Early neurological changes in aging cervical spine: insights from PROMIS mobility assessment
In this study, 51 DCM patients and 42 age-matched healthy control (HC) were enrolled. The degree of cervical spinal cord compression was assessed using the high-resolution cervical spinal cord T2 Weighted (T2w) MRIs, which were available for 14 DCM patients. Measurements of the spinal cords anterior –posterior (AP) diameter at the region(s) that were visibly compressed as well as at different cervical spine levels were used to determine the degree of compression. The age-matched HC cohort had a similar MRI to establish the normal range for AP diameter. Twelve (12) participants in the HC cohor t had MRI evidence of cervic...
Source: AGE - January 10, 2024 Category: Geriatrics Source Type: research
Factors influencing gait performance in older adults in a dual-task paradigm
AbstractThe aim of this study was to determine the effect of cognitive interference through a dual-task (DT) paradigm on gait parameters by sex or other predictive variables, such as physical fitness, health status, and cognition. A total of 125 older adults joined in this study (age, 72.42 ± 5.56 years old; 28 men and 97 women). The DT paradigm was evaluated through Comfortable Linear Gait (CLG) and Complex Gait Test (CGT). The gait parameters between single task (ST) vs. DT condition in men showed a significant reduction in speed (p < 0.001), cadence (p < 0.001), and step length (p = 0.049) and i...
Source: AGE - January 8, 2024 Category: Geriatrics Source Type: research
The interplay of aging, adipose tissue, and COVID-19: a potent alliance with implications for health
AbstractObesity has emerged as a significant public health challenge. With the ongoing increase in life expectancy, the prevalence of obesity is steadily growing, particularly among older age demographics. The extension of life expectancy frequently results in additional years of vulnerability to chronic health issues associated with obesity in the elderly.The concept of SARS-CoV-2 directly infecting adipose tissue stems from the fact that both adipocytes and stromal vascular fraction cells express ACE2, the primary receptor facilitating SARS-CoV-2 entry. It is noteworthy that adipose tissue demonstrates ACE2 expression le...
Source: AGE - January 8, 2024 Category: Geriatrics Source Type: research
Fisetin modulates the gut microbiota alongside biomarkers of senescence and inflammation in a DSS-induced murine model of colitis
AbstractColitis, a subtype of inflammatory bowel disease (IBD), is a multifactorial disorder characterized by chronic inflammation of the colon. Among various experimental models used in the study of IBD, the chemical colitogenic dextran sulfate sodium (DSS) is most commonly employed to induce colitis in vivo. In the search for new therapeutic strategies, Fisetin, a flavonoid found in many fruits and vegetables, has recently garnered attention for its senolytic properties. Female mice were administered 2.5% DSS in sterile drinking water and were subsequently treated with Fisetin or vehicle by oral gavage. DSS significantly...
Source: AGE - January 8, 2024 Category: Geriatrics Source Type: research
Irradiation-induced hair graying in mice: an experimental model to evaluate the effectiveness of interventions targeting oxidative stress, DNA damage prevention, and cellular senescence
AbstractHair graying, also known as canities or achromotrichia, is a natural phenomenon associated with aging and is influenced by external factors such as stress, environmental toxicants, and radiation exposure. Understanding the mechanisms underlying hair graying is an ideal approach for developing interventions to prevent or reverse age-related changes in regenerative tissues. Hair graying induced by ionizing radiation ( γ-rays or X-rays) has emerged as a valuable experimental model to investigate the molecular pathways involved in this process. In this review, we examine the existing evidence on radiation-induced hair...
Source: AGE - January 6, 2024 Category: Geriatrics Source Type: research
Neutrophil, lymphocyte count, and neutrophil to lymphocyte ratio predict multimorbidity and mortality —results from the Baltimore Longitudinal Study on Aging follow-up study
In conclusion, this stu dy supports the importance of the NL ratio and absolute neutrophil count as markers of aging health status, and as significant predictors of all-cause mortality and multimorbidity in aging individuals. It remains to be demonstrated whether interventions contrasting these trends in circulating cells may result in improved health outcomes. (Source: AGE)
Source: AGE - January 6, 2024 Category: Geriatrics Source Type: research
Prognostic accuracy of 70 individual frailty biomarkers in predicting mortality in the Canadian Longitudinal Study on Aging
AbstractThe frailty index (FI) uses a deficit accumulation approach to derive a single, comprehensive, and replicable indicator of age-related health status. Yet, many researchers continue to seek a single “frailty biomarker” to facilitate clinical screening. We investigated the prognostic accuracy of 70 individual biomarkers in predicting mortality, comparing each with a composite FI. A total of 29,341 individuals from the comprehensive cohort of the Canadian Longitudinal Study on Aging were incl uded (mean, 59.4 ± 9.9 years; 50.3% female). Twenty-three blood-based biomarkers and 47 test-based biomarkers (e.g., ...
Source: AGE - January 6, 2024 Category: Geriatrics Source Type: research
Titan mice as a model to test interventions that attenuate frailty and increase longevity
AbstractWild-type murine models for aging research have lifespans of several years, which results in long experimental duration and late output. Here we explore the short-lived non-inbred Titan mouse (DU6) as a mouse model to test longevity interventions. We show that Titan mice exhibit increased frailty and senescence-associated beta-galactosidase activity at an early age. Dietary intervention attenuates the frailty progression of Titan mice. Additionally, cyclic administration of the senolytic drug Navitoclax at an early age increases the lifespan and reduces senescence-associated beta-galactosidase activity. Our data su...
Source: AGE - January 5, 2024 Category: Geriatrics Source Type: research
Baseline and usual triglyceride-glucose index and the risk of chronic kidney disease: a prospective cohort study
AbstractTriglyceride-glucose (TyG) index is an emerging marker of adverse cardiometabolic conditions such as cardiovascular disease and type 2 diabetes. The long-term relevance of TyG index to chronic kidney disease (CKD) is uncertain. We aimed to assess the association of TyG index with CKD risk and its utility in risk prediction in a prospective study. The TyG index was calculated using fasting triglycerides and fasting plasma glucose (FPG) levels measured in 2362 men aged 42 –61 years with normal kidney function using the formula: Ln (fasting triglycerides [mg/dL] × FPG [mg/dL]/2). Multivariable adjusted hazard ratio...
Source: AGE - January 5, 2024 Category: Geriatrics Source Type: research
Modulation of movement-related oscillatory signatures by cognitive interference in healthy aging
AbstractAge-related changes in the neurophysiology underlying motor control are well documented, but whether these changes are specific to motor function or more broadly reflect age-related alterations in fronto-parietal circuitry serving attention and other higher-level processes remains unknown. Herein, we collected high-density magnetoencephalography (MEG) in 72 healthy adults (age 28 –63 years) as they completed an adapted version of the multi-source interference task that involved two subtypes of cognitive interference (i.e., flanker and Simon) and their integration (i.e., multi-source). All MEG data were examined ...
Source: AGE - January 4, 2024 Category: Geriatrics Source Type: research
Cell Tree Rings: the structure of somatic evolution as a human aging timer
AbstractBiological age is typically estimated using biomarkers whose states have been observed to correlate with chronological age. A persistent limitation of such aging clocks is that it is difficult to establish how the biomarker states are related to the mechanisms of aging. Somatic mutations could potentially form the basis for a more fundamental aging clock since the mutations are both markers and drivers of aging and have a natural timescale. Cell lineage trees inferred from these mutations reflect the somatic evolutionary process, and thus, it has been conjectured, the aging status of the body. Such a timer has been...
Source: AGE - January 4, 2024 Category: Geriatrics Source Type: research
Longitudinal changes in the functional connectivity of individuals at risk of Alzheimer ’s disease
This study consolidates the use of electrophysiology, in combi nation with plasma biomarkers, to monitor healthy individuals at risk of Alzheimer’s disease and emphasizes the value of combining noninvasive markers to understand the underlying mechanisms and track disease progression. This could facilitate the design of more effective intervention strategies a nd accurate progression assessment tools. (Source: AGE)
Source: AGE - January 4, 2024 Category: Geriatrics Source Type: research
Intracellular iron accumulation facilitates mycobacterial infection in old mouse macrophages
In this study, we investigated the response of bone marrow –derived macrophage (BMMs) isolated from young (5 months) and old (25 months) mice toM. avium serotype 4, one of the main NTM species in patients with pulmonary NTM diseases. Our results demonstrated that BMMs from old mice have an increased level of intracellular iron and are more susceptible toM. avium serotype 4 infection compared to BMMs from young mice. The whole-cell proteomic analysis indicated a dysregulated expression of iron homeostasis –associated proteins in old BMMs regardless of mycobacterial infection. Deferoxamine, an iron chelator, significan...
Source: AGE - December 30, 2023 Category: Geriatrics Source Type: research
Tobacco exposure, but not aging, shifts the frequency of peripheral blood B cell subpopulations
AbstractSeveral disturbances in T-cell mediated immunity have been described during aging, but immunosenescence of the B-cell compartment is less well elucidated. The peripheral blood B-cell compartment (CD19+) can be split into six main subpopulations according to the cell surface markers IgD, CD27, CD24, and CD38: Transitional, na ïve, unswitched, switched, double negative and plasmablasts. We thus aimed to verify whether shifts in these subsets occur during healthy and pathological aging. We recruited three groups of aged people (> 60 years old), healthy, COPD patients, and smokers without altered pulmonary function...
Source: AGE - December 29, 2023 Category: Geriatrics Source Type: research
PEDF protects retinal pigment epithelium from ferroptosis and ameliorates dry AMD-like pathology in a murine model
This study revealed the novel role of PEDF in ferroptosis inhibition and indicated that PEDF might be a potential therapeutic target for dry AMD. (Source: AGE)
Source: AGE - December 28, 2023 Category: Geriatrics Source Type: research
