Clinical characterization of hemophagocytic lymphohistiocytosis caused by immune checkpoint inhibitors: a review of published cases
CONCLUSION: HLH should be not underestimated as a potentially serious adverse effect of immune checkpoint inhibitors since appropriate treatments may save the life of patients.PMID:38606818 | DOI:10.1080/16078454.2024.2340144 (Source: Hematology)
Source: Hematology - April 12, 2024 Category: Hematology Authors: Zhiya Xu Huilan Li Xinyi Yu Jia Luo Zanling Zhang Source Type: research
Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies
Haematologica. 2024 Mar 28. doi: 10.3324/haematol.2023.284564. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular coagulation (DIC) and liver dysfunction. We investigated incidence and risk factors for hypofibrinogenemia in 41 consecutive adult patients with hematologic malignancies (median age 69 years, range 38-83 years) receiving CAR-T cell therapy between 01/2020 and 05/2023 at the University ...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Markus Perl Konstantin Herfeld Dennis C Harrer Matthias H öpting Marina Schweiger Ulrich Sterz Leonard Kn ödler Susanne Heimerl Leo Hansmann Wolfgang Herr Hendrik Poeck Daniel Wolff Matthias Edinger Christina Hart Matthias A Fante Source Type: research
Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies
Haematologica. 2024 Mar 28. doi: 10.3324/haematol.2023.284564. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular coagulation (DIC) and liver dysfunction. We investigated incidence and risk factors for hypofibrinogenemia in 41 consecutive adult patients with hematologic malignancies (median age 69 years, range 38-83 years) receiving CAR-T cell therapy between 01/2020 and 05/2023 at the University ...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Markus Perl Konstantin Herfeld Dennis C Harrer Matthias H öpting Marina Schweiger Ulrich Sterz Leonard Kn ödler Susanne Heimerl Leo Hansmann Wolfgang Herr Hendrik Poeck Daniel Wolff Matthias Edinger Christina Hart Matthias A Fante Source Type: research
Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies
Haematologica. 2024 Mar 28. doi: 10.3324/haematol.2023.284564. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular coagulation (DIC) and liver dysfunction. We investigated incidence and risk factors for hypofibrinogenemia in 41 consecutive adult patients with hematologic malignancies (median age 69 years, range 38-83 years) receiving CAR-T cell therapy between 01/2020 and 05/2023 at the University ...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Markus Perl Konstantin Herfeld Dennis C Harrer Matthias H öpting Marina Schweiger Ulrich Sterz Leonard Kn ödler Susanne Heimerl Leo Hansmann Wolfgang Herr Hendrik Poeck Daniel Wolff Matthias Edinger Christina Hart Matthias A Fante Source Type: research
Tocilizumab administration in cytokine release syndrome is associated with hypofibrinogenemia after chimeric antigen receptor T-cell therapy for hematologic malignancies
Haematologica. 2024 Mar 28. doi: 10.3324/haematol.2023.284564. Online ahead of print.ABSTRACTChimeric antigen receptor (CAR-) T cell therapy causes serious side effects including cytokine release syndrome (CRS). CRS-related coagulopathy is associated with hypofibrinogenemia that is thus far considered the result of disseminated intravascular coagulation (DIC) and liver dysfunction. We investigated incidence and risk factors for hypofibrinogenemia in 41 consecutive adult patients with hematologic malignancies (median age 69 years, range 38-83 years) receiving CAR-T cell therapy between 01/2020 and 05/2023 at the University ...
Source: Haematologica - March 28, 2024 Category: Hematology Authors: Markus Perl Konstantin Herfeld Dennis C Harrer Matthias H öpting Marina Schweiger Ulrich Sterz Leonard Kn ödler Susanne Heimerl Leo Hansmann Wolfgang Herr Hendrik Poeck Daniel Wolff Matthias Edinger Christina Hart Matthias A Fante Source Type: research
Data mining and safety analysis of traditional immunosuppressive drugs: a pharmacovigilance investigation based on the FAERS database
CONCLUSION: The AEs report on this study confirmed that the results were basically consistent with the previous studies, but there were also some important safety signals that were inconsistent with or not mentioned in previous published studies.EXPERT OPINION: The opinion section discusses some of the limitations and shortcomings, proposing the areas where more effort should be invested in order to improve the safety of immunosuppressive drugs.PMID:38533933 | DOI:10.1080/14740338.2024.2327503 (Source: Expert Opinion on Drug Safety)
Source: Expert Opinion on Drug Safety - March 27, 2024 Category: Drugs & Pharmacology Authors: Juan-Juan Li Li Chen Yang Zhao Xue-Qin Yang Fa-Bin Hu Li Wang Source Type: research
Management and outcomes of women with low fibrinogen concentration during pregnancy or immediately postpartum: A UK national population ‐based cohort study
ConclusionsFibrinogen<2 g/L often, but not exclusively, affected women with postpartum hemorrhage due to placental abruption, atony, or trauma. Other more rare and catastrophic obstetrical events such as amniotic fluid embolism and placenta accreta also led to low levels of fibrinogen. Maternal and perinatal mortality w as extremely high in our cohort. (Source: Acta Obstetricia et Gynecologica Scandinavica)
Source: Acta Obstetricia et Gynecologica Scandinavica - March 23, 2024 Category: OBGYN Authors: Caroline Diguisto,
Elfreda Baker,
Simon Stanworth,
Peter W. Collins,
Rachel E. Collis,
Marian Knight Tags: ORIGINAL RESEARCH ARTICLE Source Type: research
Probable secondary hemophagocytic lymphohistiocytosis manifesting as central nervous system lesions after COVID-19 vaccination: a case report
ConclusionTo date, 23 cases of COVID-19 vaccine-related HLH have been reported. Additionally, HLH in COVID-19 patients has been reported in various case reports. To the best of our knowledge, this is the first reported case of central nervous system involvement in HLH related to any type of COVID-19 vaccine. This case suggests that even when there are no systemic symptoms after COVID-19 vaccination, HLH should be considered as a differential diagnosis if brain lesions are suggestive of CNS demyelinating disease. (Source: Frontiers in Neurology)
Source: Frontiers in Neurology - March 11, 2024 Category: Neurology Source Type: research
Tigecycline-associated hypofibrinogenemia: A single center, retrospective, controlled study
The objective of our study was to assess changes in fibrinogen levels in patients for hospitalization, comparing two antibiotic episodes (tigecycline and other) within the same patients. (Source: Thrombosis Research)
Source: Thrombosis Research - March 4, 2024 Category: Hematology Authors: O ğuzhan Firat, Emre Kara, Ümit Yavuz Malkan, Kutay Demirkan, Ahmet Çağkan Inkaya Source Type: research
Effect of low fibrinogen level on in-hospital mortality and 6-month functional outcome of TBI patients, a single center experience
This study included all TBI patients admitted to our center who had no prior history of coagulopathy or any systemic disease, were alive on arrival, and had not received any blood product before admission. On admission, hospitalization, imaging, and 6-month follow-up information of included patients were extracted from the TBI registry database. The baseline characteristics of patients with fibrinogen levels of less than 150 mg/dL were compared with the cases with higher levels. To assess the effect of low fibrinogen levels on in-hospital mortality, a uni- and multivariate was conducted between those who died in hospital...
Source: Neurosurgical Review - February 28, 2024 Category: Neurosurgery Source Type: research
Erratum: Comparison of bleeding risk and hypofibrinogenemia-associated risk factors between tigecycline with cefoperazone/sulbactam therapy and other tigecycline-based combination therapies
(Source: Frontiers in Pharmacology)
Source: Frontiers in Pharmacology - January 15, 2024 Category: Drugs & Pharmacology Source Type: research
A single-center, retrospective analysis to compare measurement of fibrinogen using the TEG6 analyzer to the Clauss measurement in children undergoing heart surgery
CONCLUSION: This study demonstrates that whole blood functional fibrinogen, as estimated by TEG6s, tends to overestimate baseline plasma fibrinogen levels in pediatric age groups but aligns more accurately post-cardiopulmonary bypass, particularly in neonates and infants, suggesting its potential as a point-of-care tool in pediatric cardiac surgery. However, the variability in TEG6s performance before and after bypass highlights the need for careful interpretation of its results in clinical decision-making. Despite its contributions to understanding TEG6s in pediatric cardiac surgery, the study's design and inherent biases...
Source: Paediatric Anaesthesia - December 10, 2023 Category: Anesthesiology Authors: Nischal Gautam Vy Tran Evelyn Griffin Jehan Elliott Eric Rydalch Kelbie Kerr Alex J Wilkinson Xu Zhang Sepideh Saroukhani Source Type: research
Interest in the new thromboelastometry device, Clot Pro ®, for predicting thrombocytopenia and hypofibrinogenemia during lung transplantation
Lung transplantation is associated with high proportion of transfusion. Monitoring of coagulopathy using viscoelastic tests could aid in the perioperative management of bleeding. The aim of the study was to assess the predictive cut-off values for thrombocytopenia and hypofibrinogenemia using the new thromboelastography analyzer, ClotPro. (Source: Thrombosis Research)
Source: Thrombosis Research - November 28, 2023 Category: Hematology Authors: Tiffany Pascreau, Marine Gougeon, Julien Fessler, Sara Zia Chahabi, Morgan Le Guen, Marc Vasse Tags: Full Length Article Source Type: research
