Oral administration of Manuka honey induces IFN γ-dependent resistance to tumor growth that correlates with beneficial modulation of gut microbiota composition
ConclusionOur findings highlight the immunostimulatory properties of MH and demonstrate its potential utilization in cancer prevention and treatment. (Source: Frontiers in Immunology)
Source: Frontiers in Immunology - February 20, 2024 Category: Allergy & Immunology Source Type: research
Synthesis, characterization, and application of honey stabilized inulin nanoparticles as colon targeting drug delivery carrier
This study presents a novel method for synthesizing highly stable and non-aggregatory inulin nanoparticles (INU NPs) by ionotropic gelation method, using calcium chloride as crosslinker and natural honey as a stabilizing agent. Different formulation and process parameters were optimized for the synthesis of monodispersed INU NPs. These INU NPs efficiently encapsulated a hydrophilic drug irinotecan hydrochloride trihydrate (IHT) and drug loaded formulation (IINPs) demonstrated excellent colloidal and storage stabilities. Notably, these IINPs exhibited pH-dependent drug release, suggesting potential for colon-specific drug d...
Source: International Journal of Biological Macromolecules - February 19, 2024 Category: Biochemistry Authors: Subin Joseph Mahima Jadav Raghu Solanki Sunita Patel Deep Pooja Hitesh Kulhari Source Type: research
Highly sensitive electrochemical sensing of norfloxacin by molecularly imprinted composite hollow spheres
Biosens Bioelectron. 2024 Feb 8;251:116119. doi: 10.1016/j.bios.2024.116119. Online ahead of print.ABSTRACTPoly (3,4-ethylenedioxythiophene) (PEDOT)-based molecularly imprinted electrochemical sensors have attracted widespread attention for monitoring contaminants in food and the environment. However, there are still problems such as poor hydrophilicity, easy agglomeration, and low selectivity in its preparation. In this work, a novel molecularly imprinted composite hollow sphere was prepared by a molecular imprinting technique using nitrogen-doped hollow carbon spheres as matrix material, and PEDOT and poly(methacrylic ac...
Source: Biosensors and Bioelectronics - February 11, 2024 Category: Biotechnology Authors: Yanqiang Zhou Abdukeyum Abdurexit Ruxangul Jamal Tursun Abdiryim Xiong Liu Fangfei Liu Feng Xu Yaolong Zhang Zhigang Wang Source Type: research
Aspartyl protease in the secretome of honey bee trypanosomatid parasite contributes to infection of bees
The exoproteome, which consists of both secreted proteins and those originating from cell surfaces and lysed cells, is a critical component of trypanosomatid parasites, facilitating interactions with host cell... (Source: Parasites and Vectors)
Source: Parasites and Vectors - February 10, 2024 Category: Microbiology Authors: Xuye Yuan, Jianying Sun and Tatsuhiko Kadowaki Tags: Research Source Type: research
Nematicidal activity of paucimannose-type glycoconjugates from acacia honey
Exp Parasitol. 2024 Feb 7;259:108707. doi: 10.1016/j.exppara.2024.108707. Online ahead of print.ABSTRACTNatural honey contains glycoconjugates as minor components. We characterized acacia honey glycoconjugates with molecular masses in the range of 2-5 kDa. The glycoconjugates were separated by RP-HPLC into three peaks (termed RP-2-5 k-I, RP-2-5 k-II, and RP-2-5 k-III) which demonstrated paralyzing effects on the model nematode C. elegans (ED50 of 50 ng glycoconjugates/μL). To examine molecular mechanisms underlying the nematicidal effects of honey glycoconjugates, expressional analyses of genes that are essential for the ...
Source: Experimental Parasitology - February 9, 2024 Category: Parasitology Authors: Bushra Bilal M Kamran Azim Source Type: research
Production, characterization and therapeutic efficacy of egg yolk antibodies specific to < i > Nosema ceranae < /i >
by Mehmet Nuri A çık, Burcu Karagülle, Seda Yakut, Yasin Öztürk, Mehmet Ali Kutlu, Recep Kalın, Burhan ÇetinkayaNosema disease, caused byNosema ceranae, one of the single-celled fungal microsporidian parasites, is one of the most important and common diseases of adult honey bees. Since fumagillin, which has been used for decades in the control ofNosema disease in honey bees (Apis mellifera), poses a toxic threat and its efficacy againstN.ceranae is uncertain, there is an urgent need to develop alternative prophylactic and curative strategies for the treatment of this disease. The main aim of this study was to invest...
Source: PLoS One - February 9, 2024 Category: Biomedical Science Authors: Mehmet Nuri A çık Source Type: research
Seasonal trends of the ABPV, KBV, and IAPV complex in Italian managed honey bee (Apis mellifera L.) colonies
This study improves our understanding of the circulation of bee viruses and will contribute to better disease prevention and preservation of bee health. (Source: Archives of Virology)
Source: Archives of Virology - February 9, 2024 Category: Virology Source Type: research
Characteristics and contributing factors of diagnostic error in surgery: analysis of closed medico-legal cases and complaints in Canada
CONCLUSION: In our cohort, diagnostic errors occurred in most surgical disciplines and across all surgical phases of care; contributing factors were commonly attributed to provider clinical decision-making and communication breakdown. Surgical patient safety efforts should include diagnostic errors with a focus on understanding and reducing errors in surgical clinical decision-making and improving communication.PMID:38320779 | PMC:PMC10852193 | DOI:10.1503/cjs.003523 (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - February 6, 2024 Category: Surgery Authors: Janice L Kwan Lisa A Calder Cara L Bowman Anna MacIntyre Richard Mimeault Liisa Honey Cynthia Dunn Gary Garber Hardeep Singh Source Type: research
Characteristics and contributing factors of diagnostic error in surgery: analysis of closed medico-legal cases and complaints in Canada
CONCLUSION: In our cohort, diagnostic errors occurred in most surgical disciplines and across all surgical phases of care; contributing factors were commonly attributed to provider clinical decision-making and communication breakdown. Surgical patient safety efforts should include diagnostic errors with a focus on understanding and reducing errors in surgical clinical decision-making and improving communication.PMID:38320779 | PMC:PMC10852193 | DOI:10.1503/cjs.003523 (Source: Canadian Journal of Surgery)
Source: Canadian Journal of Surgery - February 6, 2024 Category: Surgery Authors: Janice L Kwan Lisa A Calder Cara L Bowman Anna MacIntyre Richard Mimeault Liisa Honey Cynthia Dunn Gary Garber Hardeep Singh Source Type: research
