Associations of healthy aging index and all-cause and cause-specific mortality: a prospective cohort study of UK Biobank participants
AbstractThe healthy aging index (HAI) has been recently developed as a surrogate measure of biological age. However, to what extent the HAI is associated with all-cause and cause-specific mortality and whether this association differs in younger and older adults remains unknown. We aimed to quantify the association between the HAI and mortality in a population of UK adults. In the prospective cohort study, data are obtained from the UK Biobank. Five HAI components (systolic blood pressure, reaction time, cystatin C, serum glucose, forced vital capacity) were scored 0 (healthiest), 1, and 2 (unhealthiest) according to sex-s...
Source: AGE - August 1, 2023 Category: Geriatrics Source Type: research
Associations of sugar-sweetened, artificially sweetened, and naturally sweet juices with Alzheimer ’s disease: a prospective cohort study
AbstractEpidemiological studies of sugar-sweetened beverages (SSBs) and artificially sweetened beverages (ASBs) with Alzheimer ’s disease (AD) have provided controversial findings. Furthermore, little is known about the association between pure fruit/vegetable juices and AD. The present study aims to estimate the associations of SSBs, ASBs, and pure fruit/vegetable juices with AD, and to evaluate the theoretical effects o f replacing SSBs and ASBs with the different consumption of pure fruit/vegetable juices on the risk of AD. This prospective cohort study of the UK Biobank included 206,606 participants aged 39–72 yea...
Source: AGE - August 1, 2023 Category: Geriatrics Source Type: research
Utilizing multimodal approach to identify candidate pathways and biomarkers and predicting frailty syndrome in individuals from UK Biobank
This study provides novel insights into increased vulnerability and risk stratification of frailty syndrome via a multi-modal approach. The findings suggest frailty as a highly polygenic-trait, enriched in cholesterol-remodeling and metabolism and to be genetically associated with cognitive abilities. ML models utilizing FP and FI + PRS were established that identified frailty-syndrome patients with high accuracy. (Source: AGE)
Source: AGE - July 31, 2023 Category: Geriatrics Source Type: research
Associations between physical exercise type, fluid intelligence, executive function, and processing speed in the oldest-old (85 +)
ConclusionsOur findings suggest self-reported exercise in the oldest-old is linked to better performance on cognitive measures of processing speed and executive functioning, and that there may be a synergistic effect of combining aerobic and resistance training on cognition. (Source: AGE)
Source: AGE - July 31, 2023 Category: Geriatrics Source Type: research
Prefrontal hemodynamic features of older adults with preserved visuospatial working memory function
Abstract
Memory decline has been observed in the aging population and is a risk factor for the later development of dementia. Understanding how memory is preserved in older adults has been an important topic. The present study examines the hemodynamic features of older adults whose memory is comparable with that of young adults. In the present study, 45 younger and 45 older adults performed the visual memory task with various difficulty levels (i.e., the items to be remembered), and their cerebral hemodynamics at each level were measured by functional near-infrared spectroscopy (fNIRS). The results showed that older adu...
Source: AGE - July 27, 2023 Category: Geriatrics Source Type: research
