeing and religiosity among the religiously unaffiliated, white and non-white Christians, Muslims of Pakistani, Bangladeshi and other ethnicities, and other minority ethnoreligious groups. We used four waves of Understanding Society, a UK longitudinal household panel (2009-2013, N=50922). We adjusted for potential confounders (including socioeconomic factors and personality) and for household fixed effects to account for household level unobserved confounding factors. Compared with those with no religious affiliation, Pakistani and Bangladeshi ...
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Ozan Aksoy David Bann Meg E Fluharty Alita Nandi Source Type: research

Religious Service Attendance and Implications for Clinical Care, Community Participation and Public Health
Discussion is given to potential future research directions, and the challenges and opportunities for public health community promotion efforts.PMID:33977296 | DOI:10.1093/aje/kwab134 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Tyler J VanderWeele Tracy A Balboni Howard K Koh Source Type: research

Religion and health in a diverse and increasingly secular context: two sets of questions to improve inference and translation
Am J Epidemiol. 2021 May 11:kwab135. doi: 10.1093/aje/kwab135. Online ahead of print.NO ABSTRACTPMID:33977299 | DOI:10.1093/aje/kwab135 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: David Bann Ozan Aksoy Source Type: research

Time-series Analysis of Fentanyl Concentration in the Unregulated Opioid Drug Supply in a Canadian Setting
Am J Epidemiol. 2021 May 11:kwab129. doi: 10.1093/aje/kwab129. Online ahead of print.ABSTRACTNorth America has been contending with an unregulated street drug supply in which opioids are often adulterated with illicitly manufactured fentanyl. The unpredictability of composition may result in an increased risk of overdose due to unexpected elevated concentrations of the high-potency drug. Using data from a community-based drug checking project, we evaluated trends in fentanyl concentration of illicit opioids in the context of an overdose epidemic. Using a quantification model for fentanyl hydrochloride, historical Fourier-t...
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Samuel Tobias Cameron J Grant Richard Laing Jaime Arredondo Mark Lysyshyn Jane Buxton Kenneth W Tupper Evan Wood Lianping Ti Source Type: research

Religiosity and mental wellbeing among members of majority and minority religions: findings from Understanding Society, The UK Household Longitudinal Study
We examined differences in mental wellbeing and associations between mental wellbeing and religiosity among the religiously unaffiliated, white and non-white Christians, Muslims of Pakistani, Bangladeshi and other ethnicities, and other minority ethnoreligious groups. We used four waves of Understanding Society, a UK longitudinal household panel (2009-2013, N=50922). We adjusted for potential confounders (including socioeconomic factors and personality) and for household fixed effects to account for household level unobserved confounding factors. Compared with those with no religious affiliation, Pakistani and Bangladeshi ...
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Ozan Aksoy David Bann Meg E Fluharty Alita Nandi Source Type: research

Religious Service Attendance and Implications for Clinical Care, Community Participation and Public Health
Discussion is given to potential future research directions, and the challenges and opportunities for public health community promotion efforts.PMID:33977296 | DOI:10.1093/aje/kwab134 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Tyler J VanderWeele Tracy A Balboni Howard K Koh Source Type: research

Religion and health in a diverse and increasingly secular context: two sets of questions to improve inference and translation
Am J Epidemiol. 2021 May 11:kwab135. doi: 10.1093/aje/kwab135. Online ahead of print.NO ABSTRACTPMID:33977299 | DOI:10.1093/aje/kwab135 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: David Bann Ozan Aksoy Source Type: research

Time-series Analysis of Fentanyl Concentration in the Unregulated Opioid Drug Supply in a Canadian Setting
Am J Epidemiol. 2021 May 11:kwab129. doi: 10.1093/aje/kwab129. Online ahead of print.ABSTRACTNorth America has been contending with an unregulated street drug supply in which opioids are often adulterated with illicitly manufactured fentanyl. The unpredictability of composition may result in an increased risk of overdose due to unexpected elevated concentrations of the high-potency drug. Using data from a community-based drug checking project, we evaluated trends in fentanyl concentration of illicit opioids in the context of an overdose epidemic. Using a quantification model for fentanyl hydrochloride, historical Fourier-t...
Source: Am J Epidemiol - May 12, 2021 Category: Epidemiology Authors: Samuel Tobias Cameron J Grant Richard Laing Jaime Arredondo Mark Lysyshyn Jane Buxton Kenneth W Tupper Evan Wood Lianping Ti Source Type: research

Transportability from Randomized Trials to Clinical Care: On Initial HIV Treatment with Efavirenz and Suicidal Thoughts or Behaviors
Am J Epidemiol. 2021 May 10:kwab136. doi: 10.1093/aje/kwab136. Online ahead of print.ABSTRACTEfavirenz was associated with increased suicidal thoughts/behaviors in an analysis of randomized trials. However, analyses of observational data have found no evidence of increased hazard. To assess whether population differences explain this divergence we transported the effect of efavirenz from these trials to a specific target population. Using inverse odds weights and multiple imputation, the effect of efavirenz on suicidal thoughts/behaviors in these randomized trials (enrolled 2001-2007) was transported to a trials-eligible c...
Source: Am J Epidemiol - May 11, 2021 Category: Epidemiology Authors: Katie R Mollan Brian W Pence Steven Xu Jessie K Edwards W Christopher Mathews Conall O'Cleirigh Heidi M Crane Ellen F Eaton Ann C Collier Ann Marie K Weideman Daniel Westreich Stephen R Cole Camlin Tierney Angela M Bengtson For The Cfar Network Of Integra Source Type: research

Transportability from Randomized Trials to Clinical Care: On Initial HIV Treatment with Efavirenz and Suicidal Thoughts or Behaviors
Am J Epidemiol. 2021 May 10:kwab136. doi: 10.1093/aje/kwab136. Online ahead of print.ABSTRACTEfavirenz was associated with increased suicidal thoughts/behaviors in an analysis of randomized trials. However, analyses of observational data have found no evidence of increased hazard. To assess whether population differences explain this divergence we transported the effect of efavirenz from these trials to a specific target population. Using inverse odds weights and multiple imputation, the effect of efavirenz on suicidal thoughts/behaviors in these randomized trials (enrolled 2001-2007) was transported to a trials-eligible c...
Source: Am J Epidemiol - May 11, 2021 Category: Epidemiology Authors: Katie R Mollan Brian W Pence Steven Xu Jessie K Edwards W Christopher Mathews Conall O'Cleirigh Heidi M Crane Ellen F Eaton Ann C Collier Ann Marie K Weideman Daniel Westreich Stephen R Cole Camlin Tierney Angela M Bengtson For The Cfar Network Of Integra Source Type: research

2020 Articles of the Year and Reviewers of the Year
Am J Epidemiol. 2021 May 6:kwab128. doi: 10.1093/aje/kwab128. Online ahead of print.NO ABSTRACTPMID:33959746 | DOI:10.1093/aje/kwab128 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 7, 2021 Category: Epidemiology Source Type: research

2020 Articles of the Year and Reviewers of the Year
Am J Epidemiol. 2021 May 6:kwab128. doi: 10.1093/aje/kwab128. Online ahead of print.NO ABSTRACTPMID:33959746 | DOI:10.1093/aje/kwab128 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 7, 2021 Category: Epidemiology Source Type: research

2020 Articles of the Year and Reviewers of the Year
Am J Epidemiol. 2021 May 6:kwab128. doi: 10.1093/aje/kwab128. Online ahead of print.NO ABSTRACTPMID:33959746 | DOI:10.1093/aje/kwab128 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 7, 2021 Category: Epidemiology Source Type: research

2020 Articles of the Year and Reviewers of the Year
Am J Epidemiol. 2021 May 6:kwab128. doi: 10.1093/aje/kwab128. Online ahead of print.NO ABSTRACTPMID:33959746 | DOI:10.1093/aje/kwab128 (Source: Am J Epidemiol)
Source: Am J Epidemiol - May 7, 2021 Category: Epidemiology Source Type: research

Association of Medicaid Expansion with Suicide Deaths among Nonelderly U.S. Adults
We examined the association of Medicaid expansion with rates of suicide death among nonelderly adults per 100,000 population using a difference-in-differences approach. Adjusting for state-level confounders, Medicaid expansion states had 1.2 (95% CI -2.5, 0.1) fewer suicide deaths per 100,000 population per year in the post-expansion period than would have been expected if they had followed the same trend in suicide rates as non-expansion states. Medicaid expansion was associated with reductions in suicide rates among women, men, those 30-44 years, white, non-Hispanic individuals, and those without a college degree. Medica...
Source: Am J Epidemiol - May 5, 2021 Category: Epidemiology Authors: Anna E Austin Rebecca B Naumann Nicole A Short Source Type: research

Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101695 American Adults
Am J Epidemiol. 2021 May 4:kwab131. doi: 10.1093/aje/kwab131. Online ahead of print.ABSTRACTNo epidemiological studies have been conducted to assess the association of dietary vitamin K intake with the risk of pancreatic cancer. We used prospective data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial between 1993 and 2009 to fill this gap. A total of 101695 subjects were identified. Dietary intakes of phylloquinone (vitamin K1), menaquinones (vitamin K2), and dihydrophylloquinone (dihydrovitamin K1) were assessed with a food frequency questionnaire. Cox regression was applied to calculate hazard rat...
Source: Am J Epidemiol - May 5, 2021 Category: Epidemiology Authors: Dao-Wu Yu Qu-Jin Li Long Cheng Peng-Fei Yang Wei-Ping Sun Yang Peng Jie-Jun Hu Jing-Jing Wu Jian-Ping Gong Guo-Chao Zhong Source Type: research

Association of Medicaid Expansion with Suicide Deaths among Nonelderly U.S. Adults
We examined the association of Medicaid expansion with rates of suicide death among nonelderly adults per 100,000 population using a difference-in-differences approach. Adjusting for state-level confounders, Medicaid expansion states had 1.2 (95% CI -2.5, 0.1) fewer suicide deaths per 100,000 population per year in the post-expansion period than would have been expected if they had followed the same trend in suicide rates as non-expansion states. Medicaid expansion was associated with reductions in suicide rates among women, men, those 30-44 years, white, non-Hispanic individuals, and those without a college degree. Medica...
Source: Am J Epidemiol - May 5, 2021 Category: Epidemiology Authors: Anna E Austin Rebecca B Naumann Nicole A Short Source Type: research

Dietary Vitamin K Intake and the Risk of Pancreatic Cancer: A Prospective Study of 101695 American Adults
Am J Epidemiol. 2021 May 4:kwab131. doi: 10.1093/aje/kwab131. Online ahead of print.ABSTRACTNo epidemiological studies have been conducted to assess the association of dietary vitamin K intake with the risk of pancreatic cancer. We used prospective data from the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial between 1993 and 2009 to fill this gap. A total of 101695 subjects were identified. Dietary intakes of phylloquinone (vitamin K1), menaquinones (vitamin K2), and dihydrophylloquinone (dihydrovitamin K1) were assessed with a food frequency questionnaire. Cox regression was applied to calculate hazard rat...
Source: Am J Epidemiol - May 5, 2021 Category: Epidemiology Authors: Dao-Wu Yu Qu-Jin Li Long Cheng Peng-Fei Yang Wei-Ping Sun Yang Peng Jie-Jun Hu Jing-Jing Wu Jian-Ping Gong Guo-Chao Zhong Source Type: research

A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator
Am J Epidemiol. 2021 May 2:kwab124. doi: 10.1093/aje/kwab124. Online ahead of print.ABSTRACTEvaluating gene by environment (G$\times$E) interaction under an additive risk model (i.e. additive interaction) has gained wider attention. Recently, statistical tests have been proposed for detecting additive interaction that utilize an assumption on G-E independence to boost power, which do not rely on restrictive genetic models such as dominant or recessive models. However, a major limitation of these methods is a sharp increase in type I error when this assumption is violated. Our goal is to develop a robust test for additive G...
Source: Am J Epidemiol - May 4, 2021 Category: Epidemiology Authors: Nilotpal Sanyal Valerio Napolioni Matthieu de Rochemonteix Micha ël E Belloy Neil E Caporaso Maria Teresa Landi Michael D Greicius Nilanjan Chatterjee Summer S Han Source Type: research

A Robust Test for Additive Gene-Environment Interaction Under the Trend Effect of Genotype Using an Empirical Bayes-Type Shrinkage Estimator
Am J Epidemiol. 2021 May 2:kwab124. doi: 10.1093/aje/kwab124. Online ahead of print.ABSTRACTEvaluating gene by environment (G$\times$E) interaction under an additive risk model (i.e. additive interaction) has gained wider attention. Recently, statistical tests have been proposed for detecting additive interaction that utilize an assumption on G-E independence to boost power, which do not rely on restrictive genetic models such as dominant or recessive models. However, a major limitation of these methods is a sharp increase in type I error when this assumption is violated. Our goal is to develop a robust test for additive G...
Source: Am J Epidemiol - May 4, 2021 Category: Epidemiology Authors: Nilotpal Sanyal Valerio Napolioni Matthieu de Rochemonteix Micha ël E Belloy Neil E Caporaso Maria Teresa Landi Michael D Greicius Nilanjan Chatterjee Summer S Han Source Type: research

The Longitudinal Association Between Retirement and Depression: A Systematic Review and Meta-Analysis
Am J Epidemiol. 2021 Apr 29:kwab125. doi: 10.1093/aje/kwab125. Online ahead of print.ABSTRACTThe purpose of this study was to collect the evidence of the relationship between retirement and depression through meta-analysis, and further analyze the heterogeneity of results. The quality of the studies was rated based on ten predefined criteria. We searched articles published between 1980 and 2020 and a total of 25 longitudinal studies were included in the meta-analysis. The meta-analysis results showed that retirement was associated with more depressive symptoms (d =0.044, 95%CI 0.008 to 0.080). The association of involuntar...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Wentao Li Xin Ye Dawei Zhu Ping He Source Type: research

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology
Am J Epidemiol. 2021 Apr 29:kwab119. doi: 10.1093/aje/kwab119. Online ahead of print.ABSTRACTWe aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish C...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Rajani Sharma Elizabeth C Verna Tracey G Simon Jonas S öderling Hannes Hagstr öm Peter H R Green Jonas F Ludvigsson Source Type: research

The Longitudinal Association Between Retirement and Depression: A Systematic Review and Meta-Analysis
Am J Epidemiol. 2021 Apr 29:kwab125. doi: 10.1093/aje/kwab125. Online ahead of print.ABSTRACTThe purpose of this study was to collect the evidence of the relationship between retirement and depression through meta-analysis, and further analyze the heterogeneity of results. The quality of the studies was rated based on ten predefined criteria. We searched articles published between 1980 and 2020 and a total of 25 longitudinal studies were included in the meta-analysis. The meta-analysis results showed that retirement was associated with more depressive symptoms (d =0.044, 95%CI 0.008 to 0.080). The association of involuntar...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Wentao Li Xin Ye Dawei Zhu Ping He Source Type: research

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology
Am J Epidemiol. 2021 Apr 29:kwab119. doi: 10.1093/aje/kwab119. Online ahead of print.ABSTRACTWe aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish C...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Rajani Sharma Elizabeth C Verna Tracey G Simon Jonas S öderling Hannes Hagstr öm Peter H R Green Jonas F Ludvigsson Source Type: research

The Longitudinal Association Between Retirement and Depression: A Systematic Review and Meta-Analysis
Am J Epidemiol. 2021 Apr 29:kwab125. doi: 10.1093/aje/kwab125. Online ahead of print.ABSTRACTThe purpose of this study was to collect the evidence of the relationship between retirement and depression through meta-analysis, and further analyze the heterogeneity of results. The quality of the studies was rated based on ten predefined criteria. We searched articles published between 1980 and 2020 and a total of 25 longitudinal studies were included in the meta-analysis. The meta-analysis results showed that retirement was associated with more depressive symptoms (d =0.044, 95%CI 0.008 to 0.080). The association of involuntar...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Wentao Li Xin Ye Dawei Zhu Ping He Source Type: research

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology
Am J Epidemiol. 2021 Apr 29:kwab119. doi: 10.1093/aje/kwab119. Online ahead of print.ABSTRACTWe aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish C...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Rajani Sharma Elizabeth C Verna Tracey G Simon Jonas S öderling Hannes Hagstr öm Peter H R Green Jonas F Ludvigsson Source Type: research

The Longitudinal Association Between Retirement and Depression: A Systematic Review and Meta-Analysis
Am J Epidemiol. 2021 Apr 29:kwab125. doi: 10.1093/aje/kwab125. Online ahead of print.ABSTRACTThe purpose of this study was to collect the evidence of the relationship between retirement and depression through meta-analysis, and further analyze the heterogeneity of results. The quality of the studies was rated based on ten predefined criteria. We searched articles published between 1980 and 2020 and a total of 25 longitudinal studies were included in the meta-analysis. The meta-analysis results showed that retirement was associated with more depressive symptoms (d =0.044, 95%CI 0.008 to 0.080). The association of involuntar...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Wentao Li Xin Ye Dawei Zhu Ping He Source Type: research

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology
Am J Epidemiol. 2021 Apr 29:kwab119. doi: 10.1093/aje/kwab119. Online ahead of print.ABSTRACTWe aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish C...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Rajani Sharma Elizabeth C Verna Tracey G Simon Jonas S öderling Hannes Hagstr öm Peter H R Green Jonas F Ludvigsson Source Type: research

The Longitudinal Association Between Retirement and Depression: A Systematic Review and Meta-Analysis
Am J Epidemiol. 2021 Apr 29:kwab125. doi: 10.1093/aje/kwab125. Online ahead of print.ABSTRACTThe purpose of this study was to collect the evidence of the relationship between retirement and depression through meta-analysis, and further analyze the heterogeneity of results. The quality of the studies was rated based on ten predefined criteria. We searched articles published between 1980 and 2020 and a total of 25 longitudinal studies were included in the meta-analysis. The meta-analysis results showed that retirement was associated with more depressive symptoms (d =0.044, 95%CI 0.008 to 0.080). The association of involuntar...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Wentao Li Xin Ye Dawei Zhu Ping He Source Type: research

Cancer Risk in Patients with Autoimmune Hepatitis: A Nationwide Population-Based Cohort Study with Histopathology
Am J Epidemiol. 2021 Apr 29:kwab119. doi: 10.1093/aje/kwab119. Online ahead of print.ABSTRACTWe aimed to determine the risk of incident cancer in autoimmune hepatitis (AIH) compared to the general population and siblings. AIH was defined by the presence of a medical diagnosis of AIH and a liver biopsy in a nationwide Swedish population-based cohort study. We identified 5,268 adults with AIH diagnosed 1969-2016 and 22,996 matched general population reference individuals and 4,170 sibling comparators. Using Cox regression, hazard ratios (HRs) were determined for any incident cancer and sub-types determined from the Swedish C...
Source: Am J Epidemiol - April 29, 2021 Category: Epidemiology Authors: Rajani Sharma Elizabeth C Verna Tracey G Simon Jonas S öderling Hannes Hagstr öm Peter H R Green Jonas F Ludvigsson Source Type: research

Body-Mass Index and Mortality among Adults with Incident Myocardial Infarction
We examined the relationship of BMI before and after MI, and change in weight, with all-cause mortality among participants of the Nurses' Health Study (1980-2016) and Health Professionals Follow up Study (1988-2016) cohorts. During up to 36 years of follow-up, we documented 4856 incident nonfatal MI cases, among whom 2407 died. For the pre-MI and post-MI BMI, overweight was not associated with lower mortality. Obesity (BMI ≥ 30 kg/m2) was associated with higher risk of mortality. Compared to participants with post-MI BMI of 22.5-24.9, HRs were 1.16, 95% CI: 1.01, 1.34 for BMI 30-34.9 and 1.52, 95% CI: 1.27, 1.83 for BMI...
Source: Am J Epidemiol - April 28, 2021 Category: Epidemiology Authors: Laila Al-Shaar Yanping Li Eric B Rimm Jo Ann E Manson Bernard Rosner Frank B Hu Meir J Stampfer Walter C Willett Source Type: research

Association Between Hurricane Sandy and Emergency Department Visits In New York City By Age and Cause
We examined the relative change in cause-specific emergency department (ED) visits among residents of New York City during and after Hurricane Sandy, a tropical cyclone that affected the northeastern United States in October 2012. We used quasi-Poisson constrained distributed lag models to compare the number of ED visits on and after Hurricane Sandy to all other days, 2005-2014, adjusting for temporal trends. Among residents aged ≥ 65 years, Hurricane Sandy was associated with a higher rate of ED visits due to injuries and poisoning (RR: 1.19, [95% CI: 1.10, 1.28]), respiratory disease (1.35, [1.21, 1.49]), cardiovascul...
Source: Am J Epidemiol - April 28, 2021 Category: Epidemiology Authors: Kate R Weinberger Erin R Kulick Amelia K Boehme Shengzhi Sun Francesca Dominici Gregory A Wellenius Source Type: research

COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
Am J Epidemiol. 2021 Apr 22:kwab120. doi: 10.1093/aje/kwab120. Online ahead of print.ABSTRACTConsortium-based research is crucial for producing reliable high-quality findings but existing tools for consortium studies have important drawbacks with respect to data protection, ease of deployment, and analytical rigor. To address these concerns, we developed COnsortium of METabolomics Studies (COMETS) Analytics to support and streamline consortium-based analyses of metabolomics and other omics data. The application requires no specialized expertise and can be run locally to guarantee data protection or through a web-based serv...
Source: Am J Epidemiol - April 23, 2021 Category: Epidemiology Authors: Marinella Temprosa Steven C Moore Krista A Zanetti Nathan Appel David Ruggieri Kaitlyn M Mazzilli Kai-Ling Chen Rachel S Kelly Jessica A Lasky-Su Erikka Loftfield Kathleen McClain Brian Park Laura Trijsburg Oana A Zeleznik Ewy A Math é Source Type: research

COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
Am J Epidemiol. 2021 Apr 22:kwab120. doi: 10.1093/aje/kwab120. Online ahead of print.ABSTRACTConsortium-based research is crucial for producing reliable high-quality findings but existing tools for consortium studies have important drawbacks with respect to data protection, ease of deployment, and analytical rigor. To address these concerns, we developed COnsortium of METabolomics Studies (COMETS) Analytics to support and streamline consortium-based analyses of metabolomics and other omics data. The application requires no specialized expertise and can be run locally to guarantee data protection or through a web-based serv...
Source: Am J Epidemiol - April 23, 2021 Category: Epidemiology Authors: Marinella Temprosa Steven C Moore Krista A Zanetti Nathan Appel David Ruggieri Kaitlyn M Mazzilli Kai-Ling Chen Rachel S Kelly Jessica A Lasky-Su Erikka Loftfield Kathleen McClain Brian Park Laura Trijsburg Oana A Zeleznik Ewy A Math é Source Type: research

COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
Am J Epidemiol. 2021 Apr 22:kwab120. doi: 10.1093/aje/kwab120. Online ahead of print.ABSTRACTConsortium-based research is crucial for producing reliable high-quality findings but existing tools for consortium studies have important drawbacks with respect to data protection, ease of deployment, and analytical rigor. To address these concerns, we developed COnsortium of METabolomics Studies (COMETS) Analytics to support and streamline consortium-based analyses of metabolomics and other omics data. The application requires no specialized expertise and can be run locally to guarantee data protection or through a web-based serv...
Source: Am J Epidemiol - April 23, 2021 Category: Epidemiology Authors: Marinella Temprosa Steven C Moore Krista A Zanetti Nathan Appel David Ruggieri Kaitlyn M Mazzilli Kai-Ling Chen Rachel S Kelly Jessica A Lasky-Su Erikka Loftfield Kathleen McClain Brian Park Laura Trijsburg Oana A Zeleznik Ewy A Math é Source Type: research

COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
Am J Epidemiol. 2021 Apr 22:kwab120. doi: 10.1093/aje/kwab120. Online ahead of print.ABSTRACTConsortium-based research is crucial for producing reliable high-quality findings but existing tools for consortium studies have important drawbacks with respect to data protection, ease of deployment, and analytical rigor. To address these concerns, we developed COnsortium of METabolomics Studies (COMETS) Analytics to support and streamline consortium-based analyses of metabolomics and other omics data. The application requires no specialized expertise and can be run locally to guarantee data protection or through a web-based serv...
Source: Am J Epidemiol - April 23, 2021 Category: Epidemiology Authors: Marinella Temprosa Steven C Moore Krista A Zanetti Nathan Appel David Ruggieri Kaitlyn M Mazzilli Kai-Ling Chen Rachel S Kelly Jessica A Lasky-Su Erikka Loftfield Kathleen McClain Brian Park Laura Trijsburg Oana A Zeleznik Ewy A Math é Source Type: research

COMETS Analytics: An online tool for analyzing and meta-analyzing metabolomics data in large research consortia
Am J Epidemiol. 2021 Apr 22:kwab120. doi: 10.1093/aje/kwab120. Online ahead of print.ABSTRACTConsortium-based research is crucial for producing reliable high-quality findings but existing tools for consortium studies have important drawbacks with respect to data protection, ease of deployment, and analytical rigor. To address these concerns, we developed COnsortium of METabolomics Studies (COMETS) Analytics to support and streamline consortium-based analyses of metabolomics and other omics data. The application requires no specialized expertise and can be run locally to guarantee data protection or through a web-based serv...
Source: Am J Epidemiol - April 23, 2021 Category: Epidemiology Authors: Marinella Temprosa Steven C Moore Krista A Zanetti Nathan Appel David Ruggieri Kaitlyn M Mazzilli Kai-Ling Chen Rachel S Kelly Jessica A Lasky-Su Erikka Loftfield Kathleen McClain Brian Park Laura Trijsburg Oana A Zeleznik Ewy A Math é Source Type: research

California's Mental Health Services Act and Mortality Due to Suicide, Homicide, and Acute Effects of Alcohol: A Synthetic Control Application
Am J Epidemiol. 2021 Apr 21:kwab123. doi: 10.1093/aje/kwab123. Online ahead of print.ABSTRACTCalifornia's Mental Health Services Act (MHSA) substantially expanded funding of County mental health services through a state tax, and led to broad prevention efforts and intensive services for individuals experiencing serious mental disorders. We estimated the associations between MHSA and mortality due to suicide, homicide, and acute effects of alcohol. Using annual cause-specific mortality data for each US state and the District of Columbia from 1976-2015, we used a generalization of the quasi-experimental synthetic control met...
Source: Am J Epidemiol - April 22, 2021 Category: Epidemiology Authors: Scott C Zimmerman Ellicott C Matthay Kara E Rudolph Dana E Goin Kriszta Farkas Christopher L Rowe Jennifer Ahern Source Type: research

Predicting Sex-Specific Non-Fatal Suicide Attempt Risk Using Machine Learning and Data from Danish National Registries
Am J Epidemiol. 2021 Apr 20:kwab112. doi: 10.1093/aje/kwab112. Online ahead of print.ABSTRACTSuicide attempts are a leading cause of injury globally. Accurate prediction of suicide attempts may offer opportunities for prevention. This case-cohort study used machine learning to examine sex-specific risk profiles for suicide attempts in Danish nationwide registry data. Cases were all persons who made a non-fatal suicide attempt between 1995 and 2015 (n = 22,974); the subcohort was a 5% random sample of the population at risk on January 1, 1995 (n = 265,183). We developed sex-stratified classification trees and random forests...
Source: Am J Epidemiol - April 20, 2021 Category: Epidemiology Authors: Jaimie L Gradus Anthony J Rosellini Erzs ébet Horváth-Puhó Tammy Jiang Amy E Street Isaac Galatzer-Levy Timothy L Lash Henrik T S ørensen Source Type: research

New directions in machine learning analyses of administrative data to prevent suicide-related behaviors
Am J Epidemiol. 2021 Apr 20:kwab111. doi: 10.1093/aje/kwab111. Online ahead of print.ABSTRACTThis issue contains a thoughtful report by Gradus et al. on a machine learning (ML) analysis of administrative variables to predict suicide attempts over two decades throughout Denmark. This is one of numerous recent studies that document strong concentration of risk of suicide-related behaviors (SRBs) among patients with high scores on ML models. The clear exposition of Gradus et al. provides an opportunity to review major challenges in developing, interpreting, and using such models: defining appropriate controls and time horizon...
Source: Am J Epidemiol - April 20, 2021 Category: Epidemiology Authors: Robert M Bossarte Chris J Kennedy Alex Luedtke Matthew K Nock Jordan W Smoller Cara Stokes Ronald C Kessler Source Type: research