Hypofibrinogenemic Massive Transfusion Trauma Patients Experience Worse Outcomes

CONCLUSION: Trauma patients undergoing MT with decreased admission fibrinogen demonstrate increased mortality. Other mortality risk factors include older age, decreased GCS, and higher ISS. Patients with increased fibrinogen levels had lower odds of mortality in a multivariable model. Post-MT survivors demonstrated significantly higher fibrinogen levels than pre-MT patients. Hypofibrinogenemic patients also had worse TEG parameters and required more PRBCs, FFP, and platelets during MT. Further studies are needed to assess the optimal volume of fibrinogen replacement with cryoprecipitate during MT to improve trauma patient mortality.PMID:36908225 | DOI:10.1177/00031348231162711

Source: The American Surgeon - March 13, 2023 Category: Surgery Authors: Mitchell J Parker Elizabeth W Crowder M Victoria P Miles Kevin N Harrell Robert A Maxwell Source Type: research