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Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models
Int Rev Cell Mol Biol. 2024;384:77-112. doi: 10.1016/bs.ircmb.2023.10.006. Epub 2024 Feb 10.ABSTRACTInflammatory breast cancer is an aggressive subtype of breast cancer with dismal patient prognosis and a unique clinical presentation. In the past two decades, molecular profiling technologies have been used in order to gain insight into the molecular biology of IBC and to search for possible targets for treatment. Although a gene signature that accurately discriminates between IBC and nIBC patient samples and preclinical models was identified, the overall genomic and transcriptomic differences are small and ambiguous, mainl...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Charlotte Rypens Christophe Van Berckelaer Fedor Berditchevski Peter van Dam Steven Van Laere Source Type: research

Inflammatory breast cancer biomarkers and biology
Int Rev Cell Mol Biol. 2024;384:63-76. doi: 10.1016/bs.ircmb.2023.11.002. Epub 2024 Feb 5.ABSTRACTInflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within the medical community. Early molecular and biological studies incidentally included IBC samples with other conventional breast cancers and were not informative as to...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Kenneth L van Golen Source Type: research

Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research

Radiation for inflammatory breast cancer: Updates
Int Rev Cell Mol Biol. 2024;384:25-46. doi: 10.1016/bs.ircmb.2023.10.004. Epub 2023 Oct 19.ABSTRACTInflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IBC has increased over time, although it still makes up only 1-4% of all breast cancer diagnoses. Despite recent encouraging data on clinical outcomes, the published local-regional control rates remain consistently lower than the rates for non-IBC. In this review, we focus on radiotherapy, pr...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Michael C Stauder Source Type: research

Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research

Advances in targets in inflammatory breast cancer
Int Rev Cell Mol Biol. 2024;384:125-152. doi: 10.1016/bs.ircmb.2023.10.005. Epub 2024 Feb 5.NO ABSTRACTPMID:38637096 | DOI:10.1016/bs.ircmb.2023.10.005 (Source: Mol Biol Cell)
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Toshiaki Iwase Xiaoping Wang Lan Thi Hanh Phi Nithya Sridhar Naoto T Ueno Jangsoon Lee Source Type: research

Inflammatory breast cancer: As surgical oncologists, what can we do?
Int Rev Cell Mol Biol. 2024;384:113-124. doi: 10.1016/bs.ircmb.2024.02.004. Epub 2024 Mar 28.ABSTRACTBreast cancer surgery is the primary treatment for early-stage breast cancer. However, inflammatory breast cancer (IBC), with its specific presentation characterized by skin invasion, is unfit for primary surgery. According to the different guidelines, the management of IBC is trimodal with the coordination of oncologists, surgeons, and radiation therapists. Advances in breast cancer imaging and the development of more targeted therapies make new challenges for this aggressive cancer. This chapter aims to provide an update ...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Hatem Bouzaiene Fatma Saadallah Hanen Bouaziz Olfa Jaidane Jamel Ben Hassouna Tarak Dhieb Khaled Rahal Source Type: research

Inflammatory breast cancer: Epidemiologic data and therapeutic results
In this study, we reviewed the literature using the Surveillance, Epidemiology, and End Results (SEER) database compared to other published series. We observed that in the high incidence areas (North of Africa) when compared to "classical" breast cancer, IBC was associated to younger age (less than 50 years) with rapid evolution of signs and symptoms (in less than 3 up to 6 months), and more aggressive clinical and histopathological-molecular parameters, due to the predominance of triple-negative and HER2+ subtypes in around 60% of cases. An epidemiologic trend was observed in both high and low incidence areas since the ei...
Source: Mol Biol Cell - April 18, 2024 Category: Molecular Biology Authors: Hamouda Boussen Yosra Berrazaga None Sherif Kullab Maroua Manai Narjess Berrada Nesrine Mejri Ismail Siala Paul H Levine Massimo Cristofanilli Source Type: research

Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: Molecular Medicine)
Source: Molecular Medicine - April 18, 2024 Category: Molecular Biology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research

Deciphering the molecular biology of inflammatory breast cancer through molecular characterization of patient samples and preclinical models
Int Rev Cell Mol Biol. 2024;384:77-112. doi: 10.1016/bs.ircmb.2023.10.006. Epub 2024 Feb 10.ABSTRACTInflammatory breast cancer is an aggressive subtype of breast cancer with dismal patient prognosis and a unique clinical presentation. In the past two decades, molecular profiling technologies have been used in order to gain insight into the molecular biology of IBC and to search for possible targets for treatment. Although a gene signature that accurately discriminates between IBC and nIBC patient samples and preclinical models was identified, the overall genomic and transcriptomic differences are small and ambiguous, mainl...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Charlotte Rypens Christophe Van Berckelaer Fedor Berditchevski Peter van Dam Steven Van Laere Source Type: research

Inflammatory breast cancer biomarkers and biology
Int Rev Cell Mol Biol. 2024;384:63-76. doi: 10.1016/bs.ircmb.2023.11.002. Epub 2024 Feb 5.ABSTRACTInflammatory breast cancer (IBC) is a unique breast cancer with a highly virulent course and low 5- and 10-year survival rates. Even though it only accounts for 1-5% of breast cancers it is estimated to account for 10% of breast cancer deaths annually in the United States. The accuracy of diagnosis and classification of this unique cancer is a major concern within the medical community. Early molecular and biological studies incidentally included IBC samples with other conventional breast cancers and were not informative as to...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Kenneth L van Golen Source Type: research

Inflammatory breast cancer: An overview about the histo-pathological aspect and diagnosis
Int Rev Cell Mol Biol. 2024;384:47-61. doi: 10.1016/bs.ircmb.2024.02.001. Epub 2024 Mar 29.ABSTRACTInflammatory Breast Cancer (IBC) is a rare and aggressive form of locally advanced breast cancer, classified as stage T4d according to the tumor-node-metastasis staging criteria. This subtype of breast cancer is known for its rapid progression and significantly lower survival rates compared to other forms of breast cancer. Despite its distinctive clinical features outlined by the World Health Organization, the histopathological characteristics of IBC remain not fully elucidated, presenting challenges in its diagnosis and trea...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Ghada Sahraoui Nabil Rahoui Maha Driss Karima Mrad Source Type: research

Radiation for inflammatory breast cancer: Updates
Int Rev Cell Mol Biol. 2024;384:25-46. doi: 10.1016/bs.ircmb.2023.10.004. Epub 2023 Oct 19.ABSTRACTInflammatory breast cancer (IBC) is a diagnosis based on a constellation of clinical features of edema (peau d'orange) of a third or more of the skin of the breast with a palpable border and a rapid onset of breast erythema. Incidence of IBC has increased over time, although it still makes up only 1-4% of all breast cancer diagnoses. Despite recent encouraging data on clinical outcomes, the published local-regional control rates remain consistently lower than the rates for non-IBC. In this review, we focus on radiotherapy, pr...
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Michael C Stauder Source Type: research

Inflammatory breast cancer (IBC) advocacy-Past, present and future!
In conclusion, in defining the evolving roles of Patient Advocacy in IBC over the past 25 years, we examine what has been done, along with its challenges, and what work still remains from the perspectives of different patient advocates.PMID:38637097 | DOI:10.1016/bs.ircmb.2023.11.001 (Source: International Review of Cell and Molecular Biology)
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Jeannine Donahue Joshlyn Earls Valerie Fraser Ginny Mason Heather Pirowski Peggy Stephens Source Type: research

Advances in targets in inflammatory breast cancer
Int Rev Cell Mol Biol. 2024;384:125-152. doi: 10.1016/bs.ircmb.2023.10.005. Epub 2024 Feb 5.NO ABSTRACTPMID:38637096 | DOI:10.1016/bs.ircmb.2023.10.005 (Source: International Review of Cell and Molecular Biology)
Source: International Review of Cell and Molecular Biology - April 18, 2024 Category: Cytology Authors: Toshiaki Iwase Xiaoping Wang Lan Thi Hanh Phi Nithya Sridhar Naoto T Ueno Jangsoon Lee Source Type: research