Unmasking of systemic lupus erythematosus in a patient with hemophagocytic lymphohistiocytosis- macrophage activation syndrome (HLA-MAS) and diffuse alveolar hemorrhage
Reumatismo. 2023 Mar 21;74(4). doi: 10.4081/reumatismo.2022.1488.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by macrophages and cytotoxic T cells with aberrant activation. The primary (genetic) form, which is caused by mutations that affect lymphocyte cytotoxicity and immune regulation, is most prevalent in children, whereas the secondary (acquired) form is prevalent in adults. Secondary HLH is commonly caused by infections or cancers, but it can also be caused by autoimmune disorders, in which case it is known as macrophage activation syndrome (MAS; or MAS-HLH). A 25-year-old fe...
Source: Reumatismo - March 21, 2023 Category: Rheumatology Authors: P Sukhadiya P Kumar D S Meena A Kumar P H N Vijayan P Garg M K Garg Source Type: research
Unmasking of systemic lupus erythematosus in a patient with hemophagocytic lymphohistiocytosis- macrophage activation syndrome (HLA-MAS) and diffuse alveolar hemorrhage
Reumatismo. 2023 Mar 21;74(4). doi: 10.4081/reumatismo.2022.1488.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by macrophages and cytotoxic T cells with aberrant activation. The primary (genetic) form, which is caused by mutations that affect lymphocyte cytotoxicity and immune regulation, is most prevalent in children, whereas the secondary (acquired) form is prevalent in adults. Secondary HLH is commonly caused by infections or cancers, but it can also be caused by autoimmune disorders, in which case it is known as macrophage activation syndrome (MAS; or MAS-HLH). A 25-year-old fe...
Source: Reumatismo - March 21, 2023 Category: Rheumatology Authors: P Sukhadiya P Kumar D S Meena A Kumar P H N Vijayan P Garg M K Garg Source Type: research
Unmasking of systemic lupus erythematosus in a patient with hemophagocytic lymphohistiocytosis- macrophage activation syndrome (HLA-MAS) and diffuse alveolar hemorrhage
Reumatismo. 2023 Mar 21;74(4). doi: 10.4081/reumatismo.2022.1488.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a hyperinflammatory syndrome caused by macrophages and cytotoxic T cells with aberrant activation. The primary (genetic) form, which is caused by mutations that affect lymphocyte cytotoxicity and immune regulation, is most prevalent in children, whereas the secondary (acquired) form is prevalent in adults. Secondary HLH is commonly caused by infections or cancers, but it can also be caused by autoimmune disorders, in which case it is known as macrophage activation syndrome (MAS; or MAS-HLH). A 25-year-old fe...
Source: Reumatismo - March 21, 2023 Category: Rheumatology Authors: P Sukhadiya P Kumar D S Meena A Kumar P H N Vijayan P Garg M K Garg Source Type: research
Hypofibrinogenemic Massive Transfusion Trauma Patients Experience Worse Outcomes
CONCLUSION: Trauma patients undergoing MT with decreased admission fibrinogen demonstrate increased mortality. Other mortality risk factors include older age, decreased GCS, and higher ISS. Patients with increased fibrinogen levels had lower odds of mortality in a multivariable model. Post-MT survivors demonstrated significantly higher fibrinogen levels than pre-MT patients. Hypofibrinogenemic patients also had worse TEG parameters and required more PRBCs, FFP, and platelets during MT. Further studies are needed to assess the optimal volume of fibrinogen replacement with cryoprecipitate during MT to improve trauma patient ...
Source: The American Surgeon - March 13, 2023 Category: Surgery Authors: Mitchell J Parker Elizabeth W Crowder M Victoria P Miles Kevin N Harrell Robert A Maxwell Source Type: research
Hypofibrinogenemic Massive Transfusion Trauma Patients Experience Worse Outcomes
CONCLUSION: Trauma patients undergoing MT with decreased admission fibrinogen demonstrate increased mortality. Other mortality risk factors include older age, decreased GCS, and higher ISS. Patients with increased fibrinogen levels had lower odds of mortality in a multivariable model. Post-MT survivors demonstrated significantly higher fibrinogen levels than pre-MT patients. Hypofibrinogenemic patients also had worse TEG parameters and required more PRBCs, FFP, and platelets during MT. Further studies are needed to assess the optimal volume of fibrinogen replacement with cryoprecipitate during MT to improve trauma patient ...
Source: The American Surgeon - March 13, 2023 Category: Surgery Authors: Mitchell J Parker Elizabeth W Crowder M Victoria P Miles Kevin N Harrell Robert A Maxwell Source Type: research
Acquired hyperfibrinolysis as the presenting sign of metastatic breast cancer: A case report
In conclusion, the present case showed acquired hyperfibrinolysis with bleeding symptoms, which is an uncommon paraneoplastic phenomenon in breast cancer, especially when combined with bone marrow metastasis, as in the present case. Timely diagnosis and treatment of the primary disease is the fundamental way to improve hyperfibrinolysis. As an effective biomarker, fibrinogen level predicts the changes in a patient's illness and guides the clinical diagnosis and treatment process.PMID:36817045 | PMC:PMC9933151 | DOI:10.3892/ol.2023.13692 (Source: Oncology Letters)
Source: Oncology Letters - February 23, 2023 Category: Cancer & Oncology Authors: Guanyu Lu Lin Jia Ruohan Yang Zheng Lv Jiuwei Cui Source Type: research
Risk factors and clinical outcomes associated with acquired hypofibrinogenemia in patients administered hemocoagulase batroxobin for hemoptysis
CONCLUSIONS: The plasma fibrinogen levels in patients who were administered batroxobin for hemoptysis should be monitored, and batroxobin should be discontinued if hypofibrinogenemia occurs.PMID:36794140 | PMC:PMC9922611 | DOI:10.21037/jtd-22-717 (Source: Journal of Thoracic Disease)
Source: Journal of Thoracic Disease - February 16, 2023 Category: Respiratory Medicine Authors: Jae-Kyeong Lee Chang-Seok Yoon Young-Ok Na Hwa Kyung Park Hyung-Joo Oh Bo-Gun Kho Ha-Young Park Tae-Ok Kim Hong-Joon Shin Yong-Soo Kwon Yu-Il Kim Sung-Chul Lim Source Type: research
