Impact of Alcohol on HIV Disease Pathogenesis, Comorbidities and Aging: Integrating Preclinical and Clinical Findings
AbstractAlcohol ’s multisystemic effects impact HIV disease pathogenesis and increase the risk for comorbidities in persons living with HIV (PLWH). The increased number of aging PLWH increases the potential for alcohol to enhance the risk for comorbidities. Integration of epidemiological, preclinical and translat ional studies provide an overarching view of the impact of heavy alcohol consumption on HIV risk, pathogenesis, treatment and burden of disease. The combined insult of HIV infection, heavy alcohol consumption and toxic effects of antiretroviral therapy in aging PLWH poses a public health challenge t hrough incre...
Source: Alcohol and Alcoholism - March 13, 2018 Category: Addiction Source Type: research
A Life Course Approach to Understanding Racial/Ethnic Differences in Transitions Into and Out of Alcohol Problems
ConclusionsWhile Whites appear to ‘age out’ of alcohol problems in their 30s, Blacks are at greater risk after young adulthood. These findings signal a need for interventions that target racial/ethnic minorities beyond young adulthood. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - March 13, 2018 Category: Addiction Source Type: research
Confusion in Sobriety: A Case Study on Disulfiram Encephalopathy in a Middle-Aged Male Patient
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - March 13, 2018 Category: Addiction Source Type: research
The Medical Council on Alcohol ’s 50th Anniversary Witness Seminar
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - March 3, 2018 Category: Addiction Source Type: research
Evaluating Within-Person Change in Implicit Measures of Alcohol Associations: Increases in Alcohol Associations Predict Increases in Drinking Risk and Vice Versa
ConclusionResults from this study indicate bi-directional relationships between increases in alcohol associations (drinking identity, alcohol excite and alcohol approach) and subsequent increases in drinking risk. Intervention and prevention efforts may benefit from targeting these associations. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - March 1, 2018 Category: Addiction Source Type: research
Chinese Women ’s Drinking Patterns Before and After the Hong Kong Alcohol Policy Changes
ConclusionsIncreased drinking among certain subgroups of Hong Kong Chinese women may be due to combined influences of: increased societal acceptance of social drinking, aggressive marketing promotions and personal beliefs in the health benefits of drinking that have recently emerged in the region. Hence, multi-prong strategies are required to combat potential drinking harms in these women. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 23, 2018 Category: Addiction Source Type: research
PNPLA3 Association with Alcoholic Liver Disease in a Cohort of Heavy Drinkers
ConclusionOur case-control study confirmed thatPNPLA3 rs738409 SNP is associated with ALD. This is an important replication in a US clinical sample with control subjects who had long histories of alcohol consumption. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 21, 2018 Category: Addiction Source Type: research
Reply: Carbohydrate Deficient Transferrin in Patients with Cirrhosis: A Tale of Bridges
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 15, 2018 Category: Addiction Source Type: research
Carbohydrate Deficient Transferrin in Patients with Cirrhosis: A Tale of Bridges
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 15, 2018 Category: Addiction Source Type: research
Corrigendum: Alcohol Use in Adolescence and Later Working Memory: Findings From a Large Population-Based Birth Cohort
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 13, 2018 Category: Addiction Source Type: research
Survey Estimates of Changes in Alcohol Use Patterns Following the 2012 Privatization of the Washington Liquor Monopoly
ConclusionsThese findings accurately mirror the overall flat trend in per capita alcohol sales but seem to exaggerate the very small shift towards beer seen in sales data. Effects of increased spirits availability appear to have been countered by increased spirits prices and a decreased beer tax, leading to a shift to beer consumption.Short summarySurvey-based analyses of alcohol use across Washington ’s spirits privatization, beer tax reduction and marijuana legalization found no change in alcohol volume, a reduction in spirits volume and a shift to more moderate drinking patterns. Reductions in drinking occurred among ...
Source: Alcohol and Alcoholism - February 8, 2018 Category: Addiction Source Type: research
Association Analysis Between Genetic Variation in GATA Binding Protein 4 (GATA4) and Alcohol Use Disorder
ConclusionsAlthough previous studies have shown a relationship between variants of theGATA4 gene and a diagnosis of AUD, we did not replicate these findings in our sample. Additional studies of variation in this gene are needed to elucidate whether polymorphisms of theGATA4 gene are associated with AUD and other alcohol-related phenotypes.Short SummaryGATA4 variants were not associated with AUD in either the European ancestry or African ancestry groups after correcting for multiple comparisons. Rs10112596 demonstrated a significant relationship with an anxiety measure among the African ancestry group with AUD. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - February 5, 2018 Category: Addiction Source Type: research
Patient Satisfaction as a Moderator of Risky Alcohol Consumers ’ Attitude Towards Screening and Brief Intervention: A Cross Sectional Survey
ConclusionsRisky consumers show a more positive attitude towards SBI when they are satisfied with their GP. Our results thus suggest the use of a supportive consultation style for the intervention of risky consumers.Short SummarySBI attitude of general practice patients depends on their drinking status: abstainers or low-level consumers revealed a more positive attitude towards SBI than risky consumers. This effect is moderated by the patient ’s satisfaction. Risky consumers show a more positive attitude towards SBI if they are satisfied with their GP. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - January 25, 2018 Category: Addiction Source Type: research
Introduction to the Special Issue on Alcohol and Liver Transplantation
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - January 25, 2018 Category: Addiction Source Type: research
Transplanting Patients with Alcohol-related Liver Disease in the National Health System: New Rules and Decisions
ConclusionLiver transplantation for ArLD is well established in the UK. Recent organizational changes seek to reduce inequities in access to transplant services.Short SummaryLiver disease in the UK is reaching epidemic proportions. Concerns over equity of access to liver transplantation prompted revision of the UK listing criteria for alcohol-associated liver disease in 2016, to improve to the availability of tertiary hepatology services.Transplanting patients with alcohol-related liver disease in the National Health System: New Rules and Decisions‘…The second property of your excellent sherris is, the warming of the b...
Source: Alcohol and Alcoholism - January 23, 2018 Category: Addiction Source Type: research
