Thrombocytopenia in Patients Hospitalized for Alcohol Withdrawal Syndrome and Its Associations to Clinical Complications
ConclusionsThe study demonstrates that patients with AWS and TP (in particular<119k/mL) are at higher risk of developing cAWS. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - August 12, 2019 Category: Addiction Source Type: research
Alcohol Use Disorder and Comorbid Depression: A Randomized Controlled Trial Investigating the Effectiveness of Supportive Text Messages in Aiding Recovery
ConclusionsSupportive text messages provide an early initial benefit in decreasing symptoms of depression and stress, with a further positive impact on alcohol consumption following a longer treatment period. Benefits did not persist six months after the intervention ended. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - July 30, 2019 Category: Addiction Source Type: research
Inhibition of Endoplasmic Reticulum Stress Attenuated Ethanol-Induced Exosomal miR-122 and Acute Liver Injury in Mice
ConclusionsThese findings suggest that ER stress inhibitor PBA attenuated ethanol induced acute liver injury and serum exosomal miR-122, and provides a potential therapy strategy for acute alcoholic liver injury. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - July 30, 2019 Category: Addiction Source Type: research
Cerebral Metabolites on the Descending Limb of Acute Alcohol: A Preliminary 1H MRS Study
ConclusionsThis study offers preliminary evidence of alcohol-related increases in Glx/Cr, Cho/Cr and GSH/Cr on the descending limb of blood alcohol concentration. Findings add novel information to previous research on neurometabolic changes at peak blood alcohol in healthy individuals and during withdrawal in individuals with alcohol use disorder. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - July 19, 2019 Category: Addiction Source Type: research
Chronic Binge Alcohol-Associated Differential Brain Region Modulation of Growth Factor Signaling Pathways and Neuroinflammation in Simian Immunodeficiency Virus-Infected Male Macaques
ConclusionsCBA differentially affects growth factor and inflammatory cytokine expression and viral load across brain regions. In the PFC, suppression of growth factor signaling may be an important neuropathological mechanism, while inflammatory processes may play a more important role in the CD and HP. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - July 19, 2019 Category: Addiction Source Type: research
Carbohydrate-deficient transferrin: utility of HPLC in handling atypical samples uninterpretable by capillary electrophoresis
ConclusionsSecond-line HPLC testing reduced uninterpretable samples by 47%, with similar rates of improvement regardless of the type of CDT pattern. The usefulness of HPLC as a second-line test for CDT should be evaluated according to cost-benefit considerations in the context of each laboratory. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - July 11, 2019 Category: Addiction Source Type: research
Correlates of Reduced Alcohol Consumption among a Sample of Young Australians
ConclusionsRecent reduction in alcohol consumption was common among young people in this study. Recent reduction in alcohol consumption was common among young people in this study. A combination of factors appear to be correlated with recent attempts to reduce drinking young people including socio-demographic characteristics, religiosity, drinking practices and experience of harm, and interest in health. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 28, 2019 Category: Addiction Source Type: research
Burden of Alcohol Disorders on Emergency Department Attendances and Hospital Admissions in England
ConclusionsAD place a disproportionate impact on hospital services with CAD exerting the greatest burden on hospital utilization. The complexity and burden of CAD suggests this group should be a priority for intervention. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 28, 2019 Category: Addiction Source Type: research
Erratum: Timeline Followback Self-Reports Underestimate Alcohol Use Prior to Successful Contingency Management Treatment
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 25, 2019 Category: Addiction Source Type: research
‘Mother’s Ruin’—Why Sex and Gender Differences in the Field of Alcohol Research Need Consideration
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 25, 2019 Category: Addiction Source Type: research
Antabuse Treatment for Alcoholism
, by BrewerC and StreelE (2018). 276pp, paperback, CreateSpace. ISBN: 9781977929228 (Available from Amazon Books at about 16 euros, less for Kindle version) (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 20, 2019 Category: Addiction Source Type: research
Alcoholic Hepatitis: A Review
AbstractAlcoholic liver disease (ALD) represents a spectrum of injury, ranging from simple steatosis to alcoholic hepatitis to cirrhosis. Regular alcohol use results in fatty changes in the liver which can develop into inflammation, fibrosis and ultimately cirrhosis with continued, excessive drinking. Alcoholic hepatitis (AH) is an acute hepatic inflammation associated with significant morbidity and mortality that can occur in patients with steatosis or underlying cirrhosis. The pathogenesis of ALD is multifactorial and in addition to genetic factors, alcohol-induced hepatocyte damage, reactive oxygen species, gut-derived ...
Source: Alcohol and Alcoholism - June 20, 2019 Category: Addiction Source Type: research
Sex Differences in Value-Based Decision Making Underlie Substance Use Disorders in Females
(Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 20, 2019 Category: Addiction Source Type: research
Mental Health and Affect Regulation Impairment in Fetal Alcohol Spectrum Disorder (FASD): Results from the Canadian National FASD Database
ConclusionAR impairment is strongly related to several mental health diagnoses in those with FASD and presents some promising possibilities for targeted early intervention. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 19, 2019 Category: Addiction Source Type: research
Lack of Association between Opioid-Receptor Genotypes and Smoking Cessation Outcomes in a Randomized, Controlled Naltrexone Trial
ConclusionsIn sum, these results do not suggest that genetic variation in opioid-receptors is related to treatment responses to naltrexone in a smoking cessation trial. (Source: Alcohol and Alcoholism)
Source: Alcohol and Alcoholism - June 17, 2019 Category: Addiction Source Type: research
