Serum concentration as a predictor of tigecycline-induced hypofibrinogenemia in critically ill patients: a retrospective cohort study
The objective of this study was to determine the thresholds of serum concentration as a predictor of tigecycline-induced hypofibrinogenemia in critically ill patients. (Source: International Journal of Infectious Diseases)
Source: International Journal of Infectious Diseases - August 22, 2022 Category: Infectious Diseases Authors: Xiaoxuan Yang, Lu Jin, Xuemei Luo, Min Wang, Huaijun Zhu, Yujie Zhou, Weihong Ge Source Type: research
Uncommon defibrinogenation and coagulopathy caused by Trimeresurus stejnegeri stejnegeri envenomation in a patient with swelling above the ankle
Toxicon. 2022 Aug 17:S0041-0101(22)00245-8. doi: 10.1016/j.toxicon.2022.08.011. Online ahead of print.ABSTRACTIn Taiwan, Trimeresurus stejnegeri stejnegeri (Stejneger's Bamboo pitviper) is responsible for more than half of all venomous snakebites annually. This species often causes local envenoming characterized by tissue swelling and pain, occasional local ecchymosis, bullae and blister formation, and lymphangitis and lymphadenitis. The pathophysiology and treatment of potentially life-threatening coagulopathy and defibrinogenation induced by T. s. stejnegeri systemic envenoming have not been specifically addressed. Here,...
Source: Toxicon - August 20, 2022 Category: Toxicology Authors: Yu-Hsin Chen Yan-Chiao Mao Po-Yu Liu Liao-Chun Chiang Wei-Yu Chen Chih-Sheng Lai Cheng-Hsuan Ho Kuang-Ting Chen Wen-Loung Lin Cheng-Yang Wen Source Type: research
Uncommon defibrinogenation and coagulopathy caused by Trimeresurus stejnegeri stejnegeri envenomation in a patient with swelling above the ankle
Toxicon. 2022 Aug 17:S0041-0101(22)00245-8. doi: 10.1016/j.toxicon.2022.08.011. Online ahead of print.ABSTRACTIn Taiwan, Trimeresurus stejnegeri stejnegeri (Stejneger's Bamboo pitviper) is responsible for more than half of all venomous snakebites annually. This species often causes local envenoming characterized by tissue swelling and pain, occasional local ecchymosis, bullae and blister formation, and lymphangitis and lymphadenitis. The pathophysiology and treatment of potentially life-threatening coagulopathy and defibrinogenation induced by T. s. stejnegeri systemic envenoming have not been specifically addressed. Here,...
Source: Toxicon - August 20, 2022 Category: Toxicology Authors: Yu-Hsin Chen Yan-Chiao Mao Po-Yu Liu Liao-Chun Chiang Wei-Yu Chen Chih-Sheng Lai Cheng-Hsuan Ho Kuang-Ting Chen Wen-Loung Lin Cheng-Yang Wen Source Type: research
Overt Disseminated Intravascular Coagulation with Severe Hypofibrinogenemia During Veno-Venous Extracorporeal Membrane Oxygenation
We present an unusual case of a 74-year-old man who developed overt DIC during veno-venous (VV) ECMO. DIC resulted in clinical bleeding and severe hypofibrinogenemia requiring massive cryoprecipitate transfusion of 87 pooled units. When the patient was decannulated from ECMO, his platelet count and fibrinogen concentration improved within 24 hours, suggesting that ECMO was a proximate cause of his DIC.PMID:35928342 | PMC:PMC9302396 | DOI:10.1182/ject-148-152 (Source: Journal of Extra-Corporeal Technology)
Source: Journal of Extra-Corporeal Technology - August 5, 2022 Category: Cardiovascular & Thoracic Surgery Authors: Stephen Yang Brittney Williams David Kaczorowski Michael Mazzeffi Source Type: research
