Vascular senescence and leak are features of the early breakdown of the blood –brain barrier in Alzheimer’s disease models
AbstractAlzheimer ’s disease (AD) is an age-related disease, with loss of integrity of the blood–brain barrier (BBB) being an early feature. Cellular senescence is one of the reported nine hallmarks of aging. Here, we show for the first time the presence of senescent cells in the vasculature in AD patients and mo use models of AD. Senescent endothelial cells and pericytes are present in APP/PS1 transgenic mice but not in wild-type littermates at the time of amyloid deposition. In vitro, senescent endothelial cells display altered VE-cadherin expression and loss of cell junction formation and increased permea bility. Co...
Source: AGE - November 28, 2023 Category: Geriatrics Source Type: research
Whole brain irradiation –induced endothelial dysfunction in the mouse brain
AbstractWhole brain irradiation (WBI), also known as whole brain radiation therapy (WBRT), is a well-established treatment for multiple brain metastases and as a preventive measure to reduce the risk of recurrence after surgical removal of a cerebral metastasis. However, WBI has been found to lead to a gradual decline in neurocognitive function in approximately 50% of patients who survive the treatment, significantly impacting their overall quality of life. Recent preclinical investigations have shed light on the underlying mechanisms of this adverse effect, revealing a complex cerebrovascular injury that involves the indu...
Source: AGE - November 13, 2023 Category: Geriatrics Source Type: research
Reduction in metabolic noise reveals rejuvenation following transient severe caloric restriction
AbstractAmong land vertebrates, the laying hen stands out due to its great reproductive efficiency: producing an egg daily all year long. This production rate makes the laying hen a special model animal to study the general process of reproduction and aging. One unique aspect of hens is their ability to undergo reproductive plasticity and to rejuvenate their reproductive tract during molting, a standard industrial feed restriction protocol for transiently pausing reproduction, followed by improved laying efficiency almost to peak production. Here we use longitudinal metabolomics, immunology, and physiological assays to sho...
Source: AGE - November 10, 2023 Category: Geriatrics Source Type: research
Murine cartilage microbial DNA deposition occurs rapidly following the introduction of a gut microbiome and changes with obesity, aging, and knee osteoarthritis
In conclusion, cartilage microbial DNA patterns develop rapidly after the introduction of a gut microbiome and change in concert with the gut microbiome during aging, HFD, and OA in mice. DMM-induced OA causes shifts in both cartilage and cecal microbiome patterns independent of other factors. (Source: AGE)
Source: AGE - November 9, 2023 Category: Geriatrics Source Type: research
Lateralized brunt of sleep deprivation on white matter injury in a rat model of Alzheimer ’s disease
AbstractSleep disturbance is a recognized risk factor for Alzheimer ’s disease (AD), but the underlying micro-pathological evidence remains limited. To bridge this gap, we established an amyloid-β oligomers (AβO)-induced rat model of AD and subjected it to intermittent sleep deprivation (SD). Diffusion tensor imaging (DTI) and transmission electron microscopy we re employed to assess white matter (WM) integrity and ultrastructural changes in myelin sheaths. Our findings demonstrated that SD exacerbated AβO-induced cognitive decline. Furthermore, we found SD aggravated AβO-induced asymmetrical impairments in WM, prese...
Source: AGE - November 9, 2023 Category: Geriatrics Source Type: research
Aerobic exercise training effects on hippocampal volume in healthy older individuals: a meta-analysis of randomized controlled trials
AbstractWe conducted a meta-analysis of randomized controlled trials investigating the effects of aerobic exercise training (AET) lasting ≥ 4 weeks on hippocampal volume and cardiorespiratory fitness (CRF) in cognitively unimpaired, healthy older individuals. Random-effects robust variance estimation models were used to test differences between AET and controls, while meta-regressions tested associations between CRF and hippoc ampal volume changes. We included eight studies (N = 554) delivering fully supervised AET for 3 to 12 months (M = 7.8, SD = 4.5) with an average AET volume of 129.85 min/week (S...
Source: AGE - November 9, 2023 Category: Geriatrics Source Type: research
Comparative biology and non-traditional approaches for basic aging research for facilitating translational studies
AbstractAs humans, we aspire to healthy aging and ideally reaching our maximal lifespan. That, however, requires optimizing resilience to stressors and minimizing exposure to factors that accelerate aging. Understanding the complexities of aging processes involves characterizing the causal bases of physical, physiological, and cognitive deficits that accumulate over time, eventually culminating in reduced functionality and decreased resistance to disease and environmental stressors. Both the progression of age-related conditions and onset of diseases are affected by environmental stressors; however, the basis for increased...
Source: AGE - November 9, 2023 Category: Geriatrics Source Type: research
Rapid measurement of ageing by automated monitoring of movement of C. elegans populations
AbstractFinding new interventions that slow ageing and maintain human health is a huge challenge of our time. The nematodeCaenorhabditis elegans offers a rapid in vivo method to determine whether a compound extends its 2 to 3-week lifespan. Measuring lifespan is the standard method to monitor ageing, but a compound that extends lifespan will not necessarily maintain health. Here, we describe the automated monitoring ofC. elegans movement from early to mid-adulthood as a faster healthspan-based method to measure ageing. Using the WormGazer ™ technology, multiple Petri dishes each containing severalC. elegans worms are ima...
Source: AGE - November 8, 2023 Category: Geriatrics Source Type: research
Socioeconomic status, lifestyle and risk of incident dementia: a prospective cohort study of 276730 participants
This study aimed to detect the joint and interactive associations of socioeconomic status (SES) and lifestyle factors with incident dementia risk, and the underlying brain imaging alterations. Cox proportional hazards analysis was performed to test the joint and interactive associations. Partial correlation analysis was performed to reflect the brain imaging alterations. A total of 276,730 participants with a mean age of 55.9 ( ±8.0) years old from UK biobank were included. Over 8.5 (±2.6) years of follow-up, 3013 participants were diagnosed with dementia. Participants with high SES and most healthy lifestyle had a signi...
Source: AGE - November 6, 2023 Category: Geriatrics Source Type: research
Correction to: Old plasma dilution reduces human biological age: a clinical study
(Source: AGE)
Source: AGE - November 6, 2023 Category: Geriatrics Source Type: research
ATAC-clock: An aging clock based on chromatin accessibility
In conclusion, we demonstrate that the clock relies on cell-intrinsic chromatin accessibility alterations rather than changes in cell composition. Further, we present a new approach to construct epigenetic aging clocks based on chromatin accessibility, which bear a direc t link to age-related transcriptional alterations, but which allow for more accurate age predictions than transcriptomic clocks. (Source: AGE)
Source: AGE - November 4, 2023 Category: Geriatrics Source Type: research
Antioxidants green tea extract and nordihydroguaiaretic acid confer species and strain-specific lifespan and health effects in Caenorhabditis nematodes
AbstractTheCaenorhabditis Intervention Testing Program (CITP) is an NIH-funded research consortium of investigators who conduct analyses at three independent sites to identify chemical interventions that reproducibly promote health and lifespan in a robust manner. The founding principle of the CITP is that compounds with positive effects across a genetically diverse panel ofCaenorhabditis species and strains are likely engaging conserved biochemical pathways to exert their effects. As such, interventions that are broadly efficacious might be considered prominent compounds for translation for pre-clinical research and human...
Source: AGE - November 4, 2023 Category: Geriatrics Source Type: research
A network-based approach to explore comorbidity patterns among community-dwelling older adults living alone
This study employed a network-based approach to investigate the comorbidity patterns of community-dwelling older adults living alone. The sample comprised a cross-sectional cohort of adults 65 or older living alone in a Korean city (n = 1041; mean age = 77.7 years, 77.6% women). A comorbidity network analysis that estimates networks aggregated from measures of significant co-occurrence between pairs of diseases was employed to investigate comorbid associations between 31 chronic conditions. A cluster detection algorithm was employed to identify specific clusters of comorbidities. The association strength was expre...
Source: AGE - November 4, 2023 Category: Geriatrics Source Type: research
Correction to: Blood biomarker profiles and exceptional longevity: comparison of centenarians and non ‑centenarians in a 35‑year follow‑up of the Swedish AMORIS cohort
(Source: AGE)
Source: AGE - November 4, 2023 Category: Geriatrics Source Type: research
Correction to: Higher testosterone and testosterone/estradiol ratio in men are associated with decreased Pheno ‑/GrimAge and DNA‑methylation based PAI1
(Source: AGE)
Source: AGE - November 3, 2023 Category: Geriatrics Source Type: research
