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Survival outcomes seen with neoadjuvant chemotherapy in the management of locally advanced inflammatory breast cancer (IBC) versus matched controls
Breast. 2023 Oct 14;72:103591. doi: 10.1016/j.breast.2023.103591. Online ahead of print.ABSTRACTInflammatory breast cancer (IBC) poses an ongoing challenge as rates of disease recurrence and mortality remain high compared to stage-matched controls. However, frontline therapy has evolved through the years, including the widespread use of neoadjuvant chemotherapy (NAC) given the prognostic importance of pathologic complete response (pCR). Due to these sweeping changes, we need new data to assess current recurrence and survival outcomes for locally advanced IBC in the context of matched non-inflammatory controls. We conducted...
Source: Breast - October 23, 2023 Category: Cancer & Oncology Authors: Kai Cc Johnson Michael Grimm Jasmine Sukumar Patrick M Schnell Ko Un Park Daniel G Stover Sachin R Jhawar Margaret Gatti-Mays Robert Wesolowski Nicole Williams Sagar Sardesai Ashley Pariser Preeti Sudheendra Gary Tozbikian Bhuvaneswari Ramaswamy Dureti Do Source Type: research

Outcomes of Breast-Conserving Therapy in Patients With Inflammatory Breast Cancer: A Meta-Analysis
This study aimed to synthesize real-world data to evaluate the feasibility of breast-conserving therapy (BCT), sentinel lymph node (SLN), and sentinel lymph node biopsy (SLNB) for patients with IBC who respond to NAC. (Source: Journal of Surgical Research)
Source: Journal of Surgical Research - October 9, 2023 Category: Surgery Authors: Hui-Ying Lai, El-Wui Loh, Chih-Ming Su, Meng-Hsuan Chiang, Ka-Wai Tam Tags: Surgical Oncology Source Type: research

Cancers, Vol. 15, Pages 4883: Influence of Macrophages on Vascular Invasion of Inflammatory Breast Cancer Emboli Measured Using an In Vitro Microfluidic Multi-Cellular Platform
In this study, we present a 3D in vitro microfluidic IBC platform consisting of THP1 M0, M1, or M2 macrophages, IBC cells, and endothelial cells. The platform comprises a collagen matrix that includes an endothelialized vessel, creating a physiologically relevant environment for cellular interactions. Through the utilization of this platform, it was discovered that the inclusion of tumor-associated macrophages (TAMs) led to an increase in the formation of new blood vessel sprouts and enhanced permeability of the endothelium, regardless of the macrophage phenotype. Interestingly, the platforms containing THP-1 M1 or M2 macr...
Source: Cancers - October 8, 2023 Category: Cancer & Oncology Authors: Manasa Gadde Melika Mehrabi-Dehdezi Bisrat G. Debeb Wendy A. Woodward Marissa Nichole Rylander Tags: Article Source Type: research