Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: The American Journal of Tropical Medicine and Hygiene - July 10, 2023 Category: Tropical Medicine Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: The American Journal of Tropical Medicine and Hygiene - July 10, 2023 Category: Tropical Medicine Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: Am J Trop Med Hyg - July 10, 2023 Category: Infectious Diseases Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: Am J Trop Med Hyg - July 10, 2023 Category: Infectious Diseases Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: The American Journal of Tropical Medicine and Hygiene - July 10, 2023 Category: Tropical Medicine Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: Am J Trop Med Hyg - July 10, 2023 Category: Infectious Diseases Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: The American Journal of Tropical Medicine and Hygiene - July 10, 2023 Category: Tropical Medicine Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: Am J Trop Med Hyg - July 10, 2023 Category: Infectious Diseases Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: The American Journal of Tropical Medicine and Hygiene - July 10, 2023 Category: Tropical Medicine Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
Case Report: Diagnosis and Treatment of Two Clinical Cases of Visceral Leishmaniasis-Related Hemophagocytic Lymphohistiocytosis
We report two isolated cases of VL-HLH. The main clinical manifestations were fever, pancytopenia, splenomegaly, hypofibrinogenemia, and hyperferremia, which meet the HLH-2004 diagnostic criteria. In our experience, anti-HLH treatment was not very effective for either case. No Leishmania organism was found in the first bone marrow smear of either patient. The first patient was diagnosed after identification of Leishmania amastigotes via sternal bone marrow biopsy, rK39 immunochromatography test, and metagenomic next-generation sequencing. The other patient was diagnosed by rK39-rapid diagnostic test and polymerase chain re...
Source: Am J Trop Med Hyg - July 10, 2023 Category: Infectious Diseases Authors: Liuxue Wang Meng Hu Xusheng Wu Limin Ma Haiping Yang Source Type: research
First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene
Ann Clin Biochem. 2023 Jun 26:45632231186076. doi: 10.1177/00045632231186076. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by mutations in genes encoding proteins involved in the granule-dependent cytotoxic pathway (familial hemophagoc...
Source: Clinical Biochemistry - June 27, 2023 Category: Biochemistry Authors: Paula Sienes Bailo Nuria Go ñi Ros B árbara Menéndez Jándula Ramiro Álvarez Alegret Eduardo Gonz ález Gómez Ricardo Gonz ález Tarancón Silvia Izquierdo Álvarez Source Type: research
First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene
Ann Clin Biochem. 2023 Jun 26:45632231186076. doi: 10.1177/00045632231186076. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by mutations in genes encoding proteins involved in the granule-dependent cytotoxic pathway (familial hemophagoc...
Source: Clinical Biochemistry - June 27, 2023 Category: Biochemistry Authors: Paula Sienes Bailo Nuria Go ñi Ros B árbara Menéndez Jándula Ramiro Álvarez Alegret Eduardo Gonz ález Gómez Ricardo Gonz ález Tarancón Silvia Izquierdo Álvarez Source Type: research
First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene
Ann Clin Biochem. 2023 Jun 26:45632231186076. doi: 10.1177/00045632231186076. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by mutations in genes encoding proteins involved in the granule-dependent cytotoxic pathway (familial hemophagoc...
Source: Clinical Biochemistry - June 27, 2023 Category: Biochemistry Authors: Paula Sienes Bailo Nuria Go ñi Ros B árbara Menéndez Jándula Ramiro Álvarez Alegret Eduardo Gonz ález Gómez Ricardo Gonz ález Tarancón Silvia Izquierdo Álvarez Source Type: research
First case of very late-onset FHL2 in Spain with two variants in the PRF1 gene
Ann Clin Biochem. 2023 Jun 26:45632231186076. doi: 10.1177/00045632231186076. Online ahead of print.ABSTRACTHemophagocytic lymphohistiocytosis (HLH) is a rare but fatal disorder characterized by the proliferation and infiltration of macrophages and hyperactivated T lymphocytes that escape from the physiological control pathways and favour the existence of an environment of excessive inflammation and tissue destruction. HLH has been classified into two types: a primary or familial autosomal recessive form, caused by mutations in genes encoding proteins involved in the granule-dependent cytotoxic pathway (familial hemophagoc...
Source: Clinical Biochemistry - June 27, 2023 Category: Biochemistry Authors: Paula Sienes Bailo Nuria Go ñi Ros B árbara Menéndez Jándula Ramiro Álvarez Alegret Eduardo Gonz ález Gómez Ricardo Gonz ález Tarancón Silvia Izquierdo Álvarez Source Type: research
Comparison of bleeding risk and hypofibrinogenemia-associated risk factors between tigecycline with cefoperazone/sulbactam therapy and other tigecycline-based combination therapies
Conclusion: Tigecycline plus cefoperazone/sulbactam did not increase the risk of bleeding compared with tigecycline plus carbapenem, or tigecycline plus β-lactam antibiotics without NMTT-side-chains. Coagulation function should be closely monitored in patients receiving tigecycline treatment.PMID:37351509 | PMC:PMC10282135 | DOI:10.3389/fphar.2023.1182644 (Source: Cancer Control)
Source: Cancer Control - June 23, 2023 Category: Cancer & Oncology Authors: Lei Zhang Xinfeng Cai Fangchen Peng Shuangshuang Tian Xinjing Wu Yun Li Jinlin Guo Source Type: research
