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High-fat diet, but not duration of lactation, increases mammary gland lymphatic vessel function and subsequent growth of inflammatory breast cancer cells
AbstractInflammatory breast cancer (IBC) presents as rapid-onset swelling and breast skin changes caused by tumor emboli in the breast and breast skin lymphatics. IBC has been linked with obesity and duration of breastfeeding, but how these factors affect IBC tumor progression is not clear. We modeled the simultaneous effects of diet and weaning in mice on in vivo lymphatic function; on IBC tumor growth; and on aspects of the mammary gland microenvironment before and after IBC (SUM149) xenograft inoculation. We hypothesized that weaning status and diet would have synergistic effects on lymphatic function and the breast mic...
Source: Journal of Mammary Gland Biology and Neoplasia - October 6, 2023 Category: Cancer & Oncology Source Type: research

Risk factors of breast cancer recurrence in pathologic complete response achieved by patients following neoadjuvant chemotherapy: a single-center retrospective study
ConclusionResults in this study showed that clinical T, clinical N stage, and molecular subtypes were not statistically significant predictors of recurrence in patients who achieved pCR after NAC. In spite of that, pCR after NAC may be more important than clinical staging and molecular subtype in early breast cancer. In addition, escalated treatments for patients with HER2 + or triple-negative tumors would be considered with a strict patient selection strategy to prevent over-treatment as well as achieve pCR. (Source: Frontiers in Oncology)
Source: Frontiers in Oncology - October 2, 2023 Category: Cancer & Oncology Source Type: research

Engineering E2 Bionanoparticles for Targeted Delivery of Chemotherapeutics to Breast Cancer Cells
Methods Mol Biol. 2024;2720:177-189. doi: 10.1007/978-1-0716-3469-1_13.ABSTRACTNaturally occurring protein nanocages are promising drug carriers as both the interior and exterior can be decorated for drug encapsulation and cell targeting. To provide surface functionalization, we added a SpyTag to E2 nanocages (ST-E2) to enable tunable decoration using the robust SpyCatcher bioconjugation strategy. Additionally, the E2 core was mutated with four phenylalanine substitutions for doxorubicin loading and pH-responsive release. By decorating the exterior with a highly cell-specific epidermal growth factor receptor (EGFR)-targeti...
Source: Mol Biol Cell - September 29, 2023 Category: Molecular Biology Authors: Millicent O Sullivan Wilfred Chen Source Type: research

Engineering Hepatitis B Virus (HBV) Protein Particles for Therapeutic Delivery
Methods Mol Biol. 2024;2720:115-126. doi: 10.1007/978-1-0716-3469-1_8.ABSTRACTNature provides an abundance of proteins whose structures and reactivity have been perfected through evolution to perform specific tasks necessary for biological function. The structural and functional properties of many natural proteins are quite valuable for the construction and customization of drug delivery vehicles. Self-assembling protein nanoparticle platforms are particularly useful scaffolds, as their multi-subunit designs allow the attachment of a high density of modifying molecules such as cell-binding ligands that provide avidity for ...
Source: Mol Biol Cell - September 29, 2023 Category: Molecular Biology Authors: Millicent O Sullivan Wilfred Chen Source Type: research

Expert UK consensus on the definition of high risk of recurrence in HER2-negative early breast cancer: A modified Delphi panel
CONCLUSIONS: The results may be a valuable reference point to guide recurrence risk assessment and decision-making after surgery in the HER2-negative eBC population.PMID:37769521 | DOI:10.1016/j.breast.2023.103582 (Source: Breast)
Source: Breast - September 28, 2023 Category: Cancer & Oncology Authors: E R Copson J E Abraham J P Braybrooke D Cameron S A McIntosh C O Michie A F C Okines C Palmieri F Raja R Roylance S Spensley Delphi panellists Source Type: research

Expert UK consensus on the definition of high risk of recurrence in HER2-negative early breast cancer: A modified Delphi panel
CONCLUSIONS: The results may be a valuable reference point to guide recurrence risk assessment and decision-making after surgery in the HER2-negative eBC population.PMID:37769521 | PMC:PMC10539921 | DOI:10.1016/j.breast.2023.103582 (Source: Breast)
Source: Breast - September 28, 2023 Category: Cancer & Oncology Authors: E R Copson J E Abraham J P Braybrooke D Cameron S A McIntosh C O Michie A F C Okines C Palmieri F Raja R Roylance S Spensley Delphi panellists Source Type: research

Cancers, Vol. 15, Pages 4597: Improved Rate of Negative Margins for Inflammatory Breast Cancer Using Intraoperative Frozen Section Analysis
Conclusions: The FSA technique decreased the number of positive margins in IBC patients undergoing MRM, thereby potentially reducing the need for re-operation, allowing immediate wound closure, and preventing delays in the administration of adjuvant radiation therapy. More extensive trials are warranted to establish the use of intraoperative FSA in IBC treatment. (Source: Cancers)
Source: Cancers - September 16, 2023 Category: Cancer & Oncology Authors: Joshua Kong Sudeshna Bandyopadhyay Wei Chen Faisal Al-Mufarrej Lydia Choi Mary A. Kosir Tags: Communication Source Type: research

ASO Visual Abstract: Low Rates of Local-Regional Recurrence in Inflammatory Breast Cancer Patients After Contemporary Trimodal Therapy
(Source: Annals of Surgical Oncology)
Source: Annals of Surgical Oncology - September 11, 2023 Category: Cancer & Oncology Source Type: research

ASO Author Reflections: Low Rates of Local-Regional Recurrence in Inflammatory Breast Cancer Patients After Contemporary Trimodal Therapy
Ann Surg Oncol. 2023 Aug 23. doi: 10.1245/s10434-023-14159-y. Online ahead of print.NO ABSTRACTPMID:37610486 | DOI:10.1245/s10434-023-14159-y (Source: Ann Oncol)
Source: Ann Oncol - August 23, 2023 Category: Cancer & Oncology Authors: Taiwo Adesoye Anthony Lucci Source Type: research

ASO Visual Abstract: Low Rates of Local-Regional Recurrence in Inflammatory Breast Cancer Patients After Contemporary Trimodal Therapy
Ann Surg Oncol. 2023 Aug 14. doi: 10.1245/s10434-023-14066-2. Online ahead of print.NO ABSTRACTPMID:37578608 | DOI:10.1245/s10434-023-14066-2 (Source: Ann Oncol)
Source: Ann Oncol - August 14, 2023 Category: Cancer & Oncology Authors: Taiwo Adesoye Shlermine Everidge Jennifer Chen Susie X Sun Mediget Teshome Vicente Valero Wendy A Woodward Anthony Lucci Source Type: research